STRINGSTRING
SPN SPN SOCS5 SOCS5 TNFSF18 TNFSF18 RUNX1 RUNX1 RAG2 RAG2 PRNP PRNP PAG1 PAG1 CTSG CTSG TARM1 TARM1 IL20RB IL20RB ENSPPAP00000004517 ENSPPAP00000004517 LOXL3 LOXL3 IFNL1 IFNL1 TNFAIP8L2 TNFAIP8L2 VTCN1 VTCN1 MDK MDK HAVCR2 HAVCR2 NDFIP1 NDFIP1 LAG3 LAG3 SDC4 SDC4 IL4 IL4 MARCHF7 MARCHF7 PTPN6 PTPN6 ZC3H8 ZC3H8 FOXP3 FOXP3 LRRC32 LRRC32 PLA2G2F PLA2G2F TWSG1 TWSG1 BMP4 BMP4 BCL6 BCL6 IDO1 IDO1 PTEN PTEN SCRIB SCRIB LAX1 LAX1 CASP3 CASP3 BTN2A2 BTN2A2 TNFRSF21 TNFRSF21 IL2 IL2 ANXA1 ANXA1 PDCD1LG2 PDCD1LG2 LAPTM5 LAPTM5 HLA-G HLA-G PLA2G2D PLA2G2D SMAD7 SMAD7 ARG1 ARG1 VSIR VSIR GPNMB GPNMB TGFB1 TGFB1 HLX HLX TNFSF4 TNFSF4 ADORA2A ADORA2A CBLB CBLB SOCS6 SOCS6 PRKAR1A PRKAR1A FGL1 FGL1 LGALS3 LGALS3 SHH SHH FGL2 FGL2 DLG1 DLG1 CD86 CD86 ENSPPAP00000021246 ENSPPAP00000021246 VSIG4 VSIG4 TBX21 TBX21 IHH IHH CEACAM1 CEACAM1 LRRC1 LRRC1 PRDX2 PRDX2 CD274 CD274 RUNX3 RUNX3 ENSPPAP00000023714 ENSPPAP00000023714 CLEC4G CLEC4G ZBTB7B ZBTB7B TMEM131L TMEM131L RC3H2 RC3H2 PTPN22 PTPN22 IRF1 IRF1 FOXJ1 FOXJ1 ICOSLG ICOSLG IL2RA IL2RA DUSP3 DUSP3 SCGB1A1 SCGB1A1 ILDR2 ILDR2 ENSPPAP00000028807 ENSPPAP00000028807 CD74 CD74 LOC100984838 LOC100984838 CDKN2A CDKN2A NCKAP1L NCKAP1L PTPN2 PTPN2 RC3H1 RC3H1 CD80 CD80 LOC100995377 LOC100995377 GLMN GLMN LOC100991923 LOC100991923 IL4I1 IL4I1 SFTPD SFTPD LGALS9 LGALS9 CD300A CD300A LILRB4 LILRB4 TSPAN32 TSPAN32 JAK3 JAK3 CRTAM CRTAM ZC3H12A ZC3H12A PDE5A PDE5A TNFRSF14 TNFRSF14 ERBB2 ERBB2 IL4R IL4R CTLA4 CTLA4 DLG5 DLG5 HFE HFE GIMAP1 GIMAP1 LOC100981622 LOC100981622 ARG2 ARG2 GLI3 GLI3 MAD1L1 MAD1L1 ITCH ITCH TIGIT TIGIT PAWR PAWR DUSP22 DUSP22 PELI1 PELI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPNSialophorin. (400 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
TNFSF18TNF superfamily member 18. (199 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
RAG2Recombination activating 2. (527 aa)
PRNPMajor prion protein; Belongs to the prion family. (253 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (432 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
TARM1T cell-interacting, activating receptor on myeloid cells 1. (273 aa)
IL20RBInterleukin 20 receptor subunit beta. (281 aa)
ENSPPAP00000004517Uncharacterized protein. (654 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
IFNL1Interferon lambda 1. (200 aa)
TNFAIP8L2TNF alpha induced protein 8 like 2. (184 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (285 aa)
MDKMidkine. (143 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (301 aa)
NDFIP1Nedd4 family interacting protein 1. (200 aa)
LAG3Lymphocyte activating 3. (527 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (199 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (704 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
ZC3H8Zinc finger CCCH-type containing 8. (291 aa)
FOXP3Forkhead box P3. (441 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
PLA2G2FPhospholipase A(2). (211 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
BCL6BCL6 transcription repressor. (706 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (403 aa)
PTENUncharacterized protein. (542 aa)
SCRIBScribble planar cell polarity protein. (1656 aa)
LAX1Lymphocyte transmembrane adaptor 1. (398 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
BTN2A2Butyrophilin subfamily 2 member A2. (523 aa)
TNFRSF21TNF receptor superfamily member 21. (655 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
