(37 nodes) Positive regulation of mRNA splicing, via spliceosome network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	THRAP3	Thyroid hormone receptor associated protein 3. (954 aa)
	CIRBP	Cold inducible RNA binding protein. (295 aa)
	ENSPPAP00000021588	RRM domain-containing protein. (258 aa)
	RBM3	RNA binding motif protein 3. (157 aa)
	TRA2A	Transformer 2 alpha homolog. (281 aa)
	TRA2B	Transformer 2 beta homolog. (288 aa)
	SNRNP70	Small nuclear ribonucleoprotein U1 subunit 70. (437 aa)
	NUP98	Nucleoporin 98. (1807 aa)
	CLNS1A	Chloride nucleotide-sensitive channel 1A. (237 aa)
	ENSPPAP00000026635	RRM domain-containing protein. (107 aa)
	LOC100981595	Uncharacterized protein. (400 aa)
	ENSPPAP00000028140	Uncharacterized protein; Belongs to the heat shock protein 70 family. (501 aa)
	CELF3	CUGBP Elav-like family member 3. (464 aa)
	WDR77	WD repeat domain 77. (352 aa)
	PRDX6	Thioredoxin domain-containing protein. (281 aa)
	LOC100989391	Thioredoxin domain-containing protein. (208 aa)
	SF3B4	Splicing factor 3b subunit 4. (424 aa)
	SNW1	SNW domain containing 1. (571 aa)
	HSPA8	Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
	ENSPPAP00000037569	Uncharacterized protein. (134 aa)
	ENSPPAP00000038773	RRM domain-containing protein. (327 aa)
	SLC39A5	Solute carrier family 39 member 5. (540 aa)
	HMX2	Uncharacterized protein. (146 aa)
	ENSPPAP00000042767	SKIP_SNW domain-containing protein. (390 aa)
	DAZAP1	DAZ associated protein 1. (397 aa)
	PRMT5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (620 aa)
	ENSPPAP00000016619	Uncharacterized protein; Belongs to the heat shock protein 70 family. (564 aa)
	ENSPPAP00000015754	RRM domain-containing protein. (84 aa)
	ENSPPAP00000015368	Uncharacterized protein; Belongs to the heat shock protein 70 family. (630 aa)
	PRPF19	Pre-mRNA processing factor 19. (509 aa)
	ENSPPAP00000013733	Uncharacterized protein. (399 aa)
	RBMX	RNA binding motif protein X-linked. (391 aa)
	ENSPPAP00000007658	Uncharacterized protein. (191 aa)
	NCBP1	Nuclear cap binding protein subunit 1. (790 aa)
	CELF4	CUGBP Elav-like family member 4. (443 aa)
	LOC100991504	Uncharacterized protein; Belongs to the heat shock protein 70 family. (581 aa)
	NCL	Nucleolin. (710 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CIRBP	ENSPPAP00000038773	ENSPPAP00000020839	ENSPPAP00000038773	Cold inducible RNA binding protein.	RRM domain-containing protein.	0.439
CIRBP	NCBP1	ENSPPAP00000020839	ENSPPAP00000007333	Cold inducible RNA binding protein.	Nuclear cap binding protein subunit 1.	0.458
CIRBP	RBMX	ENSPPAP00000020839	ENSPPAP00000010402	Cold inducible RNA binding protein.	RNA binding motif protein X-linked.	0.638
CIRBP	TRA2A	ENSPPAP00000020839	ENSPPAP00000022412	Cold inducible RNA binding protein.	Transformer 2 alpha homolog.	0.435
CIRBP	TRA2B	ENSPPAP00000020839	ENSPPAP00000022891	Cold inducible RNA binding protein.	Transformer 2 beta homolog.	0.433
CLNS1A	PRMT5	ENSPPAP00000025628	ENSPPAP00000017972	Chloride nucleotide-sensitive channel 1A.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.983
CLNS1A	WDR77	ENSPPAP00000025628	ENSPPAP00000031861	Chloride nucleotide-sensitive channel 1A.	WD repeat domain 77.	0.980
DAZAP1	TRA2A	ENSPPAP00000020020	ENSPPAP00000022412	DAZ associated protein 1.	Transformer 2 alpha homolog.	0.453
DAZAP1	TRA2B	ENSPPAP00000020020	ENSPPAP00000022891	DAZ associated protein 1.	Transformer 2 beta homolog.	0.426
ENSPPAP00000007658	PRMT5	ENSPPAP00000007658	ENSPPAP00000017972	Uncharacterized protein.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.983
ENSPPAP00000007658	WDR77	ENSPPAP00000007658	ENSPPAP00000031861	Uncharacterized protein.	WD repeat domain 77.	0.980
ENSPPAP00000013733	ENSPPAP00000042767	ENSPPAP00000013733	ENSPPAP00000042767	Uncharacterized protein.	SKIP_SNW domain-containing protein.	0.669
ENSPPAP00000013733	NCBP1	ENSPPAP00000013733	ENSPPAP00000007333	Uncharacterized protein.	Nuclear cap binding protein subunit 1.	0.758
ENSPPAP00000013733	PRPF19	ENSPPAP00000013733	ENSPPAP00000014271	Uncharacterized protein.	Pre-mRNA processing factor 19.	0.699
ENSPPAP00000013733	SNRNP70	ENSPPAP00000013733	ENSPPAP00000023838	Uncharacterized protein.	Small nuclear ribonucleoprotein U1 subunit 70.	0.776
ENSPPAP00000013733	SNW1	ENSPPAP00000013733	ENSPPAP00000036281	Uncharacterized protein.	SNW domain containing 1.	0.669
ENSPPAP00000015368	NCL	ENSPPAP00000015368	ENSPPAP00000002680	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Nucleolin.	0.472
ENSPPAP00000015368	PRPF19	ENSPPAP00000015368	ENSPPAP00000014271	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Pre-mRNA processing factor 19.	0.670
ENSPPAP00000015754	NCBP1	ENSPPAP00000015754	ENSPPAP00000007333	RRM domain-containing protein.	Nuclear cap binding protein subunit 1.	0.465
ENSPPAP00000015754	NCL	ENSPPAP00000015754	ENSPPAP00000002680	RRM domain-containing protein.	Nucleolin.	0.447