(29 nodes) Cardiac muscle tissue growth network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GATA4	GATA binding protein 4. (396 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1224 aa)
	S1PR1	Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
	GATA6	Uncharacterized protein. (402 aa)
	CXADR	CXADR Ig-like cell adhesion molecule. (352 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (861 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	SORBS2	Sorbin and SH3 domain containing 2. (1202 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	NKX2-5	NK2 homeobox 5. (325 aa)
	DIPK2A	Divergent protein kinase domain 2A. (423 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
	PDLIM5	PDZ and LIM domain 5. (625 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	MAPK11	Mitogen-activated protein kinase. (325 aa)
	NDRG4	NDRG family member 4. (391 aa)
	ENSPPAP00000031014	Protein kinase domain-containing protein. (371 aa)
	NOTCH1	Notch receptor 1. (2573 aa)
	AKAP13	A-kinase anchoring protein 13. (2813 aa)
	HEG1	Heart development protein with EGF like domains 1. (1275 aa)
	TENM4	Teneurin transmembrane protein 4. (2769 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	ARID2	AT-rich interaction domain 2. (1835 aa)
	ADRA1A	Adrenoceptor alpha 1A. (495 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP10	NKX2-5	ENSPPAP00000037922	ENSPPAP00000015856	Bone morphogenetic protein 10.	NK2 homeobox 5.	0.511
FGF9	GATA4	ENSPPAP00000000980	ENSPPAP00000000601	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GATA binding protein 4.	0.523
GATA4	FGF9	ENSPPAP00000000601	ENSPPAP00000000980	GATA binding protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.523
GATA4	GATA6	ENSPPAP00000000601	ENSPPAP00000003349	GATA binding protein 4.	Uncharacterized protein.	0.496
GATA4	HEY2	ENSPPAP00000000601	ENSPPAP00000022023	GATA binding protein 4.	Hes related family bHLH transcription factor with YRPW motif 2.	0.588
GATA4	JARID2	ENSPPAP00000000601	ENSPPAP00000002673	GATA binding protein 4.	Jumonji and AT-rich interaction domain containing 2.	0.631
GATA4	NKX2-5	ENSPPAP00000000601	ENSPPAP00000015856	GATA binding protein 4.	NK2 homeobox 5.	0.997
GATA4	TBX5	ENSPPAP00000000601	ENSPPAP00000012540	GATA binding protein 4.	T-box transcription factor 5.	0.942
GATA6	GATA4	ENSPPAP00000003349	ENSPPAP00000000601	Uncharacterized protein.	GATA binding protein 4.	0.496
GATA6	NKX2-5	ENSPPAP00000003349	ENSPPAP00000015856	Uncharacterized protein.	NK2 homeobox 5.	0.817
GATA6	TBX5	ENSPPAP00000003349	ENSPPAP00000012540	Uncharacterized protein.	T-box transcription factor 5.	0.576
HEG1	NOTCH1	ENSPPAP00000036658	ENSPPAP00000033437	Heart development protein with EGF like domains 1.	Notch receptor 1.	0.414
HEY2	GATA4	ENSPPAP00000022023	ENSPPAP00000000601	Hes related family bHLH transcription factor with YRPW motif 2.	GATA binding protein 4.	0.588
HEY2	NKX2-5	ENSPPAP00000022023	ENSPPAP00000015856	Hes related family bHLH transcription factor with YRPW motif 2.	NK2 homeobox 5.	0.541
HEY2	NOTCH1	ENSPPAP00000022023	ENSPPAP00000033437	Hes related family bHLH transcription factor with YRPW motif 2.	Notch receptor 1.	0.774
HEY2	TBX5	ENSPPAP00000022023	ENSPPAP00000012540	Hes related family bHLH transcription factor with YRPW motif 2.	T-box transcription factor 5.	0.543
JARID2	GATA4	ENSPPAP00000002673	ENSPPAP00000000601	Jumonji and AT-rich interaction domain containing 2.	GATA binding protein 4.	0.631
JARID2	NKX2-5	ENSPPAP00000002673	ENSPPAP00000015856	Jumonji and AT-rich interaction domain containing 2.	NK2 homeobox 5.	0.499
JARID2	TBX5	ENSPPAP00000002673	ENSPPAP00000012540	Jumonji and AT-rich interaction domain containing 2.	T-box transcription factor 5.	0.500
MAP2K4	MAPK11	ENSPPAP00000009646	ENSPPAP00000025888	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.930