ANXA1Annexin. (346 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (273 aa)
LAPTM5Lysosomal protein transmembrane 5. (262 aa)
HLA-GMajor histocompatibility complex, class I, G; Belongs to the MHC class I family. (355 aa)
PLA2G2DPhospholipase A(2). (161 aa)
SMAD7MH2 domain-containing protein. (211 aa)
ARG1Arginase. (322 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
GPNMBGlycoprotein nmb. (574 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HLXH2.0 like homeobox. (493 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
CBLBCbl proto-oncogene B. (982 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
FGL1Fibrinogen like 1. (312 aa)
LGALS3Galectin. (250 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
FGL2Fibrinogen like 2. (439 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
CD86CD86 molecule. (329 aa)
ENSPPAP00000021246SOCS box domain-containing protein. (478 aa)
VSIG4V-set and immunoglobulin domain containing 4. (399 aa)
TBX21T-box transcription factor 21. (494 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (402 aa)
CEACAM1Uncharacterized protein. (464 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
PRDX2Peroxiredoxin 2. (198 aa)
CD274CD274 molecule. (290 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
ENSPPAP00000023714Uncharacterized protein. (82 aa)
CLEC4GC-type lectin domain family 4 member G. (272 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
TMEM131LTransmembrane 131 like. (1617 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (807 aa)
IRF1Interferon regulatory factor. (325 aa)
FOXJ1Forkhead box J1. (405 aa)
ICOSLGUncharacterized protein. (463 aa)
IL2RASushi domain-containing protein. (249 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (162 aa)
SCGB1A1Secretoglobin family 1A member 1. (91 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (620 aa)
ENSPPAP00000028807Thioredoxin domain-containing protein. (166 aa)
CD74CD74 molecule. (296 aa)
LOC100984838Uncharacterized protein. (334 aa)
CDKN2AUncharacterized protein. (173 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (424 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
CD80CD80 molecule. (288 aa)
LOC100995377Uncharacterized protein. (557 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
LOC100991923Galectin. (111 aa)
IL4I1Amine oxidase. (589 aa)
SFTPDSurfactant protein D. (375 aa)
LGALS9Galectin. (355 aa)
CD300ACD300a molecule. (299 aa)
LILRB4Leukocyte immunoglobulin like receptor B4. (408 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (320 aa)
JAK3Tyrosine-protein kinase. (1090 aa)
CRTAMCytotoxic and regulatory T cell molecule. (393 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
PDE5APhosphodiesterase. (875 aa)
TNFRSF14TNF receptor superfamily member 14. (283 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
IL4RInterleukin 4 receptor. (873 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1809 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
GIMAP1Uncharacterized protein. (500 aa)
LOC100981622Galectin. (136 aa)
ARG2Arginase. (354 aa)
GLI3GLI family zinc finger 3. (1580 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
ITCHE3 ubiquitin-protein ligase. (870 aa)
TIGITT cell immunoreceptor with Ig and ITIM domains. (290 aa)
PAWRPro-apoptotic WT1 regulator. (320 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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