STRINGSTRING
HAVCR2 HAVCR2 C5AR1 C5AR1 SSC5D SSC5D LOC100991118 LOC100991118 LOC100991783 LOC100991783 ENSPPAP00000009556 ENSPPAP00000009556 IL18 IL18 GBP4 GBP4 NOD1 NOD1 ENSPPAP00000010678 ENSPPAP00000010678 IL17A IL17A REG3G REG3G IL6R IL6R DEFB118 DEFB118 FGR FGR DEFB119 DEFB119 RNASE9 RNASE9 NLRP6 NLRP6 DEFB114 DEFB114 ZG16 ZG16 CRP CRP ANG ANG ENSPPAP00000019306 ENSPPAP00000019306 RNASE12 RNASE12 RNASE4 RNASE4 TAC1 TAC1 LOC100993063 LOC100993063 RNASE7 RNASE7 RNASE6 RNASE6 LYG2 LYG2 PGLYRP2 PGLYRP2 RIPK2 RIPK2 PGLYRP3 PGLYRP3 RARRES2 RARRES2 TNFSF8 TNFSF8 PYCARD PYCARD STAB2 STAB2 PPP1R11 PPP1R11 NOD2 NOD2 RPL39 RPL39 C10orf99 C10orf99 CASP4 CASP4 CAMP CAMP DEFA6 DEFA6 DEFB1 DEFB1 TNFRSF14 TNFRSF14 MBL2 MBL2 DCD DCD FAU FAU CALCA CALCA IL1B IL1B HAMP HAMP IL7R IL7R IL17F IL17F GBP2 GBP2 LTA LTA PGLYRP1 PGLYRP1 LYZ LYZ GSDMD GSDMD IL12A IL12A HLA-E HLA-E ADAM17 ADAM17 CARD9 CARD9 DROSHA DROSHA MYD88 MYD88 IL27RA IL27RA PLA2G1B PLA2G1B LBP LBP IL6 IL6 DEFA4 DEFA4 PLA2G2A PLA2G2A ADM ADM CD36 CD36 ENSPPAP00000001140 ENSPPAP00000001140 TIRAP TIRAP SEH1L SEH1L RNASE1 RNASE1 EPHA2 EPHA2 NLRP3 NLRP3 CTSG CTSG LCE3C LCE3C CHGA CHGA H2BC10 H2BC10 TBK1 TBK1 TNF TNF P2RX7 P2RX7 RNASE11 RNASE11 MR1 MR1 LTF LTF LOC100985450 LOC100985450 GBP6 GBP6 ENSPPAP00000022875 ENSPPAP00000022875 LYG1 LYG1 ENSPPAP00000024365 ENSPPAP00000024365 LOC100979846 LOC100979846 RNASE8 RNASE8 ACP5 ACP5 MPEG1 MPEG1 LCE3B LCE3B H2BC11 H2BC11 LOC100981154 LOC100981154 PGLYRP4 PGLYRP4 LOC100985433 LOC100985433 ROMO1 ROMO1 H2BC6 H2BC6 TLR2 TLR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HAVCR2Hepatitis A virus cellular receptor 2. (301 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
SSC5DScavenger receptor cysteine rich family member with 5 domains. (1419 aa)
LOC100991118DEFENSIN domain-containing protein. (94 aa)
LOC100991783DEFENSIN domain-containing protein. (94 aa)
ENSPPAP00000009556Uncharacterized protein. (124 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
GBP4Guanylate binding protein 4. (640 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
ENSPPAP00000010678Uncharacterized protein. (56 aa)
IL17AInterleukin 17A. (155 aa)
REG3GRegenerating family member 3 gamma. (175 aa)
IL6RInterleukin 6 receptor. (468 aa)
DEFB118Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (123 aa)
FGRTyrosine-protein kinase. (529 aa)
DEFB119Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)
RNASE9Ribonuclease A family member 9 (inactive); Belongs to the pancreatic ribonuclease family. (210 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
DEFB114Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (69 aa)
ZG16Zymogen granule protein 16. (167 aa)
CRPUncharacterized protein. (102 aa)
ANGAngiogenin; Belongs to the pancreatic ribonuclease family. (147 aa)
ENSPPAP0000001930640S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (67 aa)
RNASE12Ribonuclease A family member 12 (inactive); Belongs to the pancreatic ribonuclease family. (147 aa)
RNASE4Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (147 aa)
TAC1Tachykinin precursor 1. (134 aa)
LOC100993063MACPF domain-containing protein. (701 aa)
RNASE7Ribonuclease A family member 7; Belongs to the pancreatic ribonuclease family. (156 aa)
RNASE6Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. (150 aa)
LYG2Lysozyme g-like protein; Belongs to the glycosyl hydrolase 23 family. (212 aa)
PGLYRP2Peptidoglycan recognition protein 2. (633 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
