STRINGSTRING
HTR2A HTR2A SLC8A1 SLC8A1 GP9 GP9 CCR5 CCR5 TRPC1 TRPC1 TMEM38A TMEM38A TRPV1 TRPV1 APLNR APLNR BDKRB1 BDKRB1 XCR1 XCR1 LOC100982471 LOC100982471 MTLN MTLN CCL21 CCL21 PRKACA PRKACA DRD1 DRD1 HTR2B HTR2B FLNA FLNA LOC100986914 LOC100986914 P2RX7 P2RX7 MCOLN3 MCOLN3 PLN PLN ENSPPAP00000005183 ENSPPAP00000005183 SRI SRI LETM1 LETM1 P2RY6 P2RY6 SNCA SNCA IBTK IBTK METTL21C METTL21C PTPN6 PTPN6 ITPR2 ITPR2 HAP1 HAP1 CASQ2 CASQ2 FASLG FASLG ENSPPAP00000011278 ENSPPAP00000011278 CD19 CD19 HTT HTT CHERP CHERP DHRS7C DHRS7C GSTO1 GSTO1 DIAPH1 DIAPH1 JPH2 JPH2 THY1 THY1 ITGB3 ITGB3 LYN LYN F2RL3 F2RL3 CAMK2D CAMK2D PKD2 PKD2 TPCN2 TPCN2 LCK LCK CACNA1C CACNA1C UBASH3B UBASH3B CXCL11 CXCL11 HRC HRC RYR3 RYR3 TGFB1 TGFB1 CORO1A CORO1A TRPA1 TRPA1 PLCG1 PLCG1 LHCGR LHCGR SELENON SELENON CASQ1 CASQ1 JPH1 JPH1 ANXA6 ANXA6 ENSPPAP00000018672 ENSPPAP00000018672 RASA3 RASA3 PRKCE PRKCE RYR1 RYR1 CCL19 CCL19 CHD7 CHD7 TMEM38B TMEM38B DDIT3 DDIT3 ATP1A2 ATP1A2 PTPRC PTPRC CAPN3 CAPN3 ENSPPAP00000022875 ENSPPAP00000022875 F2R F2R FKBP1B FKBP1B MCOLN2 MCOLN2 MCOLN1 MCOLN1 TPCN1 TPCN1 ERO1A ERO1A ABL1 ABL1 ASPH ASPH CX3CL1 CX3CL1 TRPM2 TRPM2 AKAP6 AKAP6 GP5 GP5 PRKD1 PRKD1 SLC8B1 SLC8B1 CALM3 CALM3 LIME1 LIME1 PTK2B PTK2B ANK2 ANK2 CXCL10 CXCL10 ENSPPAP00000030781 ENSPPAP00000030781 CEMIP CEMIP JPH4 JPH4 CXCL9 CXCL9 PLCG2 PLCG2 BBC3 BBC3 BAX BAX SLC25A23 SLC25A23 ITPR3 ITPR3 ATG5 ATG5 NOL3 NOL3 ITPR1 ITPR1 JPH3 JPH3 CLIC2 CLIC2 F2 F2 PDE4D PDE4D HTR2C HTR2C CXCR3 CXCR3 CCR7 CCR7 DMD DMD NTSR1 NTSR1 LACRT LACRT NPSR1 NPSR1 NOS1 NOS1 RYR2 RYR2 JSRP1 JSRP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
GP9Glycoprotein IX platelet. (177 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
TMEM38ATransmembrane protein 38A. (299 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
BDKRB1G_PROTEIN_RECEP_F1_2 domain-containing protein. (284 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
LOC100982471Uncharacterized protein; Belongs to the calmodulin family. (93 aa)
MTLNMitoregulin. (139 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
FLNAUncharacterized protein. (2188 aa)
LOC100986914Uncharacterized protein. (210 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
MCOLN3Mucolipin 3. (554 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ENSPPAP00000005183Letm1 RBD domain-containing protein. (649 aa)
SRISorcin. (195 aa)
LETM1Leucine zipper and EF-hand containing transmembrane protein 1. (722 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
IBTKInhibitor of Bruton tyrosine kinase. (1353 aa)
METTL21CMethyltransferase like 21C. (284 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa)
HAP1Huntingtin associated protein 1. (669 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
ENSPPAP00000011278Protein kinase domain-containing protein. (351 aa)
CD19CD19 molecule. (545 aa)
HTTHuntingtin. (3053 aa)
CHERPCalcium homeostasis endoplasmic reticulum protein. (928 aa)
DHRS7CDehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
DIAPH1FH2 domain-containing protein. (507 aa)
JPH2Uncharacterized protein. (129 aa)
THY1Thy-1 cell surface antigen. (161 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
LYNTyrosine-protein kinase. (526 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (385 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (788 aa)
TPCN2Two pore segment channel 2. (752 aa)
LCKTyrosine-protein kinase. (524 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
CXCL11C-X-C motif chemokine. (94 aa)
HRCHistidine rich calcium binding protein. (683 aa)
RYR3Ryanodine receptor 3. (4835 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1109 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1248 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
SELENONSelenoprotein N. (495 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
JPH1Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (684 aa)
ANXA6Annexin. (788 aa)
ENSPPAP00000018672EF-hand domain-containing protein. (78 aa)
RASA3RAS p21 protein activator 3. (834 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
RYR1Ryanodine receptor 1. (4924 aa)
CCL19C-C motif chemokine. (98 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1261 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
ENSPPAP00000022875Uncharacterized protein. (107 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
MCOLN2Mucolipin 2. (566 aa)
MCOLN1Mucolipin 1. (580 aa)
TPCN1Two pore segment channel 1. (888 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ASPHAspartate beta-hydroxylase. (729 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1552 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
GP5Glycoprotein V platelet. (460 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (584 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
LIME1Uncharacterized protein. (291 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ANK2Ankyrin 2. (3957 aa)
CXCL10C-X-C motif chemokine. (96 aa)
ENSPPAP00000030781Uncharacterized protein. (88 aa)
CEMIPCell migration inducing hyaluronidase 1. (1361 aa)
JPH4Junctophilin 4. (564 aa)
CXCL9C-X-C motif chemokine. (125 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
BBC3Uncharacterized protein. (131 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
SLC25A23Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (468 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
NOL3CARD domain-containing protein. (219 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa)
JPH3Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (748 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
PDE4DPhosphodiesterase. (706 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (372 aa)
DMDDystrophin. (3517 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (405 aa)
LACRTLacritin. (137 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (393 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1403 aa)
RYR2Ryanodine receptor 2. (4948 aa)
JSRP1Uncharacterized protein. (253 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (20%) [HD]