STRINGSTRING
FZD5 FZD5 ANKS1A ANKS1A CATSPER4 CATSPER4 HES1 HES1 RB1 RB1 BRCA2 BRCA2 ENSPPAP00000001137 ENSPPAP00000001137 AKR1B1 AKR1B1 APP APP CCL21 CCL21 TDRD6 TDRD6 PRKACA PRKACA CEBPA CEBPA TUSC2 TUSC2 CATSPER2 CATSPER2 MAEA MAEA FBXO5 FBXO5 FEV FEV SLC26A3 SLC26A3 ELSPBP1 ELSPBP1 ENSPPAP00000004989 ENSPPAP00000004989 RHEX RHEX CATSPERD CATSPERD TDRD10 TDRD10 GATA3 GATA3 ROPN1L ROPN1L GATA2 GATA2 HOXB13 HOXB13 SLC26A6 SLC26A6 BRD1 BRD1 CNTN2 CNTN2 TFCP2L1 TFCP2L1 SRRM4 SRRM4 BFSP1 BFSP1 PGR PGR CNTNAP2 CNTNAP2 SOX10 SOX10 GLDN GLDN BAP1 BAP1 HIF1A HIF1A SIX3 SIX3 GPAT4 GPAT4 TDRKH TDRKH PPARG PPARG NTN4 NTN4 ENSPPAP00000011900 ENSPPAP00000011900 SEMG2 SEMG2 ANGPTL8 ANGPTL8 PICK1 PICK1 KCNIP2 KCNIP2 GHRHR GHRHR B4GALT5 B4GALT5 PLA2G3 PLA2G3 KCNB1 KCNB1 EDN1 EDN1 PLD6 PLD6 G6PD G6PD FEM1B FEM1B FAM210B FAM210B ENSPPAP00000015634 ENSPPAP00000015634 REC8 REC8 AGRN AGRN TGFB1 TGFB1 NR4A2 NR4A2 BCL2 BCL2 YTHDF2 YTHDF2 LGI4 LGI4 TDRD15 TDRD15 CCL19 CCL19 ENSPPAP00000020108 ENSPPAP00000020108 C1QL1 C1QL1 SCARF1 SCARF1 MECP2 MECP2 RET RET IHH IHH DLD DLD PCSK4 PCSK4 TDRD5 TDRD5 ROPN1 ROPN1 ENSPPAP00000023190 ENSPPAP00000023190 ACTL6B ACTL6B ENSPPAP00000023714 ENSPPAP00000023714 ENSPPAP00000024161 ENSPPAP00000024161 ROPN1B ROPN1B CTNNB1 CTNNB1 NRCAM NRCAM IQCF1 IQCF1 LHX6 LHX6 CCR6 CCR6 C3 C3 B4GALT6 B4GALT6 ASCL1 ASCL1 RUNX2 RUNX2 EPAS1 EPAS1 CX3CL1 CX3CL1 PTH1R PTH1R GDF11 GDF11 TYMS TYMS WASHC5 WASHC5 ADGRB3 ADGRB3 IL21 IL21 EDNRA EDNRA FLVCR1 FLVCR1 CDC25B CDC25B AXL AXL TUT4 TUT4 EFCAB9 EFCAB9 PTK2B PTK2B PTBP3 PTBP3 BHLHA15 BHLHA15 RND1 RND1 TUT7 TUT7 CABYR CABYR BTK BTK RPS6KA2 RPS6KA2 WDR77 WDR77 MTCH1 MTCH1 LOC100990946 LOC100990946 SLC26A8 SLC26A8 SLC22A14 SLC22A14 CATSPERE CATSPERE PABPC1L PABPC1L DMC1 DMC1 SCLT1 SCLT1 RFX3 RFX3 NKX6-1 NKX6-1 MTHFSD MTHFSD VSX1 VSX1 FAM20C FAM20C BFSP2 BFSP2 CFTR CFTR REN REN CATSPER3 CATSPER3 EPHA8 EPHA8 TDRD7 TDRD7 ZBTB7A ZBTB7A FGG FGG L3MBTL3 L3MBTL3 DEFB1 DEFB1 TDRD1 TDRD1 FARP2 FARP2 PDE3A PDE3A TMEM79 TMEM79 KDM1A KDM1A MYOC MYOC EPO EPO ENSPPAP00000039636 ENSPPAP00000039636 SPTBN4 SPTBN4 EREG EREG IQCF5 IQCF5 KDR KDR ABHD2 ABHD2 IL15 IL15 BSPH1 BSPH1 ERCC2 ERCC2 CATSPERZ CATSPERZ HOXA5 HOXA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
ANKS1AAnkyrin repeat and sterile alpha motif domain containing 1A. (1130 aa)
CATSPER4Cation channel sperm associated 4. (538 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
RB1RB transcriptional corepressor 1. (911 aa)
BRCA2BRCA2 DNA repair associated. (3417 aa)
ENSPPAP00000001137Uncharacterized protein. (59 aa)
AKR1B1Aldo-keto reductase family 1 member B. (263 aa)
APPAmyloid beta precursor protein. (770 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
TDRD6Uncharacterized protein. (901 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
CEBPABZIP domain-containing protein. (141 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (110 aa)
CATSPER2Cation channel sperm associated 2. (537 aa)
MAEACTLH domain-containing protein. (354 aa)
FBXO5F-box protein 5. (447 aa)
FEVETS domain-containing protein. (153 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (735 aa)
ELSPBP1Epididymal sperm binding protein 1. (219 aa)
ENSPPAP00000004989Aldo_ket_red domain-containing protein. (269 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion. (172 aa)
CATSPERDCation channel sperm associated auxiliary subunit delta. (721 aa)
TDRD10Tudor domain containing 10. (365 aa)
GATA3GATA binding protein 3. (444 aa)
ROPN1LRhophilin associated tail protein 1 like. (230 aa)
GATA2GATA binding protein 2. (480 aa)
HOXB13Homeobox B13. (284 aa)
SLC26A6Solute carrier family 26 member 6. (761 aa)
BRD1Bromodomain containing 1. (1189 aa)
CNTN2Contactin 2. (1040 aa)
TFCP2L1Transcription factor CP2 like 1. (518 aa)
SRRM4Serine/arginine repetitive matrix 4. (569 aa)
BFSP1Beaded filament structural protein 1; Belongs to the intermediate filament family. (646 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (636 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
SOX10SRY-box transcription factor 10. (466 aa)
GLDNGliomedin. (505 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
SIX3Homeobox domain-containing protein. (264 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
TDRKHTudor and KH domain containing. (605 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
NTN4Netrin 4. (628 aa)
ENSPPAP00000011900HMG box domain-containing protein. (291 aa)
SEMG2Semenogelin 2. (581 aa)
ANGPTL8Angiopoietin like 8. (198 aa)
PICK1Protein interacting with PRKCA 1. (415 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (285 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (371 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
