(32 nodes) Brown fat cell differentiation network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100980957	Uncharacterized protein. (210 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	FFAR4	Free fatty acid receptor 4. (377 aa)
	CEBPA	BZIP domain-containing protein. (141 aa)
	ARL4A	ADP ribosylation factor like GTPase 4A. (200 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
	GATA2	GATA binding protein 2. (480 aa)
	LAMB3	Laminin subunit beta 3. (1171 aa)
	LRG1	Leucine rich alpha-2-glycoprotein 1. (347 aa)
	ENSPPAP00000012875	Uncharacterized protein. (76 aa)
	FABP3	Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
	ALDH6A1	Aldehyde dehydrogenase 6 family member A1. (535 aa)
	PRDM16	PR/SET domain 16. (1324 aa)
	EBF2	EBF transcription factor 2. (575 aa)
	ZNF516	Zinc finger protein 516. (1145 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	ADIG	Adipogenin. (79 aa)
	PLAC8	Placenta associated 8. (115 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (809 aa)
	ENSPPAP00000023286	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (140 aa)
	ERO1A	Endoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
	RGS2	Regulator of G protein signaling 2. (211 aa)
	ADRB2	Adrenoceptor beta 2. (429 aa)
	PEX11A	Peroxisomal biogenesis factor 11 alpha. (247 aa)
	DIO2	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (145 aa)
	LAMA4	Laminin subunit alpha 4. (1823 aa)
	NUDT7	Nudix hydrolase 7. (222 aa)
	METRNL	Uncharacterized protein. (331 aa)
	BNIP3	BCL2 interacting protein 3. (252 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	DHRS7B	Dehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (286 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIG	ADIPOQ	ENSPPAP00000021697	ENSPPAP00000042063	Adipogenin.	Adiponectin, C1Q and collagen domain containing.	0.402
ADIPOQ	ADIG	ENSPPAP00000042063	ENSPPAP00000021697	Adiponectin, C1Q and collagen domain containing.	Adipogenin.	0.402
ADIPOQ	CEBPA	ENSPPAP00000042063	ENSPPAP00000003416	Adiponectin, C1Q and collagen domain containing.	BZIP domain-containing protein.	0.815
ADIPOQ	FABP4	ENSPPAP00000042063	ENSPPAP00000019143	Adiponectin, C1Q and collagen domain containing.	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.803
ADIPOQ	PPARGC1A	ENSPPAP00000042063	ENSPPAP00000023052	Adiponectin, C1Q and collagen domain containing.	PPARG coactivator 1 alpha.	0.765
ADIPOQ	PRDM16	ENSPPAP00000042063	ENSPPAP00000014446	Adiponectin, C1Q and collagen domain containing.	PR/SET domain 16.	0.534
ADIPOQ	SLC2A4	ENSPPAP00000042063	ENSPPAP00000001068	Adiponectin, C1Q and collagen domain containing.	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.705
ADIPOQ	UCP1	ENSPPAP00000042063	ENSPPAP00000008833	Adiponectin, C1Q and collagen domain containing.	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.741
BNIP3	PPARGC1A	ENSPPAP00000040465	ENSPPAP00000023052	BCL2 interacting protein 3.	PPARG coactivator 1 alpha.	0.459
CEBPA	ADIPOQ	ENSPPAP00000003416	ENSPPAP00000042063	BZIP domain-containing protein.	Adiponectin, C1Q and collagen domain containing.	0.815
CEBPA	FABP4	ENSPPAP00000003416	ENSPPAP00000019143	BZIP domain-containing protein.	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.742
CEBPA	GATA2	ENSPPAP00000003416	ENSPPAP00000009054	BZIP domain-containing protein.	GATA binding protein 2.	0.771
CEBPA	PPARGC1A	ENSPPAP00000003416	ENSPPAP00000023052	BZIP domain-containing protein.	PPARG coactivator 1 alpha.	0.667
CEBPA	PRDM16	ENSPPAP00000003416	ENSPPAP00000014446	BZIP domain-containing protein.	PR/SET domain 16.	0.591
CEBPA	SLC2A4	ENSPPAP00000003416	ENSPPAP00000001068	BZIP domain-containing protein.	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.803
CEBPA	UCP1	ENSPPAP00000003416	ENSPPAP00000008833	BZIP domain-containing protein.	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.538
DIO2	PPARGC1A	ENSPPAP00000028884	ENSPPAP00000023052	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	PPARG coactivator 1 alpha.	0.550
DIO2	PRDM16	ENSPPAP00000028884	ENSPPAP00000014446	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	PR/SET domain 16.	0.570
DIO2	UCP1	ENSPPAP00000028884	ENSPPAP00000008833	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.678
EBF2	PPARGC1A	ENSPPAP00000015031	ENSPPAP00000023052	EBF transcription factor 2.	PPARG coactivator 1 alpha.	0.413