STRINGSTRING
GAS6 GAS6 EGFR EGFR CCNB1 CCNB1 EREG EREG ENSPPAP00000039065 ENSPPAP00000039065 CD248 CD248 FN1 FN1 CTC1 CTC1 WAPL WAPL XRCC4 XRCC4 NGFR NGFR CCNA2 CCNA2 FGF10 FGF10 PDGFC PDGFC CDC6 CDC6 ZMIZ1 ZMIZ1 CDKN1A CDKN1A PDGFRB PDGFRB CD74 CD74 CDK4 CDK4 PLA2G1B PLA2G1B ABL1 ABL1 CDK6 CDK6 SIRT6 SIRT6 AQP1 AQP1 PDGFD PDGFD LIG4 LIG4 ENSPPAP00000019077 ENSPPAP00000019077 MIF MIF FBLN1 FBLN1 NDUFS4 NDUFS4 TGFB1 TGFB1 DDR2 DDR2 WNT2 WNT2 ITGB3 ITGB3 DHX9 DHX9 FBRS FBRS PDGFB PDGFB PML PML S100A6 S100A6 HRAS HRAS WNT5A WNT5A RNASEH2B RNASEH2B MYC MYC WNT1 WNT1 E2F1 E2F1 ESR1 ESR1 FOSL2 FOSL2 SPHK1 SPHK1 FNDC3B FNDC3B IGF1 IGF1 LIF LIF PDGFA PDGFA BRK1 BRK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAS6Growth arrest specific 6. (679 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
EREGEpiregulin. (169 aa)
ENSPPAP00000039065Uncharacterized protein. (350 aa)
CD248CD248 molecule. (726 aa)
FN1Fibronectin 1. (2477 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
WAPLWAPL cohesin release factor. (1190 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
NGFRNerve growth factor receptor. (427 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1035 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CD74CD74 molecule. (296 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PLA2G1BPhospholipase A(2). (148 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
CDK6Protein kinase domain-containing protein. (84 aa)
SIRT6Sirtuin 6. (355 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
PDGFDPlatelet derived growth factor D. (329 aa)
LIG4DNA ligase. (911 aa)
ENSPPAP00000019077Uncharacterized protein. (54 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (720 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (175 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
DHX9DExH-box helicase 9. (1270 aa)
FBRSFibrosin. (840 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PMLUncharacterized protein. (836 aa)
S100A6Protein S100; Belongs to the S-100 family. (90 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
RNASEH2BRibonuclease H2 subunit B. (303 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
E2F1E2F transcription factor 1. (397 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (309 aa)
SPHK1Sphingosine kinase 1. (470 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
IGF1IlGF domain-containing protein. (196 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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