STRINGSTRING
FBL FBL RALA RALA TRPC1 TRPC1 ATXN3 ATXN3 NKAIN2 NKAIN2 ATP6V1G1 ATP6V1G1 SLC26A9 SLC26A9 FXYD3 FXYD3 PLN PLN SYVN1 SYVN1 ESR1 ESR1 SNU13 SNU13 NR1H2 NR1H2 NUFIP1 NUFIP1 TOR1AIP1 TOR1AIP1 TMTC4 TMTC4 NPLOC4 NPLOC4 ENSPPAP00000010591 ENSPPAP00000010591 ENSPPAP00000010638 ENSPPAP00000010638 RAB3A RAB3A SNTA1 SNTA1 ENSPPAP00000013091 ENSPPAP00000013091 TCIRG1 TCIRG1 TMEM106B TMEM106B DNAJB1 DNAJB1 SELENOS SELENOS SNURF SNURF BRSK2 BRSK2 ANK1 ANK1 PKD2 PKD2 LCK LCK HRC HRC ENSPPAP00000017113 ENSPPAP00000017113 LHCGR LHCGR ATP6V0A4 ATP6V0A4 NCSTN NCSTN GABARAPL2 GABARAPL2 ADCY10 ADCY10 ATP6V1G3 ATP6V1G3 YIPF7 YIPF7 NKD2 NKD2 ATP6V0A1 ATP6V0A1 TRPC5 TRPC5 VCPKMT VCPKMT ENSPPAP00000024159 ENSPPAP00000024159 PIH1D1 PIH1D1 SDF2L1 SDF2L1 TMEM106A TMEM106A ATP1B2 ATP1B2 RALB RALB ATP1B1 ATP1B1 NOP58 NOP58 UBXN1 UBXN1 CAV1 CAV1 ATP6V0A2 ATP6V0A2 EZR EZR ATP6V1E1 ATP6V1E1 ENSPPAP00000029844 ENSPPAP00000029844 ANK2 ANK2 ALDOB ALDOB RUVBL2 RUVBL2 SNX10 SNX10 PEX19 PEX19 PSEN1 PSEN1 WFS1 WFS1 AR AR PELP1 PELP1 ENSPPAP00000031925 ENSPPAP00000031925 ATP1B3 ATP1B3 TOR1AIP2 TOR1AIP2 SLC2A13 SLC2A13 S100A1 S100A1 USP25 USP25 BBC3 BBC3 RUVBL1 RUVBL1 LOC100995958 LOC100995958 ABCA1 ABCA1 DNAJC10 DNAJC10 RDX RDX SRC SRC CLPP CLPP YIPF5 YIPF5 METTL21A METTL21A PDE4D PDE4D SVIP SVIP PPP3CA PPP3CA ATP5IF1 ATP5IF1 DERL1 DERL1 ENSPPAP00000041535 ENSPPAP00000041535 PTPN3 PTPN3 ZNHIT6 ZNHIT6 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBLFibrillarin. (336 aa)
RALARAS like proto-oncogene A. (206 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
ATXN3Josephin domain-containing protein. (312 aa)
NKAIN2Sodium/potassium transporting ATPase interacting 2. (208 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
SLC26A9Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (887 aa)
FXYD3FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (144 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
SYVN1Synoviolin 1. (625 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
SNU13Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (132 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
NUFIP1Nuclear FMR1 interacting protein 1. (494 aa)
TOR1AIP1Torsin 1A interacting protein 1. (599 aa)
TMTC4Transmembrane O-mannosyltransferase targeting cadherins 4. (760 aa)
NPLOC4NPL4 homolog, ubiquitin recognition factor. (609 aa)
ENSPPAP00000010591Uncharacterized protein. (186 aa)
ENSPPAP00000010638Uncharacterized protein. (172 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
SNTA1Syntrophin alpha 1. (431 aa)
ENSPPAP00000013091Uncharacterized protein. (176 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
TMEM106BTransmembrane protein 106B. (274 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (367 aa)
SELENOSUncharacterized protein. (218 aa)
SNURFUncharacterized protein. (81 aa)
BRSK2BR serine/threonine kinase 2. (707 aa)
ANK1Ankyrin 1. (1897 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (788 aa)
LCKTyrosine-protein kinase. (524 aa)
HRCHistidine rich calcium binding protein. (683 aa)
ENSPPAP00000017113V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (77 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (782 aa)
NCSTNNicastrin. (709 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
ADCY10Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1610 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (124 aa)
YIPF7Protein YIPF. (280 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (416 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (973 aa)
VCPKMTValosin containing protein lysine methyltransferase. (229 aa)
ENSPPAP00000024159Uncharacterized protein. (218 aa)
PIH1D1PIH1 domain containing 1. (321 aa)
SDF2L1Stromal cell derived factor 2 like 1. (221 aa)
TMEM106ATransmembrane protein 106A. (262 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (267 aa)
RALBRAS like proto-oncogene B. (254 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
NOP58NOP58 ribonucleoprotein. (539 aa)
UBXN1UBX domain protein 1. (310 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
EZREzrin. (604 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
ENSPPAP00000029844Uncharacterized protein. (229 aa)
ANK2Ankyrin 2. (3957 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
SNX10Sorting nexin 10. (168 aa)
PEX19Uncharacterized protein. (299 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
ARAndrogen receptor. (882 aa)
PELP1Proline, glutamate and leucine rich protein 1. (1178 aa)
ENSPPAP00000031925FERM domain-containing protein. (502 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (242 aa)
TOR1AIP2Torsin 1A interacting protein 2. (470 aa)
SLC2A13Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (587 aa)
S100A1Protein S100; Belongs to the S-100 family. (147 aa)
USP25Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1174 aa)
BBC3Uncharacterized protein. (131 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
LOC100995958Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (268 aa)
ABCA1ATP binding cassette subfamily A member 1. (2264 aa)
DNAJC10DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (793 aa)
RDXRadixin. (609 aa)
SRCTyrosine-protein kinase. (458 aa)
CLPPATP-dependent Clp protease proteolytic subunit. (277 aa)
YIPF5Protein YIPF. (257 aa)
METTL21AMethyltransferase like 21A. (236 aa)
PDE4DPhosphodiesterase. (706 aa)
SVIPSmall VCP interacting protein. (77 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
ENSPPAP00000041535J domain-containing protein. (478 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (878 aa)
ZNHIT6Zinc finger HIT-type containing 6. (470 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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