EDN1Endothelin 1. (212 aa)
PLD6Phospholipase D family member 6. (252 aa)
G6PDGlucose-6-phosphate dehydrogenase. (560 aa)
FEM1BFem-1 homolog B. (627 aa)
FAM210BDUF1279 domain-containing protein. (178 aa)
ENSPPAP00000015634Uncharacterized protein. (233 aa)
REC8REC8 meiotic recombination protein. (547 aa)
AGRNAgrin. (1816 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (595 aa)
LGI4Leucine rich repeat LGI family member 4. (537 aa)
TDRD15Tudor domain containing 15. (1934 aa)
CCL19C-C motif chemokine. (98 aa)
ENSPPAP00000020108PlsC domain-containing protein. (328 aa)
C1QL1Complement C1q like 1. (236 aa)
SCARF1Scavenger receptor class F member 1. (830 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (493 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (402 aa)
DLDDihydrolipoyl dehydrogenase. (538 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4. (718 aa)
TDRD5Tudor domain containing 5. (1035 aa)
ROPN1Rhophilin associated tail protein 1. (212 aa)
ENSPPAP00000023190Aldo_ket_red domain-containing protein. (294 aa)
ACTL6BActin like 6B; Belongs to the actin family. (426 aa)
ENSPPAP00000023714Uncharacterized protein. (82 aa)
ENSPPAP00000024161Aldo_ket_red domain-containing protein. (232 aa)
ROPN1BUncharacterized protein. (80 aa)
CTNNB1Catenin beta 1. (781 aa)
NRCAMNeuronal cell adhesion molecule. (1272 aa)
IQCF1IQ motif containing F1. (205 aa)
LHX6LIM homeobox 6. (397 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (374 aa)
C3Complement C3. (1614 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (382 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (636 aa)
GDF11Growth differentiation factor 11. (398 aa)
TYMSThymidylate synthetase. (313 aa)
WASHC5WASH complex subunit 5. (1159 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (569 aa)
CDC25BCell division cycle 25B. (575 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
TUT4Terminal uridylyl transferase 4. (1659 aa)
EFCAB9EF-hand calcium binding domain 9. (197 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PTBP3Polypyrimidine tract binding protein 3. (515 aa)
BHLHA15Basic helix-loop-helix family member a15. (171 aa)
RND1Rho family GTPase 1. (232 aa)
TUT7Terminal uridylyl transferase 7. (1540 aa)
CABYRCalcium binding tyrosine phosphorylation regulated. (493 aa)
BTKTyrosine-protein kinase. (693 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
WDR77WD repeat domain 77. (352 aa)
MTCH1Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (349 aa)
LOC100990946PA2c domain-containing protein. (147 aa)
SLC26A8Testis anion transporter 1. (969 aa)
SLC22A14Solute carrier family 22 member 14. (594 aa)
CATSPERECatsper channel auxiliary subunit epsilon. (951 aa)
PABPC1LPolyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (614 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
SCLT1Sodium channel and clathrin linker 1. (717 aa)
RFX3Regulatory factor X3. (765 aa)
NKX6-1Homeobox domain-containing protein. (310 aa)
MTHFSDMethenyltetrahydrofolate synthetase domain containing. (383 aa)
VSX1Visual system homeobox 1. (365 aa)
FAM20CFam20C domain-containing protein. (475 aa)
BFSP2Beaded filament structural protein 2; Belongs to the intermediate filament family. (415 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1480 aa)
RENRenin; Belongs to the peptidase A1 family. (406 aa)
CATSPER3Cation channel sperm associated 3. (398 aa)
EPHA8EPH receptor A8. (997 aa)
TDRD7Tudor domain containing 7. (1077 aa)
ZBTB7AUncharacterized protein. (509 aa)
FGGFibrinogen gamma chain. (461 aa)
L3MBTL3L3MBTL histone methyl-lysine binding protein 3. (780 aa)
DEFB1Defensin beta 1. (68 aa)
TDRD1Tudor domain containing 1. (1189 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1027 aa)
PDE3APhosphodiesterase. (1141 aa)
TMEM79Transmembrane protein 79. (394 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
MYOCMyocilin. (504 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
ENSPPAP00000039636DUF1279 domain-containing protein. (209 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2442 aa)
EREGEpiregulin. (169 aa)
IQCF5IQ motif containing F5. (148 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ABHD2Abhydrolase domain containing 2. (435 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
BSPH1Binder of sperm protein homolog 1. (132 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
CATSPERZCatsper channel auxiliary subunit zeta. (200 aa)
HOXA5Homeobox A5. (270 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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