STRINGSTRING
EHMT2 EHMT2 PRRX1 PRRX1 LHX3 LHX3 DLX1 DLX1 LOC100993131 LOC100993131 ZNF521 ZNF521 GSX1 GSX1 SHH SHH DMRTA2 DMRTA2 IHH IHH ISL1 ISL1 ID2 ID2 HOXC10 HOXC10 PROX1 PROX1 CTNNB1 CTNNB1 TLX3 TLX3 HOXD10 HOXD10 ASCL1 ASCL1 GLI2 GLI2 GBX1 GBX1 DLL1 DLL1 FOXN4 FOXN4 NKX2-2 NKX2-2 FEZF2 FEZF2 NOTCH1 NOTCH1 DLX2 DLX2 ENSPPAP00000035344 ENSPPAP00000035344 RBPJ RBPJ GLI3 GLI3 PAX6 PAX6 ENSPPAP00000001242 ENSPPAP00000001242 NKX2-1 NKX2-1 FKBP8 FKBP8 FOXG1 FOXG1 NOTCH3 NOTCH3 FEV FEV MNX1 MNX1 OLIG3 OLIG3 EYA1 EYA1 MYT1L MYT1L ATOH1 ATOH1 TBR1 TBR1 WNT1 WNT1 ISL2 ISL2 BCL11B BCL11B GATA2 GATA2 DMRT3 DMRT3 SMAD4 SMAD4 DLL4 DLL4 DBX1 DBX1 BMP4 BMP4 SUFU SUFU NKX6-2 NKX6-2 NRG1 NRG1 GSX2 GSX2 JAG2 JAG2 TGFBR1 TGFBR1 CDC42 CDC42
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EHMT2Euchromatic histone lysine methyltransferase 2. (1278 aa)
PRRX1Paired related homeobox 1. (245 aa)
LHX3LIM homeobox 3. (406 aa)
DLX1Distal-less homeobox 1. (255 aa)
LOC100993131Cell division control protein 42 homolog. (191 aa)
ZNF521Zinc finger protein 521. (1259 aa)
GSX1GS homeobox 1. (265 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
DMRTA2DM domain-containing protein. (503 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (402 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
HOXC10Homeobox C10. (342 aa)
PROX1Prospero homeobox 1. (737 aa)
CTNNB1Catenin beta 1. (781 aa)
TLX3T cell leukemia homeobox 3. (287 aa)
HOXD10Homeobox D10. (410 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
GLI2GLI family zinc finger 2. (1587 aa)
GBX1Gastrulation brain homeobox 1. (366 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (624 aa)
FOXN4Forkhead box N4. (512 aa)
NKX2-2NK2 homeobox 2. (273 aa)
FEZF2FEZ family zinc finger 2. (443 aa)
NOTCH1Notch receptor 1. (2573 aa)
DLX2Distal-less homeobox 2. (401 aa)
ENSPPAP00000035344Uncharacterized protein. (89 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
GLI3GLI family zinc finger 3. (1580 aa)
PAX6Uncharacterized protein. (467 aa)
ENSPPAP00000001242BHLH domain-containing protein. (117 aa)
NKX2-1Uncharacterized protein. (126 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
FOXG1Uncharacterized protein. (151 aa)
NOTCH3Notch receptor 3. (1981 aa)
FEVETS domain-containing protein. (153 aa)
MNX1Homeobox domain-containing protein. (149 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
MYT1LMyelin transcription factor 1 like. (1184 aa)
ATOH1Atonal bHLH transcription factor 1. (356 aa)
TBR1Uncharacterized protein. (231 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ISL2ISL LIM homeobox 2. (319 aa)
BCL11BUncharacterized protein. (459 aa)
GATA2GATA binding protein 2. (480 aa)
DMRT3DMA domain-containing protein. (334 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
DBX1Developing brain homeobox 1. (339 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (512 aa)
NKX6-2Homeobox domain-containing protein. (230 aa)
NRG1Neuregulin 1. (645 aa)
GSX2GS homeobox 2. (301 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1099 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
CDC42Uncharacterized protein. (191 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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