STRINGSTRING
EPHB3 EPHB3 SFRP1 SFRP1 ID2 ID2 DACT1 DACT1 FGFR2 FGFR2 ENSPPAP00000024018 ENSPPAP00000024018 ASS1 ASS1 SMAD2 SMAD2 KCNQ1 KCNQ1 CTNNB1 CTNNB1 FOXF1 FOXF1 CYP1A1 CYP1A1 SALL1 SALL1 NKX2-3 NKX2-3 STRA6 STRA6 ASCL1 ASCL1 TYMS TYMS GLI2 GLI2 EPB41L5 EPB41L5 AGR2 AGR2 CPS1 CPS1 TP63 TP63 ENSPPAP00000029448 ENSPPAP00000029448 DCHS1 DCHS1 SCT SCT NIPBL NIPBL RARB RARB ENSPPAP00000030737 ENSPPAP00000030737 COBL COBL NKX2-2 NKX2-2 PDGFC PDGFC FGF10 FGF10 FOXF2 FOXF2 NOTCH1 NOTCH1 NKX3-2 NKX3-2 VPS52 VPS52 CHD8 CHD8 SIX2 SIX2 SRC SRC MYOCD MYOCD ENSPPAP00000036285 ENSPPAP00000036285 YIPF6 YIPF6 PKDCC PKDCC LOC100981710 LOC100981710 CBFA2T2 CBFA2T2 SPDEF SPDEF IFT172 IFT172 YAP1 YAP1 GLI3 GLI3 ACVR2B ACVR2B GLI1 GLI1 RARRES2 RARRES2 TCF21 TCF21 HOXA13 HOXA13 SLC4A2 SLC4A2 TGFBR2 TGFBR2 ENSPPAP00000042325 ENSPPAP00000042325 HOXA5 HOXA5 EGFR EGFR FZD5 FZD5 SOX17 SOX17 HES1 HES1 GATA4 GATA4 RB1 RB1 FGF9 FGF9 CLDN18 CLDN18 ENSPPAP00000001242 ENSPPAP00000001242 CCDC103 CCDC103 HOXD13 HOXD13 WNT11 WNT11 PERCC1 PERCC1 MIXL1 MIXL1 GATA6 GATA6 CCKBR CCKBR CRKL CRKL TNF TNF IL6ST IL6ST EXT1 EXT1 SHOX2 SHOX2 DNAAF1 DNAAF1 ADA ADA PRDM1 PRDM1 MEGF8 MEGF8 WNT5A WNT5A SAV1 SAV1 PCSK5 PCSK5 CCDC39 CCDC39 CCDC40 CCDC40 EDNRB EDNRB NKX2-6 NKX2-6 PTK6 PTK6 SOX10 SOX10 ENSPPAP00000010419 ENSPPAP00000010419 HIF1A HIF1A BMP4 BMP4 LGR4 LGR4 TIGAR TIGAR BBS7 BBS7 C1GALT1 C1GALT1 CXCL8 CXCL8 CLMP CLMP ZIC3 ZIC3 LOC100982721 LOC100982721 KLF5 KLF5 ENSPPAP00000014358 ENSPPAP00000014358 TGFB2 TGFB2 TBX2 TBX2 OTC OTC TGFB1 TGFB1 COL3A1 COL3A1 TGFB3 TGFB3 HLX HLX BCL2 BCL2 AHI1 AHI1 SMO SMO OVOL2 OVOL2 NODAL NODAL PDX1 PDX1 CDX2 CDX2 PYY PYY KIT KIT HMGCS2 HMGCS2 GATA5 GATA5 SHH SHH ALDH1A2 ALDH1A2 SMAD3 SMAD3 RET RET IHH IHH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHB3EPH receptor B3. (1031 aa)
SFRP1NTR domain-containing protein. (178 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (750 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
ENSPPAP00000024018Uncharacterized protein. (1204 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
KCNQ1Ion_trans domain-containing protein; Belongs to the potassium channel family. (557 aa)
CTNNB1Catenin beta 1. (781 aa)
FOXF1Forkhead box F1. (321 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
SALL1Spalt like transcription factor 1. (1306 aa)
NKX2-3Homeobox domain-containing protein. (303 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
TYMSThymidylate synthetase. (313 aa)
GLI2GLI family zinc finger 2. (1587 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (189 aa)
CPS1Carbamoyl-phosphate synthase 1. (1510 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ENSPPAP00000029448Uncharacterized protein. (397 aa)
DCHS1Dachsous cadherin-related 1. (3175 aa)
SCTUncharacterized protein. (172 aa)
NIPBLNipped-B protein. (2804 aa)
RARBRetinoic acid receptor beta. (448 aa)
ENSPPAP00000030737Uncharacterized protein. (408 aa)
COBLCordon-bleu WH2 repeat protein. (1279 aa)
NKX2-2NK2 homeobox 2. (273 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FOXF2Uncharacterized protein. (255 aa)
NOTCH1Notch receptor 1. (2573 aa)
NKX3-2NK3 homeobox 2. (291 aa)
VPS52VPS52 subunit of GARP complex. (723 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2573 aa)
SIX2SIX homeobox 2. (291 aa)
SRCTyrosine-protein kinase. (458 aa)
MYOCDMyocardin. (986 aa)
ENSPPAP00000036285Uncharacterized protein. (393 aa)
YIPF6Protein YIPF. (236 aa)
