(34 nodes) Negative regulation of antigen receptor-mediated signaling pathway network (Pan paniscus)

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Your Input:
	DUSP22	Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
	PLCL2	Phosphoinositide phospholipase C. (1101 aa)
	LPXN	Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (387 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1313 aa)
	FCRL3	Fc receptor like 3. (742 aa)
	ENSPPAP00000011925	Uncharacterized protein. (383 aa)
	BTN2A2	Butyrophilin subfamily 2 member A2. (523 aa)
	THY1	Thy-1 cell surface antigen. (161 aa)
	LAPTM5	Lysosomal protein transmembrane 5. (262 aa)
	UBASH3A	Ubiquitin associated and SH3 domain containing A. (661 aa)
	CBLB	Cbl proto-oncogene B. (982 aa)
	CD160	Uncharacterized protein. (234 aa)
	ELF1	E74 like ETS transcription factor 1. (619 aa)
	LGALS3	Galectin. (250 aa)
	PRNP	Major prion protein; Belongs to the prion family. (253 aa)
	CEACAM1	Uncharacterized protein. (464 aa)
	GPS2	G protein pathway suppressor 2. (327 aa)
	PTPN22	Protein tyrosine phosphatase non-receptor type 22. (807 aa)
	SLA2	Src like adaptor 2. (261 aa)
	DUSP3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (162 aa)
	EZR	Ezrin. (604 aa)
	CD22	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...] (847 aa)
	LOC100984838	Uncharacterized protein. (334 aa)
	PVRIG	PVR related immunoglobulin domain containing. (326 aa)
	DGKZ	Diacylglycerol kinase. (1117 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (424 aa)
	SH2D1A	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
	CD300A	CD300a molecule. (299 aa)
	LILRB4	Leukocyte immunoglobulin like receptor B4. (408 aa)
	ENSPPAP00000037876	GB1/RHD3-type G domain-containing protein. (492 aa)
	PHPT1	Uncharacterized protein. (101 aa)
	ENSPPAP00000040809	Uncharacterized protein. (297 aa)
	PAWR	Pro-apoptotic WT1 regulator. (320 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBLB	PTPN6	ENSPPAP00000018606	ENSPPAP00000009042	Cbl proto-oncogene B.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.437
CBLB	SLA2	ENSPPAP00000018606	ENSPPAP00000027438	Cbl proto-oncogene B.	Src like adaptor 2.	0.778
CBLB	UBASH3A	ENSPPAP00000018606	ENSPPAP00000017299	Cbl proto-oncogene B.	Ubiquitin associated and SH3 domain containing A.	0.447
CD22	LOC100984838	ENSPPAP00000028870	ENSPPAP00000030168	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	Uncharacterized protein.	0.442
CD22	PTPN6	ENSPPAP00000028870	ENSPPAP00000009042	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.994
CD300A	FCRL3	ENSPPAP00000035496	ENSPPAP00000010725	CD300a molecule.	Fc receptor like 3.	0.426
CD300A	PTPN6	ENSPPAP00000035496	ENSPPAP00000009042	CD300a molecule.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.506
CEACAM1	LGALS3	ENSPPAP00000021898	ENSPPAP00000020404	Uncharacterized protein.	Galectin.	0.419
DUSP3	PTPN2	ENSPPAP00000027615	ENSPPAP00000031649	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Tyrosine-protein phosphatase non-receptor type.	0.482
FCRL3	CD300A	ENSPPAP00000010725	ENSPPAP00000035496	Fc receptor like 3.	CD300a molecule.	0.426
FCRL3	PTPN22	ENSPPAP00000010725	ENSPPAP00000025847	Fc receptor like 3.	Protein tyrosine phosphatase non-receptor type 22.	0.637
LAPTM5	PTPN6	ENSPPAP00000015376	ENSPPAP00000009042	Lysosomal protein transmembrane 5.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.502
LGALS3	CEACAM1	ENSPPAP00000020404	ENSPPAP00000021898	Galectin.	Uncharacterized protein.	0.419
LGALS3	LOC100984838	ENSPPAP00000020404	ENSPPAP00000030168	Galectin.	Uncharacterized protein.	0.834
LILRB4	PTPN6	ENSPPAP00000035770	ENSPPAP00000009042	Leukocyte immunoglobulin like receptor B4.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.609
LOC100984838	CD22	ENSPPAP00000030168	ENSPPAP00000028870	Uncharacterized protein.	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	0.442
LOC100984838	LGALS3	ENSPPAP00000030168	ENSPPAP00000020404	Uncharacterized protein.	Galectin.	0.834
LOC100984838	PTPN6	ENSPPAP00000030168	ENSPPAP00000009042	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.664
LPXN	PTPN22	ENSPPAP00000004444	ENSPPAP00000025847	Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN).	Protein tyrosine phosphatase non-receptor type 22.	0.576
PTPN2	DUSP3	ENSPPAP00000031649	ENSPPAP00000027615	Tyrosine-protein phosphatase non-receptor type.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.482