STRINGSTRING
FGFR2 FGFR2 HOXA1 HOXA1 COL1A1 COL1A1 FGF9 FGF9 DEAF1 DEAF1 NOG NOG MTHFD1 MTHFD1 HOXB7 HOXB7 WNT11 WNT11 MMP16 MMP16 HAND2 HAND2 PBX1 PBX1 SCX SCX EXT1 EXT1 SLC2A10 SLC2A10 EYA1 EYA1 ENSPPAP00000005060 ENSPPAP00000005060 SHOX2 SHOX2 MKS1 MKS1 MEGF8 MEGF8 SETD2 SETD2 COL2A1 COL2A1 WNT5A WNT5A PCSK5 PCSK5 HOXB2 HOXB2 TAPT1 TAPT1 MBTD1 MBTD1 ENSPPAP00000009786 ENSPPAP00000009786 SP3 SP3 HOXB9 HOXB9 MYF5 MYF5 BMP4 BMP4 SULF2 SULF2 UCMA UCMA TULP3 TULP3 CHST11 CHST11 TBXT TBXT SIX4 SIX4 TGFBR1 TGFBR1 PRRX1 PRRX1 KIAA1217 KIAA1217 HOXD1 HOXD1 HOXD3 HOXD3 TGFB3 TGFB3 DLX1 DLX1 PAX5 PAX5 HOXB6 HOXB6 NODAL NODAL TBX1 TBX1 OSR2 OSR2 HOXA3 HOXA3 BMP7 BMP7 HOXB3 HOXB3 MED12 MED12 OSR1 OSR1 HOXC5 HOXC5 XYLT1 XYLT1 WNT9B WNT9B GNAS-2 GNAS-2 SHH SHH IRX5 IRX5 NDST1 NDST1 DLG1 DLG1 DMRT2 DMRT2 SMAD3 SMAD3 MTHFD1L MTHFD1L ALX1 ALX1 IHH IHH HOXA7 HOXA7 HOXB8 HOXB8 HOXD4 HOXD4 SMAD2 SMAD2 CTNNB1 CTNNB1 COL11A1 COL11A1 ZEB1 ZEB1 HOXA2 HOXA2 HOXC9 HOXC9 TBX15 TBX15 HOXD10 HOXD10 CDK20 CDK20 RUNX2 RUNX2 ENSPPAP00000026779 ENSPPAP00000026779 HOXC6 HOXC6 MMP14 MMP14 EDNRA EDNRA FLVCR1 FLVCR1 MDFI MDFI HOXA11 HOXA11 WDR60 WDR60 PCGF2 PCGF2 NIPBL NIPBL HOXC4 HOXC4 HOXB1 HOXB1 HOXB5 HOXB5 HOXD9 HOXD9 NKX3-2 NKX3-2 DLX2 DLX2 SIX1 SIX1 DSCAML1 DSCAML1 HOXA6 HOXA6 FGF8 FGF8 SIX2 SIX2 WNT9A WNT9A HOXB4 HOXB4 GSC GSC LHX1 LHX1 IFT140 IFT140 RDH10 RDH10 SULF1 SULF1 FUZ FUZ ALX3 ALX3 SLC39A1 SLC39A1 GRHL2 GRHL2 WDR19 WDR19 GLI3 GLI3 HOXC11 HOXC11 TFAP2A TFAP2A TGFBR2 TGFBR2 HOXA4 HOXA4 ACVR2A ACVR2A SATB2 SATB2 HOXA5 HOXA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGFR2Fibroblast growth factor receptor. (822 aa)
HOXA1Homeobox A1. (336 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DEAF1Uncharacterized protein. (491 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
HOXB7Homeobox B7. (217 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MMP16Matrix metallopeptidase 16. (609 aa)
HAND2Uncharacterized protein. (66 aa)
PBX1PBX homeobox 1. (462 aa)
SCXBHLH domain-containing protein. (111 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
ENSPPAP00000005060Uncharacterized protein; Belongs to the DEAD box helicase family. (371 aa)
SHOX2Short stature homeobox 2. (355 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
MEGF8Multiple EGF like domains 8. (2845 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2536 aa)
COL2A1Uncharacterized protein. (1313 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1860 aa)
HOXB2Homeobox B2. (356 aa)
TAPT1Transmembrane anterior posterior transformation 1. (456 aa)
MBTD1Mbt domain containing 1. (630 aa)
ENSPPAP00000009786Homeobox domain-containing protein. (168 aa)
SP3Sp3 transcription factor. (721 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (138 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (501 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
TBXTT-box transcription factor T. (435 aa)
SIX4SIX homeobox 4. (775 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
PRRX1Paired related homeobox 1. (245 aa)
KIAA1217KIAA1217. (1943 aa)
HOXD1Homeobox domain-containing protein. (295 aa)
HOXD3Homeobox D3. (432 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
DLX1Distal-less homeobox 1. (255 aa)
PAX5Paired box 5. (337 aa)
HOXB6Homeobox B6. (224 aa)
