STRINGSTRING
PACSIN1 PACSIN1 ENSPPAP00000000505 ENSPPAP00000000505 DNM2 DNM2 BTBD8 BTBD8 SH3GL3 SH3GL3 LOC100978544 LOC100978544 SH3GL2 SH3GL2 OPHN1 OPHN1 NLGN4X NLGN4X SNCA SNCA ENSPPAP00000006504 ENSPPAP00000006504 SYNJ1 SYNJ1 FCHO2 FCHO2 DNAJC6 DNAJC6 SH3GL1 SH3GL1 SYNJ2 SYNJ2 NLGN3 NLGN3 SYT1 SYT1 SCRIB SCRIB ENSPPAP00000012927 ENSPPAP00000012927 PIP5K1C PIP5K1C NLGN1 NLGN1 GAK GAK DNM3 DNM3 AP2B1 AP2B1 SYT5 SYT5 SNCG SNCG ITSN2 ITSN2 STON2 STON2 SYP SYP ARF6 ARF6 CANX CANX DNM1 DNM1 LRRC1 LRRC1 CDK5 CDK5 ENSPPAP00000024234 ENSPPAP00000024234 ENSPPAP00000024326 ENSPPAP00000024326 SYT2 SYT2 SNCB SNCB AP2M1 AP2M1 AP3S1 AP3S1 PICALM PICALM AP3B2 AP3B2 SYNPR SYNPR AP3D1 AP3D1 ACTG1 ACTG1 ACTB ACTB SNAP91 SNAP91 RAB27B RAB27B SYT8 SYT8 DENND1A DENND1A NLGN2 NLGN2 ITSN1 ITSN1 NOSTRIN NOSTRIN ENSPPAP00000036655 ENSPPAP00000036655 LOC100967380 LOC100967380 AP3M2 AP3M2 AMPH AMPH KIAA1109 KIAA1109 STX1A STX1A BIN1 BIN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PACSIN1Protein kinase C and casein kinase substrate in neurons 1. (444 aa)
ENSPPAP00000000505AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (785 aa)
BTBD8BTB domain containing 8. (1409 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (355 aa)
LOC100978544Uncharacterized protein. (893 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (337 aa)
OPHN1Oligophrenin 1. (802 aa)
NLGN4XNeuroligin 4 X-linked. (873 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
ENSPPAP00000006504Uncharacterized protein. (378 aa)
SYNJ1Synaptojanin 1. (1614 aa)
FCHO2FCH domain only 2. (780 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (962 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
SYNJ2Synaptojanin 2. (1498 aa)
NLGN3Neuroligin 3. (848 aa)
SYT1Synaptotagmin 1. (422 aa)
SCRIBScribble planar cell polarity protein. (1656 aa)
ENSPPAP00000012927Uncharacterized protein; Belongs to the actin family. (336 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (676 aa)
NLGN1Neuroligin 1. (823 aa)
GAKCyclin G associated kinase. (1311 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
AP2B1AP complex subunit beta. (951 aa)
SYT5Synaptotagmin 5. (408 aa)
SNCGGamma-synuclein; Belongs to the synuclein family. (170 aa)
ITSN2Intersectin 2. (1693 aa)
STON2Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (920 aa)
SYPSynaptophysin. (313 aa)
ARF6Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
CANXCalnexin. (592 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (827 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
ENSPPAP00000024234Uncharacterized protein. (152 aa)
ENSPPAP00000024326Uncharacterized protein. (370 aa)
SYT2Synaptotagmin 2. (419 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (134 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (459 aa)
AP3S1Adaptor related protein complex 3 subunit sigma 1. (193 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (673 aa)
AP3B2AP-3 complex subunit beta. (1055 aa)
SYNPRSynaptoporin. (285 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1207 aa)
ACTG1Actin gamma 1. (375 aa)
ACTBActin beta; Belongs to the actin family. (372 aa)
SNAP91Synaptosome associated protein 91. (907 aa)
RAB27BRAB27B, member RAS oncogene family. (218 aa)
SYT8Synaptotagmin 8. (387 aa)
DENND1ADENN domain containing 1A. (1003 aa)
NLGN2COesterase domain-containing protein. (833 aa)
ITSN1Intersectin 1. (1720 aa)
NOSTRINNitric oxide synthase trafficking. (526 aa)
ENSPPAP00000036655Uncharacterized protein. (389 aa)
LOC100967380BAR domain-containing protein. (385 aa)
AP3M2AP-3 complex subunit mu-2. (418 aa)
AMPHAmphiphysin. (695 aa)
KIAA1109KIAA1109. (5005 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
BIN1Bridging integrator 1. (585 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.