STRINGSTRING
ARG2 ARG2 STAT2 STAT2 HFE HFE KLRD1 KLRD1 CTLA4 CTLA4 IL4R IL4R PGLYRP3 PGLYRP3 RABGEF1 RABGEF1 TNFRSF14 TNFRSF14 ZC3H12A ZC3H12A RPS19 RPS19 ENSPPAP00000021390 ENSPPAP00000021390 VSIG4 VSIG4 TBX21 TBX21 C4BPB C4BPB CEACAM1 CEACAM1 NMI NMI PGLYRP2 PGLYRP2 NLRC3 NLRC3 TNFAIP3 TNFAIP3 PTPRC PTPRC FURIN FURIN SUSD4 SUSD4 SERPINB9 SERPINB9 ENSPPAP00000023007 ENSPPAP00000023007 CLEC4G CLEC4G DUSP10 DUSP10 FOXF1 FOXF1 NLRC5 NLRC5 ENSPPAP00000025160 ENSPPAP00000025160 FYN FYN ZBTB7B ZBTB7B RC3H2 RC3H2 WDR41 WDR41 HMOX1 HMOX1 TTLL12 TTLL12 MMP12 MMP12 ENSPPAP00000021246 ENSPPAP00000021246 ENSPPAP00000020867 ENSPPAP00000020867 FGL2 FGL2 LGALS3 LGALS3 GRN GRN YTHDF2 YTHDF2 LOC100992972 LOC100992972 CD160 CD160 TNFSF4 TNFSF4 ADAR ADAR HLX HLX PLCG1 PLCG1 THOC1 THOC1 DCST1 DCST1 MUL1 MUL1 COL3A1 COL3A1 TGFB1 TGFB1 ARG1 ARG1 ENSPPAP00000016807 ENSPPAP00000016807 LOC100986982 LOC100986982 SMAD7 SMAD7 HLA-G HLA-G SLAMF1 SLAMF1 DHX58 DHX58 CR1L CR1L IL10 IL10 CCR2 CCR2 PSMA1 PSMA1 CD84 CD84 IL20RB IL20RB IRAK3 IRAK3 MKRN2 MKRN2 NLRX1 NLRX1 ENSPPAP00000004517 ENSPPAP00000004517 GFER GFER LOXL3 LOXL3 IFNL1 IFNL1 KLRC1 KLRC1 TREX1 TREX1 SMCR8 SMCR8 CR2 CR2 HAVCR2 HAVCR2 NDFIP1 NDFIP1 NR1H2 NR1H2 TRAFD1 TRAFD1 FCRLB FCRLB A2M A2M IL4 IL4 PTPN6 PTPN6 ENSPPAP00000010058 ENSPPAP00000010058 ENSPPAP00000009956 ENSPPAP00000009956 LYAR LYAR FOXJ1 FOXJ1 MASP1 MASP1 CD59 CD59 TRIM27 TRIM27 SPI1 SPI1 SAMSN1 SAMSN1 IL12B IL12B CACTIN CACTIN FOXP3 FOXP3 BANF1 BANF1 SOCS5 SOCS5 USP15 USP15 ATG12 ATG12 CNOT7 CNOT7 IL27RA IL27RA IL13RA2 IL13RA2 SYK SYK HCK HCK LOC100984838 LOC100984838 HLA-E HLA-E ENSPPAP00000030502 ENSPPAP00000030502 SAMHD1 SAMHD1 ENSPPAP00000031085 ENSPPAP00000031085 NCKAP1L NCKAP1L PTPN2 PTPN2 YES1 YES1 PGLYRP1 PGLYRP1 NR1H3 NR1H3 LOC100968163 LOC100968163 TNFSF18 TNFSF18 SPINK5 SPINK5 TREM2 TREM2 CR1 CR1 JAK3 JAK3 ENSPPAP00000036339 ENSPPAP00000036339 PARP3 PARP3 SRC SRC LILRB4 LILRB4 CD300A CD300A KIR3DL3 KIR3DL3 ATG5 ATG5 LGALS9 LGALS9 ENSPPAP00000035206 ENSPPAP00000035206 CSMD3 CSMD3 PLK2 PLK2 C4BPA C4BPA IL4I1 IL4I1 PARP14 PARP14 LOC100972110 LOC100972110 IL7R IL7R FER FER SERPING1 SERPING1 RHBDF2 RHBDF2 ARRB2 ARRB2 RC3H1 RC3H1 CD96 CD96 METTL3 METTL3 ENPP3 ENPP3 AMBP AMBP ENSPPAP00000001113 ENSPPAP00000001113 HLA-F HLA-F C9orf72 C9orf72 FAM3A FAM3A BCR BCR BCL6 BCL6 PPARG PPARG ENSPPAP00000011749 ENSPPAP00000011749 IL33 IL33 FGR FGR PSMB4 PSMB4 GPR17 GPR17 ALOX15 ALOX15 ACOD1 ACOD1 STAT6 STAT6 OAS1 OAS1 IFI16 IFI16 DRD2 DRD2 CRK CRK NLRP6 NLRP6 CLEC12B CLEC12B IL2 IL2 ISG15 ISG15 LYN LYN ANXA1 ANXA1 OTOP1 OTOP1 DNAJA3 DNAJA3 PPP3CB PPP3CB SELENOS SELENOS INPP5D INPP5D DUSP22 DUSP22 YTHDF3 YTHDF3 ENSPPAP00000041508 ENSPPAP00000041508 TRIM21 TRIM21 KIR2DS5 KIR2DS5 NOD2 NOD2 OAS3 OAS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARG2Arginase. (354 aa)
STAT2Signal transducer and activator of transcription. (853 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
KLRD1Killer cell lectin like receptor D1. (179 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
IL4RInterleukin 4 receptor. (873 aa)
PGLYRP3Peptidoglycan recognition protein 3. (341 aa)
RABGEF1RAB guanine nucleotide exchange factor 1. (505 aa)
TNFRSF14TNF receptor superfamily member 14. (283 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
RPS19Ribosomal protein S19. (145 aa)
ENSPPAP00000021390IGc1 domain-containing protein; Belongs to the MHC class I family. (351 aa)
VSIG4V-set and immunoglobulin domain containing 4. (399 aa)
TBX21T-box transcription factor 21. (494 aa)
C4BPBComplement component 4 binding protein beta. (252 aa)
CEACAM1Uncharacterized protein. (464 aa)
NMIN-myc and STAT interactor. (307 aa)
PGLYRP2Peptidoglycan recognition protein 2. (633 aa)
