STRINGSTRING
AXIN2 AXIN2 RGCC RGCC ENSPPAP00000023138 ENSPPAP00000023138 TCF12 TCF12 ENSPPAP00000024044 ENSPPAP00000024044 SKI SKI SMAD1 SMAD1 SAV1 SAV1 MEN1 MEN1 TGFBR3 TGFBR3 BMPR1B BMPR1B FOXH1 FOXH1 RNF111 RNF111 ENSPPAP00000005386 ENSPPAP00000005386 FOS FOS IPO7 IPO7 MEF2A MEF2A ANKRD1 ANKRD1 SMAD2 SMAD2 LDLRAD4 LDLRAD4 GATA4 GATA4 USP15 USP15 PURB PURB ZC3H3 ZC3H3 CTNNB1 CTNNB1 ACVRL1 ACVRL1 PPM1A PPM1A SKOR1 SKOR1 TRIM33 TRIM33 TGFB1I1 TGFB1I1 YY1 YY1 ENSPPAP00000027667 ENSPPAP00000027667 ACVR1B ACVR1B ACVR1 ACVR1 SMAD5 SMAD5 CITED1 CITED1 DROSHA DROSHA ZMIZ1 ZMIZ1 MAGI2 MAGI2 BMP2 BMP2 SKIL SKIL PML PML CREB3L1 CREB3L1 SMAD9 SMAD9 PPARG PPARG DAB2 DAB2 STUB1 STUB1 SMAD4 SMAD4 SMAD6 SMAD6 ENSPPAP00000042767 ENSPPAP00000042767 PAX6 PAX6 TGFBR2 TGFBR2 HIPK2 HIPK2 CITED2 CITED2 SMURF2 SMURF2 PURA PURA COL1A2 COL1A2 ENSPPAP00000039076 ENSPPAP00000039076 DDX5 DDX5 ZBTB7A ZBTB7A FERMT2 FERMT2 SMAD3 SMAD3 INTS8 INTS8 TGFBRAP1 TGFBRAP1 RANBP3L RANBP3L SMURF1 SMURF1 COL3A1 COL3A1 SNW1 SNW1 SMAD7 SMAD7 MYOCD MYOCD PARP1 PARP1 RANBP3 RANBP3 PMEPA1 PMEPA1 USP9X USP9X BMPR1A BMPR1A AXIN1 AXIN1 COL5A2 COL5A2 TGFBR1 TGFBR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AXIN2Axin 2. (843 aa)
RGCCRegulator of cell cycle. (137 aa)
ENSPPAP00000023138Uncharacterized protein. (373 aa)
TCF12Transcription factor 12. (706 aa)
ENSPPAP00000024044PPM-type phosphatase domain-containing protein. (75 aa)
SKISKI proto-oncogene. (666 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
MEN1Menin 1. (615 aa)
TGFBR3Transforming growth factor beta receptor 3. (861 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FOXH1Fork-head domain-containing protein. (452 aa)
RNF111Ring finger protein 111. (993 aa)
ENSPPAP00000005386C2 domain-containing protein. (54 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IPO7Importin 7. (1038 aa)
MEF2AMyocyte enhancer factor 2A. (505 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (269 aa)
GATA4GATA binding protein 4. (396 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
PURBPurine rich element binding protein B. (308 aa)
ZC3H3Zinc finger CCCH-type containing 3. (1095 aa)
CTNNB1Catenin beta 1. (781 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
SKOR1c-SKI_SMAD_bind domain-containing protein. (686 aa)
TRIM33Tripartite motif containing 33. (1083 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
YY1Uncharacterized protein. (370 aa)
ENSPPAP00000027667Uncharacterized protein. (98 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
DROSHADrosha ribonuclease III. (1369 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1035 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1256 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
SKILSKI like proto-oncogene. (684 aa)
PMLUncharacterized protein. (836 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
DAB2DAB adaptor protein 2. (752 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
ENSPPAP00000042767SKIP_SNW domain-containing protein. (390 aa)
PAX6Uncharacterized protein. (467 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
HIPK2Protein kinase domain-containing protein. (954 aa)
CITED2Uncharacterized protein. (179 aa)
SMURF2E3 ubiquitin-protein ligase. (790 aa)
PURAPurine rich element binding protein A. (288 aa)
COL1A2Collagen type I alpha 2 chain. (1274 aa)
ENSPPAP00000039076Importin N-terminal domain-containing protein. (70 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
ZBTB7AUncharacterized protein. (509 aa)
FERMT2Fermitin family member 2. (695 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
INTS8Integrator complex subunit 8. (995 aa)
TGFBRAP1Transforming growth factor beta receptor associated protein 1. (860 aa)
RANBP3LRAN binding protein 3 like. (490 aa)
SMURF1E3 ubiquitin-protein ligase. (752 aa)
COL3A1Collagen type III alpha 1 chain. (1465 aa)
SNW1SNW domain containing 1. (571 aa)
SMAD7MH2 domain-containing protein. (211 aa)
MYOCDMyocardin. (986 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
RANBP3RAN binding protein 3. (567 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (286 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2576 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
AXIN1Axin 1. (862 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.