STRINGSTRING
SELENOK SELENOK HES1 HES1 DNAJA3 DNAJA3 TIRAP TIRAP ZAP70 ZAP70 IL7 IL7 CCR2 CCR2 VCAM1 VCAM1 MPL MPL TICAM1 TICAM1 IGF1 IGF1 JAK2 JAK2 IL6ST IL6ST PNP PNP IL23R IL23R ENSPPAP00000004806 ENSPPAP00000004806 TFRC TFRC ENSPPAP00000004994 ENSPPAP00000004994 DHPS DHPS CLECL1 CLECL1 VTCN1 VTCN1 TNFSF13B TNFSF13B ADA ADA VAV3 VAV3 IGFBP2 IGFBP2 HAVCR2 HAVCR2 TACR1 TACR1 CD276 CD276 IL18 IL18 FOXP3 FOXP3 CD24 CD24 AGER AGER FCRL3 FCRL3 TNFRSF4 TNFRSF4 PRKCQ PRKCQ NCK1 NCK1 BCL6 BCL6 IL12RB2 IL12RB2 RPS3 RPS3 SPTA1 SPTA1 CD70 CD70 ATAD5 ATAD5 IL2 IL2 ZP4 ZP4 ANXA1 ANXA1 CD81 CD81 PDCD1LG2 PDCD1LG2 SLAMF1 SLAMF1 TLR4 TLR4 KITLG KITLG ENSPPAP00000016729 ENSPPAP00000016729 CD320 CD320 CORO1A CORO1A CHRNB2 CHRNB2 CD3E CD3E CD1D CD1D HLA-DPA1 HLA-DPA1 BCL2 BCL2 MIF MIF TNFSF4 TNFSF4 IL1A IL1A CCDC88B CCDC88B GPR183 GPR183 EPHB2 EPHB2 CCL19 CCL19 TMIGD2 TMIGD2 SHH SHH WNT3A WNT3A HHLA2 HHLA2 ENSPPAP00000020965 ENSPPAP00000020965 CD86 CD86 PTPRC PTPRC CD274 CD274 FADD FADD BST1 BST1 CD28 CD28 CARD11 CARD11 CLCF1 CLCF1 IL12RB1 IL12RB1 IL6 IL6 LEP LEP IGF2 IGF2 PTPN22 PTPN22 CD38 CD38 SASH3 SASH3 TNFRSF13C TNFRSF13C ICOSLG ICOSLG IL2RA IL2RA SLC7A1 SLC7A1 IL12B IL12B IL27RA IL27RA CD74 CD74 MYD88 MYD88 IL21 IL21 CDKN1A CDKN1A SYK SYK CD6 CD6 NCK2 NCK2 HLA-E HLA-E GPAM GPAM IL12A IL12A BTK BTK NCKAP1L NCKAP1L TYK2 TYK2 AIF1 AIF1 FGF10 FGF10 CD80 CD80 MEF2C MEF2C ENSPPAP00000033446 ENSPPAP00000033446 CD40 CD40 STAT5B STAT5B IL1B IL1B TCF3 TCF3 LGALS9 LGALS9 EFNB1 EFNB1 NFATC2 NFATC2 JAK3 JAK3 ZP3 ZP3 HLA-DPB1 HLA-DPB1 RASAL3 RASAL3 ZNF335 ZNF335 SLC39A10 SLC39A10 CD40LG CD40LG PPP3CA PPP3CA TRAF6 TRAF6 IL23A IL23A PYCARD PYCARD TNFSF9 TNFSF9 IL15 IL15 IL5 IL5 TGFBR2 TGFBR2 CCL5 CCL5 RIPK2 RIPK2 PELI1 PELI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SELENOKSelenoprotein K. (89 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
TIRAPTIR domain-containing protein. (226 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
IL7Interleukin 7. (179 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
VCAM1Vascular cell adhesion molecule 1. (715 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (646 aa)
TICAM1RHIM domain-containing protein. (541 aa)
IGF1IlGF domain-containing protein. (196 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
IL6STInterleukin 6 signal transducer. (928 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
IL23RInterleukin 23 receptor. (629 aa)
ENSPPAP00000004806Uncharacterized protein. (142 aa)
TFRCTransferrin receptor. (773 aa)
ENSPPAP00000004994TNF receptor-associated factor. (475 aa)
DHPSUncharacterized protein. (369 aa)
CLECL1C-type lectin like 1. (192 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (285 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa)
ADAAdenosine deaminase. (412 aa)
VAV3Vav guanine nucleotide exchange factor 3. (917 aa)
IGFBP2Thyroglobulin type-1 domain-containing protein. (181 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (301 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CD276Ig-like domain-containing protein. (280 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
FOXP3Forkhead box P3. (441 aa)
CD24CD24 molecule. (129 aa)
AGERAdvanced glycosylation end-product specific receptor. (420 aa)
FCRL3Fc receptor like 3. (742 aa)
TNFRSF4TNF receptor superfamily member 4. (254 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (758 aa)
NCK1Cytoplasmic protein. (377 aa)