PGLYRP3Peptidoglycan recognition protein 3. (341 aa)
RARRES2Retinoic acid receptor responder 2. (163 aa)
TNFSF8TNF superfamily member 8; Belongs to the tumor necrosis factor family. (234 aa)
PYCARDPYD and CARD domain containing. (195 aa)
STAB2Stabilin 2. (2551 aa)
PPP1R11Protein phosphatase 1 regulatory inhibitor subunit 11. (126 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
RPL39Uncharacterized protein. (51 aa)
C10orf99Chromosome 10 open reading frame 99. (81 aa)
CASP4Caspase 4; Belongs to the peptidase C14A family. (321 aa)
CAMPCathelicidin antimicrobial peptide. (173 aa)
DEFA6Defensin alpha 6. (100 aa)
DEFB1Defensin beta 1. (68 aa)
TNFRSF14TNF receptor superfamily member 14. (283 aa)
MBL2Mannose binding lectin 2. (270 aa)
DCDDermcidin. (110 aa)
FAU40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (136 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
IL7RInterleukin 7 receptor. (459 aa)
IL17FInterleukin 17F. (163 aa)
GBP2Guanylate binding protein 2. (591 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (196 aa)
LYZLysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. (148 aa)
GSDMDGasdermin D. (533 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (352 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
DROSHADrosha ribonuclease III. (1369 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
PLA2G1BPhospholipase A(2). (148 aa)
LBPLipopolysaccharide binding protein. (481 aa)
IL6Uncharacterized protein. (198 aa)
DEFA4Defensin alpha 4. (97 aa)
PLA2G2APhospholipase A(2). (144 aa)
ADMAdrenomedullin. (185 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
ENSPPAP00000001140Uncharacterized protein. (51 aa)
TIRAPTIR domain-containing protein. (226 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (360 aa)
RNASE1Ribonuclease A family member 1, pancreatic; Belongs to the pancreatic ribonuclease family. (156 aa)
EPHA2EPH receptor A2. (976 aa)
NLRP3NLR family pyrin domain containing 3. (1036 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
LCE3CLate cornified envelope 3C. (94 aa)
CHGAChromogranin A. (459 aa)
H2BC10Histone H2B; Belongs to the histone H2B family. (126 aa)
TBK1TANK binding kinase 1. (729 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
RNASE11Ribonuclease A family member 11 (inactive); Belongs to the pancreatic ribonuclease family. (199 aa)
MR1Major histocompatibility complex, class I-related; Belongs to the MHC class I family. (341 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
LOC100985450Histone H2B type 1. (126 aa)
GBP6Guanylate binding protein family member 6. (633 aa)
ENSPPAP00000022875Uncharacterized protein. (107 aa)
LYG1Lysozyme g-like protein; Belongs to the glycosyl hydrolase 23 family. (194 aa)
ENSPPAP00000024365Histone domain-containing protein; Belongs to the histone H2B family. (113 aa)
LOC100979846Histone H2B type 1. (126 aa)
RNASE8Ribonuclease A family member 8; Belongs to the pancreatic ribonuclease family. (155 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
MPEG1Macrophage expressed 1. (716 aa)
LCE3BLate cornified envelope 3B. (95 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC100981154Histone H2B; Belongs to the histone H2B family. (126 aa)
PGLYRP4Peptidoglycan recognition protein 4. (373 aa)
LOC100985433Histone H2B; Belongs to the histone H2B family. (126 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
H2BC6Histone H2B type 1. (126 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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