(57 nodes) Regulation of filopodium assembly network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPPAP00000019366	Uncharacterized protein. (154 aa)
	LOC100993131	Cell division control protein 42 homolog. (191 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	ENSPPAP00000024234	Uncharacterized protein. (152 aa)
	PLPPR5	Phospholipid phosphatase related 5. (321 aa)
	DPYSL3	Dihydropyrimidinase like 3. (684 aa)
	NRXN1	Neurexin 1. (1445 aa)
	TENM2	Teneurin transmembrane protein 2. (2774 aa)
	ENSPPAP00000025597	Uncharacterized protein. (154 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1552 aa)
	WASL	WASP like actin nucleation promoting factor. (474 aa)
	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1448 aa)
	FXR1	Uncharacterized protein. (782 aa)
	RAB3IP	RAB3A interacting protein. (476 aa)
	MIEN1	Migration and invasion enhancer 1. (115 aa)
	ARHGAP44	Rho GTPase activating protein 44. (811 aa)
	GPM6A	Glycoprotein M6A. (278 aa)
	ABITRAM	Actin binding transcription modulator. (181 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (924 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	ENSPPAP00000001268	DHR-2 domain-containing protein; Belongs to the DOCK family. (503 aa)
	CCL21	C-C motif chemokine ligand 21. (134 aa)
	TENM1	Teneurin transmembrane protein 1. (2732 aa)
	DAAM2	Dishevelled associated activator of morphogenesis 2. (1077 aa)
	CAPZB	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (301 aa)
	DOCK11	Dedicator of cytokinesis 11; Belongs to the DOCK family. (2073 aa)
	PPP1R16B	Protein phosphatase 1 regulatory subunit 16B. (567 aa)
	MYO3B	Myosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1139 aa)
	ENSPPAP00000010591	Uncharacterized protein. (186 aa)
	ENSPPAP00000039413	Uncharacterized protein. (181 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	FMR1	Fragile X mental retardation 1. (615 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
	RAB5A	RAB5A, member RAS oncogene family. (216 aa)
	RAB17	RAB17, member RAS oncogene family. (211 aa)
	FXR2	FMR1 autosomal homolog 2. (652 aa)
	FNBP1L	Formin binding protein 1 like. (611 aa)
	NLGN1	Neuroligin 1. (823 aa)
	BCAS3	BCAS3 microtubule associated cell migration factor. (950 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	DNM3	Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
	CDC42	Uncharacterized protein. (191 aa)
	RHOQ	Uncharacterized protein. (345 aa)
	AGRN	Agrin. (1816 aa)
	ENSPPAP00000037516	Uncharacterized protein. (321 aa)
	DMTN	Dematin actin binding protein. (405 aa)
	FSCN1	Uncharacterized protein. (316 aa)
	MYO3A	Myosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1621 aa)
	EPHB2	EPH receptor B2. (1039 aa)
	ARF6	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	SRF	Serum response factor. (414 aa)
	ENSPPAP00000010638	Uncharacterized protein. (172 aa)
	PALM	Paralemmin. (314 aa)
	MYO10	Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2027 aa)
	STAU2	Staufen double-stranded RNA binding protein 2. (608 aa)
	GAP43	Growth associated protein 43. (228 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRN	NRXN1	ENSPPAP00000016637	ENSPPAP00000034598	Agrin.	Neurexin 1.	0.461
ARAP1	CDC42	ENSPPAP00000028327	ENSPPAP00000015981	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1.	Uncharacterized protein.	0.456
ARAP1	LOC100993131	ENSPPAP00000028327	ENSPPAP00000017950	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1.	Cell division control protein 42 homolog.	0.456
ARF6	WASL	ENSPPAP00000020137	ENSPPAP00000027723	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	WASP like actin nucleation promoting factor.	0.402
ARHGAP44	CDC42	ENSPPAP00000041288	ENSPPAP00000015981	Rho GTPase activating protein 44.	Uncharacterized protein.	0.427
ARHGAP44	ENSPPAP00000025597	ENSPPAP00000041288	ENSPPAP00000025597	Rho GTPase activating protein 44.	Uncharacterized protein.	0.421
ARHGAP44	ENSPPAP00000039413	ENSPPAP00000041288	ENSPPAP00000039413	Rho GTPase activating protein 44.	Uncharacterized protein.	0.421
ARHGAP44	LOC100993131	ENSPPAP00000041288	ENSPPAP00000017950	Rho GTPase activating protein 44.	Cell division control protein 42 homolog.	0.427
CAPZB	CDC42	ENSPPAP00000007348	ENSPPAP00000015981	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Uncharacterized protein.	0.461
CAPZB	ENSPPAP00000025597	ENSPPAP00000007348	ENSPPAP00000025597	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Uncharacterized protein.	0.461
CAPZB	ENSPPAP00000039413	ENSPPAP00000007348	ENSPPAP00000039413	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Uncharacterized protein.	0.461
CAPZB	LOC100993131	ENSPPAP00000007348	ENSPPAP00000017950	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Cell division control protein 42 homolog.	0.461
CAPZB	WASL	ENSPPAP00000007348	ENSPPAP00000027723	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	WASP like actin nucleation promoting factor.	0.446
CCL21	CCR7	ENSPPAP00000003129	ENSPPAP00000039258	C-C motif chemokine ligand 21.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.998
CCR7	CCL21	ENSPPAP00000039258	ENSPPAP00000003129	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine ligand 21.	0.998
CDC42	ARAP1	ENSPPAP00000015981	ENSPPAP00000028327	Uncharacterized protein.	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1.	0.456
CDC42	ARHGAP44	ENSPPAP00000015981	ENSPPAP00000041288	Uncharacterized protein.	Rho GTPase activating protein 44.	0.427
CDC42	CAPZB	ENSPPAP00000015981	ENSPPAP00000007348	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.461
CDC42	DAAM2	ENSPPAP00000015981	ENSPPAP00000006145	Uncharacterized protein.	Dishevelled associated activator of morphogenesis 2.	0.429
CDC42	DOCK11	ENSPPAP00000015981	ENSPPAP00000008193	Uncharacterized protein.	Dedicator of cytokinesis 11; Belongs to the DOCK family.	0.683