STRINGSTRING
BMP7 BMP7 NRP1 NRP1 HES1 HES1 SEMA4D SEMA4D RB1 RB1 REST REST RTN4R RTN4R LINGO1 LINGO1 PITX3 PITX3 NOG NOG FSTL4 FSTL4 ENSPPAP00000002927 ENSPPAP00000002927 TSPO TSPO B2M B2M TRIM11 TRIM11 SLIT1 SLIT1 ATOH1 ATOH1 DAAM2 DAAM2 NFATC4 NFATC4 ABCC8 ABCC8 LDLR LDLR WNT5A WNT5A SORL1 SORL1 GDI1 GDI1 DIP2B DIP2B RYK RYK SEMA5B SEMA5B EFNB3 EFNB3 SOX10 SOX10 TP53 TP53 KIFAP3 KIFAP3 TRIM46 TRIM46 SEMA3E SEMA3E VAX1 VAX1 PTEN PTEN NKX6-2 NKX6-2 EPHA7 EPHA7 KIAA0319 KIAA0319 WNT7A WNT7A THY1 THY1 NTN1 NTN1 RAPGEF2 RAPGEF2 NF1 NF1 SEMA6D SEMA6D SKI SKI PTPRS PTPRS ENSPPAP00000015555 ENSPPAP00000015555 NF2 NF2 ENSPPAP00000016019 ENSPPAP00000016019 MAG MAG TGFB1 TGFB1 SEMA6B SEMA6B DAB1 DAB1 DLX1 DLX1 SEMA6A SEMA6A ENSPPAP00000017896 ENSPPAP00000017896 BRINP1 BRINP1 EPHB2 EPHB2 TLX2 TLX2 PTN PTN SEMA3G SEMA3G WNT3A WNT3A BCL11A BCL11A PRTG PRTG ENSPPAP00000022320 ENSPPAP00000022320 LHX2 LHX2 RUFY3 RUFY3 TNR TNR MCF2 MCF2 TRPC5 TRPC5 CDK5 CDK5 CDKL3 CDKL3 DICER1 DICER1 SYT4 SYT4 PROX1 PROX1 YWHAH YWHAH DUSP10 DUSP10 CTNNB1 CTNNB1 DRAXIN DRAXIN IL6 IL6 FGF13 FGF13 RNF6 RNF6 SEMA3A SEMA3A SEMA7A SEMA7A SIRT2 SIRT2 SYNGAP1 SYNGAP1 SEMA4C SEMA4C DCC DCC ID1 ID1 ULK2 ULK2 CDKN2B CDKN2B GORASP1 GORASP1 GPR37L1 GPR37L1 PLXNA3 PLXNA3 TMEM98 TMEM98 WNT3 WNT3 SEMA3D SEMA3D LIN28A LIN28A CTNNA1 CTNNA1 SPART SPART SEMA6C SEMA6C IFRD2 IFRD2 SEMA4B SEMA4B PSEN1 PSEN1 DPYSL5 DPYSL5 ENSPPAP00000032061 ENSPPAP00000032061 MBD1 MBD1 NR2E1 NR2E1 HOOK3 HOOK3 RTN4 RTN4 RNF10 RNF10 SEMA4G SEMA4G PCM1 PCM1 LOC100995377 LOC100995377 NOTCH1 NOTCH1 DLX2 DLX2 ARHGAP4 ARHGAP4 KDM4A KDM4A CERS2 CERS2 BMPR1A BMPR1A NKX6-1 NKX6-1 SPP1 SPP1 IL1B IL1B DLL3 DLL3 MT3 MT3 TREM2 TREM2 F2 F2 SEMA3F SEMA3F APPL2 APPL2 CCL11 CCL11 MAP2 MAP2 DYNLT1 DYNLT1 PPP3CA PPP3CA SEMA3B SEMA3B NR1D1 NR1D1 IFRD1 IFRD1 ULK1 ULK1 SEMA3C SEMA3C CTDSP1 CTDSP1 ENSPPAP00000041444 ENSPPAP00000041444 LRP4 LRP4 SEMA5A SEMA5A PAX6 PAX6 SEMA4A SEMA4A SEMA4F SEMA4F
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP7Bone morphogenetic protein 7. (431 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
RB1RB transcriptional corepressor 1. (911 aa)
RESTRE1 silencing transcription factor. (1097 aa)
RTN4RReticulon 4 receptor. (580 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
PITX3Homeobox protein. (208 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FSTL4Follistatin like 4. (842 aa)
ENSPPAP00000002927CCHC-type domain-containing protein. (202 aa)
TSPOTranslocator protein. (169 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
TRIM11Tripartite motif containing 11. (468 aa)
SLIT1Slit guidance ligand 1. (1533 aa)
ATOH1Atonal bHLH transcription factor 1. (356 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1077 aa)
NFATC4Nuclear factor of activated T cells 4. (963 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
LDLRLow density lipoprotein receptor. (849 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
SORL1Sortilin related receptor 1. (2214 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (447 aa)
DIP2BDisco interacting protein 2 homolog B. (1578 aa)
RYKUncharacterized protein. (475 aa)
SEMA5BSemaphorin 5B. (1091 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
SOX10SRY-box transcription factor 10. (466 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
KIFAP3Kinesin associated protein 3. (792 aa)
TRIM46Tripartite motif containing 46. (759 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
VAX1Homeobox domain-containing protein. (186 aa)
PTENUncharacterized protein. (542 aa)
NKX6-2Homeobox domain-containing protein. (230 aa)
EPHA7EPH receptor A7. (974 aa)
KIAA0319KIAA0319. (1108 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
THY1Thy-1 cell surface antigen. (161 aa)
NTN1Netrin 1. (528 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1611 aa)
NF1Neurofibromin 1. (2839 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1086 aa)
SKISKI proto-oncogene. (666 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1873 aa)
ENSPPAP00000015555RUN domain-containing protein. (544 aa)
NF2Neurofibromin 2. (595 aa)
