(36 nodes) Platelet-derived growth factor receptor signaling pathway network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRP1	Neuropilin; Belongs to the neuropilin family. (924 aa)
	CSRNP1	Cysteine and serine rich nuclear protein 1. (591 aa)
	PLEKHA1	Pleckstrin homology domain containing A1. (404 aa)
	PDGFA	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (562 aa)
	JAK2	Tyrosine-protein kinase. (1143 aa)
	CLASP2	Uncharacterized protein. (1497 aa)
	ENSPPAP00000006969	Uncharacterized protein. (584 aa)
	MYO1E	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1026 aa)
	ENSPPAP00000006997	A20-type domain-containing protein. (127 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	ZFAND5	Zinc finger AN1-type containing 5. (213 aa)
	ENSPPAP00000009275	Uncharacterized protein. (269 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1313 aa)
	TIPARP	TCDD inducible poly(ADP-ribose) polymerase. (657 aa)
	CSPG4	Chondroitin sulfate proteoglycan 4. (2327 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (814 aa)
	PDGFRL	Platelet derived growth factor receptor like. (448 aa)
	RGS14	Regulator of G protein signaling 14. (567 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (916 aa)
	PDGFD	Platelet derived growth factor D. (329 aa)
	ENSPPAP00000024034	Uncharacterized protein. (541 aa)
	LOX	Lysyl oxidase. (417 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	SGPL1	Sphingosine-1-phosphate lyase 1. (568 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	ENSPPAP00000029143	Uncharacterized protein. (511 aa)
	ARID5B	AT-rich interaction domain 5B. (1187 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	NR4A3	Nuclear receptor domain-containing protein. (359 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (638 aa)
	FER	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (798 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BCAR1	ENSPPAP00000026444	ENSPPAP00000019881	Tyrosine-protein kinase.	BCAR1 scaffold protein, Cas family member.	0.653
ABL1	ENSPPAP00000029143	ENSPPAP00000026444	ENSPPAP00000029143	Tyrosine-protein kinase.	Uncharacterized protein.	0.444
ABL1	PDGFRB	ENSPPAP00000026444	ENSPPAP00000029028	Tyrosine-protein kinase.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.404
ABL1	PTPN11	ENSPPAP00000026444	ENSPPAP00000025051	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.444
BCAR1	ABL1	ENSPPAP00000019881	ENSPPAP00000026444	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.653
BCAR1	ITGB3	ENSPPAP00000019881	ENSPPAP00000014470	BCAR1 scaffold protein, Cas family member.	Integrin beta; Belongs to the integrin beta chain family.	0.845
BCAR1	PDGFA	ENSPPAP00000019881	ENSPPAP00000002818	BCAR1 scaffold protein, Cas family member.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.446
BCAR1	PDGFB	ENSPPAP00000019881	ENSPPAP00000013252	BCAR1 scaffold protein, Cas family member.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.491
BCAR1	PDGFRB	ENSPPAP00000019881	ENSPPAP00000029028	BCAR1 scaffold protein, Cas family member.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.577
BCAR1	PTPN1	ENSPPAP00000019881	ENSPPAP00000008568	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein phosphatase non-receptor type.	0.857
CSPG4	PDGFRB	ENSPPAP00000012988	ENSPPAP00000029028	Chondroitin sulfate proteoglycan 4.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.507
ENSPPAP00000006969	JAK2	ENSPPAP00000006969	ENSPPAP00000004553	Uncharacterized protein.	Tyrosine-protein kinase.	0.812
ENSPPAP00000006969	PDGFRB	ENSPPAP00000006969	ENSPPAP00000029028	Uncharacterized protein.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.897
ENSPPAP00000009275	JAK2	ENSPPAP00000009275	ENSPPAP00000004553	Uncharacterized protein.	Tyrosine-protein kinase.	0.812
ENSPPAP00000009275	PDGFRB	ENSPPAP00000009275	ENSPPAP00000029028	Uncharacterized protein.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.897
ENSPPAP00000024034	JAK2	ENSPPAP00000024034	ENSPPAP00000004553	Uncharacterized protein.	Tyrosine-protein kinase.	0.812
ENSPPAP00000024034	PDGFRB	ENSPPAP00000024034	ENSPPAP00000029028	Uncharacterized protein.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.897
ENSPPAP00000029143	ABL1	ENSPPAP00000029143	ENSPPAP00000026444	Uncharacterized protein.	Tyrosine-protein kinase.	0.444
ENSPPAP00000029143	ITGB3	ENSPPAP00000029143	ENSPPAP00000014470	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.447
ENSPPAP00000029143	JAK2	ENSPPAP00000029143	ENSPPAP00000004553	Uncharacterized protein.	Tyrosine-protein kinase.	0.888