BCL6BCL6 transcription repressor. (706 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (740 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2338 aa)
CD70TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (193 aa)
ATAD5ATPase family AAA domain containing 5. (1832 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
ZP4Zona pellucida glycoprotein 4. (540 aa)
ANXA1Annexin. (346 aa)
CD81Tetraspanin. (270 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (273 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
ENSPPAP00000016729Ribosomal_S3_C domain-containing protein. (100 aa)
CD320CD320 molecule. (282 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
CD3ECD3e molecule. (207 aa)
CD1DCD1d molecule. (335 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
CCDC88BCoiled-coil domain containing 88B. (1347 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa)
EPHB2EPH receptor B2. (1039 aa)
CCL19C-C motif chemokine. (98 aa)
TMIGD2Transmembrane and immunoglobulin domain containing 2. (282 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
HHLA2HERV-H LTR-associating 2. (414 aa)
ENSPPAP00000020965KH type-2 domain-containing protein. (250 aa)
CD86CD86 molecule. (329 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1261 aa)
CD274CD274 molecule. (290 aa)
FADDDeath domain-containing protein. (144 aa)
BST1Bone marrow stromal cell antigen 1. (332 aa)
CD28CD28 molecule. (220 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
CLCF1Uncharacterized protein. (322 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (662 aa)
IL6Uncharacterized protein. (198 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
IGF2Insulin like growth factor 2. (236 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (807 aa)
CD38CD38 molecule. (300 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
TNFRSF13CUncharacterized protein. (112 aa)
ICOSLGUncharacterized protein. (463 aa)
IL2RASushi domain-containing protein. (249 aa)
SLC7A1Solute carrier family 7 member 1. (629 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
CD74CD74 molecule. (296 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
SYKTyrosine-protein kinase. (635 aa)
CD6CD6 molecule. (644 aa)
NCK2Cytoplasmic protein. (380 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (352 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
BTKTyrosine-protein kinase. (693 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CD80CD80 molecule. (288 aa)
MEF2CMyocyte enhancer factor 2C. (482 aa)
ENSPPAP00000033446KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (253 aa)
CD40CD40 molecule. (277 aa)
STAT5BSignal transducer and activator of transcription. (789 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
TCF3Transcription factor 3. (673 aa)
LGALS9Galectin. (355 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
JAK3Tyrosine-protein kinase. (1090 aa)
ZP3Zona pellucida glycoprotein 3. (373 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
RASAL3RAS protein activator like 3. (933 aa)
ZNF335Zinc finger protein 335. (1342 aa)
SLC39A10Solute carrier family 39 member 10. (831 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TNFSF9TNF superfamily member 9; Belongs to the tumor necrosis factor family. (253 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
CCL5C-C motif chemokine. (91 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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