ENSPPAP00000016019Uncharacterized protein. (144 aa)
MAGMyelin associated glycoprotein. (626 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SEMA6BSema domain-containing protein; Belongs to the semaphorin family. (706 aa)
DAB1DAB adaptor protein 1. (588 aa)
DLX1Distal-less homeobox 1. (255 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1043 aa)
ENSPPAP00000017896Uncharacterized protein. (214 aa)
BRINP1BMP/retinoic acid inducible neural specific 1. (761 aa)
EPHB2EPH receptor B2. (1039 aa)
TLX2T cell leukemia homeobox 2. (275 aa)
PTNPleiotrophin. (172 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (782 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (820 aa)
PRTGProtogenin. (1118 aa)
ENSPPAP00000022320Uncharacterized protein. (203 aa)
LHX2LIM homeobox 2. (406 aa)
RUFY3RUN and FYVE domain containing 3. (638 aa)
TNRTenascin R. (1360 aa)
MCF2MCF.2 cell line derived transforming sequence. (1044 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (973 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
CDKL3Cyclin dependent kinase like 3. (592 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
SYT4Synaptotagmin 4. (425 aa)
PROX1Prospero homeobox 1. (737 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (243 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (478 aa)
CTNNB1Catenin beta 1. (781 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
IL6Uncharacterized protein. (198 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
RNF6Ring finger protein 6. (685 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (771 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (622 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1346 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (832 aa)
DCCDCC netrin 1 receptor. (1457 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1007 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
GORASP1Golgi reassembly stacking protein 1. (440 aa)
GPR37L1G protein-coupled receptor 37 like 1. (481 aa)
PLXNA3Plexin A3. (1871 aa)
TMEM98Transmembrane protein 98. (226 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
LIN28ALin-28 homolog A. (209 aa)
CTNNA1Catenin alpha 1. (906 aa)
SPARTSpartin. (665 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (900 aa)
IFRD2Interferon related developmental regulator 2. (510 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (836 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
DPYSL5Dihydropyrimidinase like 5. (565 aa)
ENSPPAP00000032061Uncharacterized protein. (136 aa)
MBD1Methyl-CpG binding domain protein 1. (655 aa)
NR2E1Uncharacterized protein. (385 aa)
HOOK3Hook microtubule tethering protein 3. (721 aa)
RTN4Reticulon. (604 aa)
RNF10Ring finger protein 10. (774 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (843 aa)
PCM1Pericentriolar material 1. (2025 aa)
LOC100995377Uncharacterized protein. (557 aa)
NOTCH1Notch receptor 1. (2573 aa)
DLX2Distal-less homeobox 2. (401 aa)
ARHGAP4Rho GTPase activating protein 4. (986 aa)
KDM4AUncharacterized protein. (1064 aa)
CERS2Ceramide synthase 2. (380 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NKX6-1Homeobox domain-containing protein. (310 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
DLL3Uncharacterized protein. (493 aa)
MT3Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (647 aa)
CCL11C-C motif chemokine. (97 aa)
MAP2Microtubule-associated protein. (1826 aa)
DYNLT1Uncharacterized protein. (121 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (788 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
IFRD1Interferon related developmental regulator 1. (452 aa)
ULK1Protein kinase domain-containing protein. (1408 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
CTDSP1CTD small phosphatase 1. (261 aa)
ENSPPAP00000041444Uncharacterized protein. (121 aa)
LRP4LDL receptor related protein 4. (1857 aa)
SEMA5ASemaphorin 5A. (1074 aa)
PAX6Uncharacterized protein. (467 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (761 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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