(51 nodes) Defense response to fungus network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RNASE7	Ribonuclease A family member 7; Belongs to the pancreatic ribonuclease family. (156 aa)
	TAC1	Tachykinin precursor 1. (134 aa)
	LOC100970329	Peptidase S1 domain-containing protein. (145 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	DEFB114	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (69 aa)
	S100A9	Protein S100; Belongs to the S-100 family. (114 aa)
	CLEC7A	C-type lectin domain containing 7A. (247 aa)
	DEFB119	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)
	GNLY	Granulysin. (173 aa)
	IL17A	Interleukin 17A. (155 aa)
	FAM3A	Family with sequence similarity 3 member A. (244 aa)
	CLEC6A	C-type lectin domain containing 6A. (208 aa)
	S100A12	S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
	HRG	Histidine rich glycoprotein. (525 aa)
	LOC100991783	DEFENSIN domain-containing protein. (94 aa)
	LOC100991118	DEFENSIN domain-containing protein. (94 aa)
	IL17RA	Interleukin 17 receptor A. (864 aa)
	HTN1	Histatin 1. (57 aa)
	RNASE8	Ribonuclease A family member 8; Belongs to the pancreatic ribonuclease family. (155 aa)
	LTF	Lactotransferrin; Belongs to the transferrin family. (711 aa)
	CHGA	Chromogranin A. (459 aa)
	CTSG	Cathepsin G; Belongs to the peptidase S1 family. (255 aa)
	NLRP10	NLR family pyrin domain containing 10. (661 aa)
	DEFA4	Defensin alpha 4. (97 aa)
	IL36RN	Interleukin-1. (155 aa)
	IL17RC	Interleukin 17 receptor C. (787 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (93 aa)
	DEFA6	Defensin alpha 6. (100 aa)
	C10orf99	Chromosome 10 open reading frame 99. (81 aa)
	RARRES2	Retinoic acid receptor responder 2. (163 aa)
	SPON2	Spondin 2. (326 aa)
	BCL10	CARD domain-containing protein. (316 aa)
	CLEC4D	C-type lectin domain family 4 member D. (215 aa)
	ZBP1	Z-DNA binding protein 1. (429 aa)
	CLEC4A	C-type lectin domain family 4 member A. (237 aa)
	LEAP2	Liver enriched antimicrobial peptide 2. (77 aa)
	MPO	Myeloperoxidase. (745 aa)
	CARD9	Caspase recruitment domain family member 9. (536 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	HAMP	Hepcidin antimicrobial peptide. (84 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	CALCA	Calcitonin related polypeptide alpha. (141 aa)
	CLEC4E	C-type lectin domain-containing protein. (174 aa)
	DCD	Dermcidin. (110 aa)
	TSLP	Thymic stromal lymphopoietin. (159 aa)
	JAGN1	Jagunal homolog 1. (183 aa)
	CLEC4C	C-type lectin domain family 4 member C. (201 aa)
	ENSPPAP00000021176	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (259 aa)
	COTL1	Coactosin like F-actin binding protein 1. (129 aa)
	HTN3	Histatin 3. (51 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL10	CARD9	ENSPPAP00000032949	ENSPPAP00000030220	CARD domain-containing protein.	Caspase recruitment domain family member 9.	0.999
BCL10	CLEC4E	ENSPPAP00000032949	ENSPPAP00000035528	CARD domain-containing protein.	C-type lectin domain-containing protein.	0.500
BCL10	CLEC6A	ENSPPAP00000032949	ENSPPAP00000010447	CARD domain-containing protein.	C-type lectin domain containing 6A.	0.523
BCL10	CLEC7A	ENSPPAP00000032949	ENSPPAP00000012792	CARD domain-containing protein.	C-type lectin domain containing 7A.	0.639
CALCA	TAC1	ENSPPAP00000034949	ENSPPAP00000019880	Calcitonin related polypeptide alpha.	Tachykinin precursor 1.	0.682
CARD9	BCL10	ENSPPAP00000030220	ENSPPAP00000032949	Caspase recruitment domain family member 9.	CARD domain-containing protein.	0.999
CARD9	CLEC4D	ENSPPAP00000030220	ENSPPAP00000030087	Caspase recruitment domain family member 9.	C-type lectin domain family 4 member D.	0.538
CARD9	CLEC4E	ENSPPAP00000030220	ENSPPAP00000035528	Caspase recruitment domain family member 9.	C-type lectin domain-containing protein.	0.697
CARD9	CLEC6A	ENSPPAP00000030220	ENSPPAP00000010447	Caspase recruitment domain family member 9.	C-type lectin domain containing 6A.	0.700
CARD9	CLEC7A	ENSPPAP00000030220	ENSPPAP00000012792	Caspase recruitment domain family member 9.	C-type lectin domain containing 7A.	0.800
CARD9	IL17A	ENSPPAP00000030220	ENSPPAP00000010972	Caspase recruitment domain family member 9.	Interleukin 17A.	0.461
CARD9	IL17RA	ENSPPAP00000030220	ENSPPAP00000007954	Caspase recruitment domain family member 9.	Interleukin 17 receptor A.	0.425
CHGA	TGFB1	ENSPPAP00000003532	ENSPPAP00000017066	Chromogranin A.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.416
CLEC4A	CLEC6A	ENSPPAP00000029647	ENSPPAP00000010447	C-type lectin domain family 4 member A.	C-type lectin domain containing 6A.	0.465
CLEC4A	CLEC7A	ENSPPAP00000029647	ENSPPAP00000012792	C-type lectin domain family 4 member A.	C-type lectin domain containing 7A.	0.463
CLEC4D	CARD9	ENSPPAP00000030087	ENSPPAP00000030220	C-type lectin domain family 4 member D.	Caspase recruitment domain family member 9.	0.538
CLEC4D	CLEC4E	ENSPPAP00000030087	ENSPPAP00000035528	C-type lectin domain family 4 member D.	C-type lectin domain-containing protein.	0.671
CLEC4D	CLEC6A	ENSPPAP00000030087	ENSPPAP00000010447	C-type lectin domain family 4 member D.	C-type lectin domain containing 6A.	0.798
CLEC4D	CLEC7A	ENSPPAP00000030087	ENSPPAP00000012792	C-type lectin domain family 4 member D.	C-type lectin domain containing 7A.	0.641
CLEC4E	BCL10	ENSPPAP00000035528	ENSPPAP00000032949	C-type lectin domain-containing protein.	CARD domain-containing protein.	0.500