STRINGSTRING
ESR1 ESR1 DDAH2 DDAH2 ENSPPAP00000004239 ENSPPAP00000004239 NUS1 NUS1 HTR2B HTR2B CNR2 CNR2 SCARB1 SCARB1 LOC100982471 LOC100982471 EGFR EGFR FCER2 FCER2 ACVR2A ACVR2A TERF2 TERF2 NOS1AP NOS1AP CAV3 CAV3 ATP2B4 ATP2B4 GCH1 GCH1 AKT1 AKT1 IL1B IL1B S100A1 S100A1 ZDHHC21 ZDHHC21 PTK2B PTK2B CALM3 CALM3 CAV1 CAV1 LEP LEP NOSIP NOSIP IL1A IL1A DDAH1 DDAH1 PIK3CB PIK3CB ENG ENG NPR3 NPR3 TERT TERT ENSPPAP00000011507 ENSPPAP00000011507 GLA GLA HIF1A HIF1A NOD1 NOD1 DHFR DHFR AGTR2 AGTR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
DDAH2Dimethylarginine dimethylaminohydrolase 2. (287 aa)
ENSPPAP00000004239Uncharacterized protein. (268 aa)
NUS1Uncharacterized protein. (220 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
CNR2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
SCARB1Uncharacterized protein; Belongs to the CD36 family. (498 aa)
LOC100982471Uncharacterized protein; Belongs to the calmodulin family. (93 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
FCER2Fc fragment of IgE receptor II. (321 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (472 aa)
NOS1APNitric oxide synthase 1 adaptor protein. (506 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
GCH1GTP cyclohydrolase 1. (250 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
S100A1Protein S100; Belongs to the S-100 family. (147 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
NOSIPNitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family. (304 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
DDAH1Uncharacterized protein. (182 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ENGEndoglin. (658 aa)
NPR3Natriuretic peptide receptor 3. (532 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1040 aa)
ENSPPAP00000011507Uncharacterized protein. (290 aa)
GLAAlpha-galactosidase. (429 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
DHFRDihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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