STRINGSTRING
CUL3 CUL3 INSR INSR PHIP PHIP LRP5 LRP5 ENSPPAP00000008479 ENSPPAP00000008479 DLGAP5 DLGAP5 SPHK1 SPHK1 CDC23 CDC23 NUP62 NUP62 PDGFB PDGFB CDC16 CDC16 IGF1 IGF1 ANAPC11 ANAPC11 RB1 RB1 ENSPPAP00000000734 ENSPPAP00000000734 EGF EGF ANAPC7 ANAPC7 NSMCE2 NSMCE2 MAD1L1 MAD1L1 TGFA TGFA HOXA13 HOXA13 EPGN EPGN MAD2L1BP MAD2L1BP PRAP1 PRAP1 ESPL1 ESPL1 EREG EREG EDN1 EDN1 AURKA AURKA IL1A IL1A ENSPPAP00000018466 ENSPPAP00000018466 BTC BTC ANAPC5 ANAPC5 RGCC RGCC CD28 CD28 ENSPPAP00000024117 ENSPPAP00000024117 NUSAP1 NUSAP1 IL1B IL1B FGF8 FGF8 SMPD3 SMPD3 PDGFRB PDGFRB DMRT1 DMRT1 CDC27 CDC27 IGF2 IGF2 SH2B1 SH2B1 EDN3 EDN3 CDT1 CDT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CUL3Cullin 3; Belongs to the cullin family. (795 aa)
INSRTyrosine-protein kinase receptor. (1362 aa)
PHIPPleckstrin homology domain interacting protein. (1784 aa)
LRP5LDL receptor related protein 5. (1839 aa)
ENSPPAP00000008479Protein kinase domain-containing protein. (383 aa)
DLGAP5DLG associated protein 5. (849 aa)
SPHK1Sphingosine kinase 1. (470 aa)
CDC23Cell division cycle 23. (597 aa)
NUP62Nsp1_C domain-containing protein. (419 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CDC16Cell division cycle 16. (620 aa)
IGF1IlGF domain-containing protein. (196 aa)
ANAPC11Anaphase promoting complex subunit 11. (196 aa)
RB1RB transcriptional corepressor 1. (911 aa)
ENSPPAP00000000734Uncharacterized protein. (554 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
ANAPC7Anaphase promoting complex subunit 7. (599 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (247 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
TGFATransforming growth factor alpha. (181 aa)
HOXA13Homeobox domain-containing protein. (209 aa)
EPGNUncharacterized protein. (85 aa)
MAD2L1BPMAD2L1 binding protein. (306 aa)
PRAP1Uncharacterized protein. (151 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2117 aa)
EREGEpiregulin. (169 aa)
EDN1Endothelin 1. (212 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (403 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
ENSPPAP00000018466Uncharacterized protein. (355 aa)
BTCBetacellulin. (178 aa)
ANAPC5Anaphase promoting complex subunit 5. (756 aa)
RGCCRegulator of cell cycle. (137 aa)
CD28CD28 molecule. (220 aa)
ENSPPAP00000024117Uncharacterized protein. (94 aa)
NUSAP1Uncharacterized protein. (365 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (638 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (371 aa)
CDC27Cell division cycle 27. (830 aa)
IGF2Insulin like growth factor 2. (236 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
EDN3Endothelin 3. (238 aa)
CDT1Chromatin licensing and DNA replication factor 1. (470 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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