PKDCCProtein kinase domain-containing protein. (475 aa)
LOC100981710Uncharacterized protein. (389 aa)
CBFA2T2CBFA2/RUNX1 partner transcriptional co-repressor 2. (614 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
IFT172Intraflagellar transport 172. (1767 aa)
YAP1Yes associated protein 1. (512 aa)
GLI3GLI family zinc finger 3. (1580 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
GLI1GLI family zinc finger 1. (1106 aa)
RARRES2Retinoic acid receptor responder 2. (163 aa)
TCF21Transcription factor 21. (179 aa)
HOXA13Homeobox domain-containing protein. (209 aa)
SLC4A2Anion exchange protein. (1239 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
ENSPPAP00000042325Uncharacterized protein. (404 aa)
HOXA5Homeobox A5. (270 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
SOX17SRY-box transcription factor 17. (428 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
GATA4GATA binding protein 4. (396 aa)
RB1RB transcriptional corepressor 1. (911 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
ENSPPAP00000001242BHLH domain-containing protein. (117 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
HOXD13Homeobox domain-containing protein. (230 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PERCC1Uncharacterized protein. (262 aa)
MIXL1Homeobox domain-containing protein. (192 aa)
GATA6Uncharacterized protein. (402 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (514 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IL6STInterleukin 6 signal transducer. (928 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SHOX2Short stature homeobox 2. (355 aa)
DNAAF1Dynein assembly factor 1, axonemal. (616 aa)
ADAAdenosine deaminase. (412 aa)
PRDM1PR/SET domain 1. (825 aa)
MEGF8Multiple EGF like domains 8. (2845 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1860 aa)
CCDC39Coiled-coil domain containing 39. (941 aa)
CCDC40Coiled-coil domain containing 40. (1142 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
NKX2-6NK2 homeobox 6. (302 aa)
PTK6Tyrosine-protein kinase. (451 aa)
SOX10SRY-box transcription factor 10. (466 aa)
ENSPPAP00000010419Uncharacterized protein. (355 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (935 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (371 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
CLMPCXADR like membrane protein. (375 aa)
ZIC3Zic family member 3. (466 aa)
LOC100982721Uncharacterized protein. (245 aa)
KLF5Uncharacterized protein. (366 aa)
ENSPPAP00000014358Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (339 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TBX2T-box transcription factor 2. (622 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
COL3A1Collagen type III alpha 1 chain. (1465 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
HLXH2.0 like homeobox. (493 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
AHI1Abelson helper integration site 1. (1240 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (771 aa)
OVOL2Ovo like zinc finger 2. (225 aa)
NODALNodal growth differentiation factor. (347 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (263 aa)
CDX2Caudal type homeobox 2. (313 aa)
PYYPeptide YY. (95 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
GATA5GATA binding protein 5. (396 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (402 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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