NLRC3NLR family CARD domain containing 3. (1112 aa)
TNFAIP3TNF alpha induced protein 3. (784 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1261 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
SUSD4Sushi domain containing 4. (489 aa)
SERPINB9Serpin family B member 9; Belongs to the serpin family. (376 aa)
ENSPPAP00000023007A20-type domain-containing protein. (104 aa)
CLEC4GC-type lectin domain family 4 member G. (272 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (478 aa)
FOXF1Forkhead box F1. (321 aa)
NLRC5NLR family CARD domain containing 5. (1865 aa)
ENSPPAP00000025160Tyrosine-protein kinase. (483 aa)
FYNTyrosine-protein kinase. (537 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
WDR41WD repeat domain 41. (495 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
TTLL12Tubulin tyrosine ligase like 12. (641 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
ENSPPAP00000021246SOCS box domain-containing protein. (478 aa)
ENSPPAP00000020867A20-type domain-containing protein. (111 aa)
FGL2Fibrinogen like 2. (439 aa)
LGALS3Galectin. (250 aa)
GRNGranulin precursor. (593 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (595 aa)
LOC100992972Uncharacterized protein. (1435 aa)
CD160Uncharacterized protein. (234 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
ADARA to I editase domain-containing protein. (193 aa)
HLXH2.0 like homeobox. (493 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1248 aa)
THOC1THO complex 1. (660 aa)
DCST1DC-STAMP domain containing 1. (706 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
COL3A1Collagen type III alpha 1 chain. (1465 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ARG1Arginase. (322 aa)
ENSPPAP00000016807Uncharacterized protein. (61 aa)
LOC100986982Uncharacterized protein. (368 aa)
SMAD7MH2 domain-containing protein. (211 aa)
HLA-GMajor histocompatibility complex, class I, G; Belongs to the MHC class I family. (355 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
DHX58DExH-box helicase 58. (678 aa)
CR1LComplement C3b/C4b receptor 1 like. (569 aa)
IL10Interleukin 10. (178 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
PSMA1Proteasome endopeptidase complex. (238 aa)
CD84CD84 molecule. (345 aa)
IL20RBInterleukin 20 receptor subunit beta. (281 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
MKRN2Makorin ring finger protein 2. (418 aa)
NLRX1NLR family member X1. (975 aa)
ENSPPAP00000004517Uncharacterized protein. (654 aa)
GFERSulfhydryl oxidase. (196 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
IFNL1Interferon lambda 1. (200 aa)
KLRC1Killer cell lectin like receptor C1. (233 aa)
TREX1Three prime repair exonuclease 1. (369 aa)
SMCR8SMCR8-C9orf72 complex subunit. (937 aa)
CR2Complement C3d receptor 2. (969 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (301 aa)
NDFIP1Nedd4 family interacting protein 1. (200 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
TRAFD1TRAF-type zinc finger domain containing 1. (582 aa)
FCRLBFc receptor like B. (419 aa)
A2MAlpha-2-macroglobulin. (1474 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
ENSPPAP00000010058Uncharacterized protein. (165 aa)
ENSPPAP00000009956Uncharacterized protein. (245 aa)
LYARLy1 antibody reactive. (379 aa)
FOXJ1Forkhead box J1. (405 aa)
MASP1Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (728 aa)
CD59UPAR/Ly6 domain-containing protein. (152 aa)
TRIM27Tripartite motif containing 27. (513 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
SAMSN1SAM domain, SH3 domain and nuclear localization signals 1. (441 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
CACTINCactin, spliceosome C complex subunit. (710 aa)
FOXP3Forkhead box P3. (441 aa)