NODALNodal growth differentiation factor. (347 aa)
TBX1Uncharacterized protein. (447 aa)
OSR2Odd-skipped related transciption factor 2. (433 aa)
HOXA3Homeobox A3. (443 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
HOXB3Homeobox B3. (413 aa)
MED12Mediator complex subunit 12. (2182 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
HOXC5Homeobox C5. (222 aa)
XYLT1Xylosyltransferase 1. (838 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa)
GNAS-2Uncharacterized protein. (245 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
IRX5Iroquois homeobox 5. (483 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
DMRT2Doublesex and mab-3 related transcription factor 2. (525 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (948 aa)
ALX1ALX homeobox 1. (326 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (402 aa)
HOXA7Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (230 aa)
HOXB8Homeobox B8. (243 aa)
HOXD4Homeobox protein Hox-D4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily. (255 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CTNNB1Catenin beta 1. (781 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
HOXA2Homeobox A2. (322 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
TBX15T-box transcription factor 15. (559 aa)
HOXD10Homeobox D10. (410 aa)
CDK20Cyclin dependent kinase 20; Belongs to the protein kinase superfamily. (376 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
ENSPPAP00000026779Uncharacterized protein. (720 aa)
HOXC6Homeobox C6. (235 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (569 aa)
MDFIMyoD family inhibitor. (246 aa)
HOXA11Homeobox A11. (327 aa)
WDR60WD repeat domain 60. (1061 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
NIPBLNipped-B protein. (2804 aa)
HOXC4Homeobox C4. (264 aa)
HOXB1Homeobox protein Hox-B1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (By similarity); Belongs to the Antp homeobox family. Labial subfamily. (301 aa)
HOXB5Homeobox B5. (269 aa)
HOXD9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (324 aa)
NKX3-2NK3 homeobox 2. (291 aa)
DLX2Distal-less homeobox 2. (401 aa)
SIX1SIX homeobox 1. (284 aa)
DSCAML1DS cell adhesion molecule like 1. (1975 aa)
HOXA6Homeobox A6. (233 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
SIX2SIX homeobox 2. (291 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
HOXB4Homeobox B4. (251 aa)
GSCHomeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity); Belongs to the paired homeobox family. Bicoid subfamily. (257 aa)
LHX1LIM homeobox 1. (406 aa)
IFT140Intraflagellar transport 140. (1457 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
ALX3ALX homeobox 3. (295 aa)
SLC39A1Solute carrier family 39 member 1. (324 aa)
GRHL2Grainyhead like transcription factor 2. (618 aa)
WDR19WD repeat domain 19. (1341 aa)
GLI3GLI family zinc finger 3. (1580 aa)
HOXC11Homeobox C11. (304 aa)
TFAP2ATF_AP-2 domain-containing protein. (328 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
HOXA4Homeobox domain-containing protein. (160 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
SATB2DNA-binding protein SATB. (733 aa)
HOXA5Homeobox A5. (270 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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