(77 nodes) Phosphatidylinositol-mediated signaling network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PEAR1	Platelet endothelial aggregation receptor 1. (1029 aa)
	ENSPPAP00000025373	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1940 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (883 aa)
	PLCD3	Phosphoinositide phospholipase C. (737 aa)
	EZR	Ezrin. (604 aa)
	CA8	Carbonic anhydrase 8; Belongs to the alpha-carbonic anhydrase family. (290 aa)
	SERPINA12	Serpin family A member 12; Belongs to the serpin family. (414 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
	LOC100995377	Uncharacterized protein. (557 aa)
	PLCD4	Phosphoinositide phospholipase C. (794 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
	ENSPPAP00000034485	Uncharacterized protein. (90 aa)
	AKT1	Non-specific serine/threonine protein kinase. (501 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	TPTE2	Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2. (512 aa)
	GPR143	G protein-coupled receptor 143. (404 aa)
	PRR5	Proline rich 5. (411 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
	PRR5L	Proline rich 5 like. (368 aa)
	PLCL1	Phosphoinositide phospholipase C. (1047 aa)
	PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1468 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	ENSPPAP00000042092	Uncharacterized protein. (283 aa)
	EXOC1	Exocyst complex component 1. (901 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1057 aa)
	NPR3	Natriuretic peptide receptor 3. (532 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1635 aa)
	NF1	Neurofibromin 1. (2839 aa)
	C1QBP	Complement C1q binding protein. (282 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
	EDN1	Endothelin 1. (212 aa)
	BTN2A2	Butyrophilin subfamily 2 member A2. (523 aa)
	KBTBD2	Kelch repeat and BTB domain containing 2. (623 aa)
	PTEN	Uncharacterized protein. (542 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
	INPP5F	Inositol polyphosphate-5-phosphatase F. (1133 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
	ENSPPAP00000010121	Uncharacterized protein. (188 aa)
	PIK3R2	Uncharacterized protein. (663 aa)
	XBP1	BZIP domain-containing protein. (380 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1389 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	GATA3	GATA binding protein 3. (444 aa)
	PLCD1	Phosphoinositide phospholipase C. (781 aa)
	ENSPPAP00000006994	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (136 aa)
	PTAFR	Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	IRS1	Insulin receptor substrate 1. (1242 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (481 aa)
	IGF1	IlGF domain-containing protein. (196 aa)
	PLCH1	Phosphoinositide phospholipase C. (1693 aa)
	PLCL2	Phosphoinositide phospholipase C. (1101 aa)
	NYAP1	Neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1. (841 aa)
	PLEKHA1	Pleckstrin homology domain containing A1. (404 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (471 aa)
	FGFR1	Fibroblast growth factor receptor. (812 aa)
	MYO16	Myosin XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1819 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
	CD160	Uncharacterized protein. (234 aa)
	PLCH2	Phosphoinositide phospholipase C. (1415 aa)
	PLCE1	Phosphoinositide phospholipase C. (2276 aa)
	PLCZ1	Phosphoinositide phospholipase C. (639 aa)
	LTK	Tyrosine-protein kinase receptor. (864 aa)
	PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1559 aa)
	MUC5AC	Uncharacterized protein. (3342 aa)
	NYAP2	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2. (719 aa)
	CD28	CD28 molecule. (220 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1344 aa)
	PI4KB	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (830 aa)
	PITPNM2	Phosphatidylinositol transfer protein membrane associated 2. (1362 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	CD28	ENSPPAP00000034920	ENSPPAP00000023667	Non-specific serine/threonine protein kinase.	CD28 molecule.	0.626
AKT1	CSF1R	ENSPPAP00000034920	ENSPPAP00000038014	Non-specific serine/threonine protein kinase.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.515
AKT1	EDN1	ENSPPAP00000034920	ENSPPAP00000013795	Non-specific serine/threonine protein kinase.	Endothelin 1.	0.544
AKT1	ENSPPAP00000034485	ENSPPAP00000034920	ENSPPAP00000034485	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.444
AKT1	ERBB2	ENSPPAP00000034920	ENSPPAP00000037400	Non-specific serine/threonine protein kinase.	Receptor protein-tyrosine kinase.	0.412
AKT1	ERBB3	ENSPPAP00000034920	ENSPPAP00000024596	Non-specific serine/threonine protein kinase.	Erb-b2 receptor tyrosine kinase 3.	0.654
AKT1	EZR	ENSPPAP00000034920	ENSPPAP00000027860	Non-specific serine/threonine protein kinase.	Ezrin.	0.504
AKT1	GATA3	ENSPPAP00000034920	ENSPPAP00000007588	Non-specific serine/threonine protein kinase.	GATA binding protein 3.	0.411
AKT1	IGF1	ENSPPAP00000034920	ENSPPAP00000003648	Non-specific serine/threonine protein kinase.	IlGF domain-containing protein.	0.767
AKT1	IRS1	ENSPPAP00000034920	ENSPPAP00000004215	Non-specific serine/threonine protein kinase.	Insulin receptor substrate 1.	0.808
AKT1	LOC100995377	ENSPPAP00000034920	ENSPPAP00000033339	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.763
AKT1	NF1	ENSPPAP00000034920	ENSPPAP00000014745	Non-specific serine/threonine protein kinase.	Neurofibromin 1.	0.554
AKT1	PIK3C3	ENSPPAP00000034920	ENSPPAP00000013884	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.578
AKT1	PIK3CA	ENSPPAP00000034920	ENSPPAP00000010140	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.993
AKT1	PIK3CB	ENSPPAP00000034920	ENSPPAP00000017401	Non-specific serine/threonine protein kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.981
AKT1	PIK3CD	ENSPPAP00000034920	ENSPPAP00000025044	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.745
AKT1	PIK3CG	ENSPPAP00000034920	ENSPPAP00000040779	Non-specific serine/threonine protein kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.984
AKT1	PIK3R1	ENSPPAP00000034920	ENSPPAP00000038775	Non-specific serine/threonine protein kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.988
AKT1	PIK3R2	ENSPPAP00000034920	ENSPPAP00000009952	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.969
AKT1	PIK3R5	ENSPPAP00000034920	ENSPPAP00000026081	Non-specific serine/threonine protein kinase.	Phosphoinositide-3-kinase regulatory subunit 5.	0.955