BANF1Barrier to autointegration factor 1. (89 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (181 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (380 aa)
SYKTyrosine-protein kinase. (635 aa)
HCKTyrosine-protein kinase. (526 aa)
LOC100984838Uncharacterized protein. (334 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (352 aa)
ENSPPAP00000030502Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (849 aa)
SAMHD1SAM domain and HD domain-containing protein 1. (626 aa)
ENSPPAP00000031085Uncharacterized protein. (277 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (424 aa)
YES1Tyrosine-protein kinase. (548 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (196 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
LOC100968163Uncharacterized protein. (579 aa)
TNFSF18TNF superfamily member 18. (199 aa)
SPINK5Serine peptidase inhibitor, Kazal type 5. (1094 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
CR1Uncharacterized protein. (582 aa)
JAK3Tyrosine-protein kinase. (1090 aa)
ENSPPAP00000036339Uncharacterized protein. (244 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
SRCTyrosine-protein kinase. (458 aa)
LILRB4Leukocyte immunoglobulin like receptor B4. (408 aa)
CD300ACD300a molecule. (299 aa)
KIR3DL3Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3. (351 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
LGALS9Galectin. (355 aa)
ENSPPAP00000035206Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (156 aa)
CSMD3CUB and Sushi multiple domains 3. (3707 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
C4BPAComplement component 4 binding protein alpha. (597 aa)
IL4I1Amine oxidase. (589 aa)
PARP14Poly [ADP-ribose] polymerase. (1801 aa)
LOC100972110Uncharacterized protein. (542 aa)
IL7RInterleukin 7 receptor. (459 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (798 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (496 aa)
RHBDF2Rhomboid 5 homolog 2. (827 aa)
ARRB2Arrestin beta 2. (447 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
CD96CD96 molecule. (585 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (875 aa)
AMBPAlpha-1-microglobulin/bikunin precursor. (364 aa)
ENSPPAP00000001113Uncharacterized protein. (89 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (441 aa)
C9orf72C9orf72-SMCR8 complex subunit. (478 aa)
FAM3AFamily with sequence similarity 3 member A. (244 aa)
BCRUncharacterized protein. (1034 aa)
BCL6BCL6 transcription repressor. (706 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ENSPPAP00000011749Uncharacterized protein. (77 aa)
IL33Interleukin 33. (270 aa)
FGRTyrosine-protein kinase. (529 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
GPR17G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (367 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
ACOD1Aconitate decarboxylase 1. (490 aa)
STAT6Signal transducer and activator of transcription. (852 aa)
OAS12',5'-oligoadenylate synthetase 1. (401 aa)
IFI16Interferon gamma inducible protein 16. (733 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
CLEC12BC-type lectin domain family 12 member B. (276 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
ISG15ISG15 ubiquitin like modifier. (165 aa)
LYNTyrosine-protein kinase. (526 aa)
ANXA1Annexin. (346 aa)
OTOP1Otopetrin 1. (612 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
SELENOSUncharacterized protein. (218 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (587 aa)
ENSPPAP00000041508A20-type domain-containing protein. (110 aa)
TRIM21Tripartite motif containing 21. (475 aa)
KIR2DS5IG domain-containing protein. (200 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1082 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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