STRINGSTRING
ENSPPAP00000002253 ENSPPAP00000002253 TMEM199 TMEM199 GDF2 GDF2 STEAP2 STEAP2 ENSPPAP00000003604 ENSPPAP00000003604 ENSPPAP00000004425 ENSPPAP00000004425 SLC25A37 SLC25A37 LTF LTF TFRC TFRC SRI SRI FTMT FTMT ENSPPAP00000005833 ENSPPAP00000005833 ALAS2 ALAS2 EGLN1 EGLN1 SLC22A17 SLC22A17 FTL FTL ABCB6 ABCB6 TF TF SLC39A14 SLC39A14 BMP6 BMP6 CYBRD1 CYBRD1 BOLA1 BOLA1 ENSPPAP00000006569 ENSPPAP00000006569 STEAP1 STEAP1 MYC MYC NDFIP1 NDFIP1 LCN2 LCN2 SOD1 SOD1 ISCU ISCU ENSPPAP00000008676 ENSPPAP00000008676 FTHL17 FTHL17 ENSPPAP00000040620 ENSPPAP00000040620 TMPRSS6 TMPRSS6 NEO1 NEO1 ENSPPAP00000042565 ENSPPAP00000042565 HPX HPX EPB42 EPB42 ENSPPAP00000038923 ENSPPAP00000038923 HFE HFE ATP6V1A ATP6V1A CYB561A3 CYB561A3 HJV HJV HEPHL1 HEPHL1 BOLA2B BOLA2B GLRX3 GLRX3 ATP6V0D1 ATP6V0D1 FXN FXN HAMP HAMP BOLA3 BOLA3 BDH2 BDH2 IREB2 IREB2 FRRS1 FRRS1 EIF2AK1 EIF2AK1 SLC11A2 SLC11A2 ENSPPAP00000030781 ENSPPAP00000030781 BTBD9 BTBD9 ENSPPAP00000030022 ENSPPAP00000030022 SLC25A28 SLC25A28 HEPH HEPH CCDC115 CCDC115 FLVCR1 FLVCR1 ENSPPAP00000028739 ENSPPAP00000028739 ATP6V0A2 ATP6V0A2 ENSPPAP00000026980 ENSPPAP00000026980 EPAS1 EPAS1 ENSPPAP00000026711 ENSPPAP00000026711 ATP6AP1 ATP6AP1 PICALM PICALM HMOX1 HMOX1 SLC39A8 SLC39A8 ATP13A2 ATP13A2 SLC40A1 SLC40A1 TTC7A TTC7A HYAL2 HYAL2 SLC46A1 SLC46A1 LOC100993774 LOC100993774 NUBP1 NUBP1 SLC11A1 SLC11A1 CP CP RHAG RHAG ACO1 ACO1 TFR2 TFR2 STEAP4 STEAP4 SCARA5 SCARA5 LOC100974147 LOC100974147 MELTF MELTF ENSPPAP00000017113 ENSPPAP00000017113 ABCB7 ABCB7 HIF1A HIF1A HMOX2 HMOX2 NCOA4 NCOA4 SMAD4 SMAD4 ENSPPAP00000009349 ENSPPAP00000009349 STEAP3 STEAP3 FTH1 FTH1 ENSPPAP00000000983 ENSPPAP00000000983 ENSPPAP00000001059 ENSPPAP00000001059 FBXL5 FBXL5 ATP6V1G1 ATP6V1G1 LOC100992304 LOC100992304
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPPAP00000002253Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (173 aa)
TMEM199Transmembrane protein 199. (208 aa)
GDF2Growth differentiation factor 2. (429 aa)
STEAP2STEAP2 metalloreductase. (490 aa)
ENSPPAP00000003604Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (113 aa)
ENSPPAP00000004425Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (162 aa)
SLC25A37Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (327 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
TFRCTransferrin receptor. (773 aa)
SRISorcin. (195 aa)
FTMTFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (241 aa)
ENSPPAP00000005833ARA70 domain-containing protein. (499 aa)
ALAS25-aminolevulinate synthase. (611 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (341 aa)
SLC22A17Solute carrier family 22 member 17. (538 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (182 aa)
ABCB6ATP binding cassette subfamily B member 6 (Langereis blood group). (854 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
BMP6Bone morphogenetic protein 6. (453 aa)
CYBRD1Cytochrome b reductase 1. (286 aa)
BOLA1BolA family member 1; Belongs to the BolA/IbaG family. (137 aa)
ENSPPAP00000006569Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (141 aa)
STEAP1STEAP family member 1. (338 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
NDFIP1Nedd4 family interacting protein 1. (200 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (200 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
ISCUIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (167 aa)
ENSPPAP00000008676Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (158 aa)
FTHL17Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
ENSPPAP00000040620Uncharacterized protein; Belongs to the BolA/IbaG family. (96 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (824 aa)
NEO1Neogenin 1. (1444 aa)
ENSPPAP00000042565Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (167 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
EPB42Erythrocyte membrane protein band 4.2. (721 aa)
ENSPPAP00000038923Uncharacterized protein. (200 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (618 aa)
CYB561A3Cytochrome b561 family member A3. (259 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
HEPHL1Hephaestin like 1; Belongs to the multicopper oxidase family. (1159 aa)
BOLA2BUncharacterized protein; Belongs to the BolA/IbaG family. (152 aa)
GLRX3Glutaredoxin 3. (335 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (392 aa)
FXNFrataxin. (210 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
BOLA3BolA family member 3; Belongs to the BolA/IbaG family. (114 aa)
BDH23-hydroxybutyrate dehydrogenase 2. (245 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (963 aa)
FRRS1Ferric chelate reductase 1. (592 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (630 aa)
SLC11A2Solute carrier family 11 member 2. (590 aa)
ENSPPAP00000030781Uncharacterized protein. (88 aa)
BTBD9BTB domain containing 9. (612 aa)
ENSPPAP00000030022Uncharacterized protein. (100 aa)
SLC25A28Solute carrier family 25 member 28; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
HEPHHephaestin; Belongs to the multicopper oxidase family. (1161 aa)
CCDC115Uncharacterized protein. (193 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (569 aa)
ENSPPAP00000028739Uncharacterized protein. (554 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
ENSPPAP00000026980Uncharacterized protein. (293 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
ENSPPAP00000026711Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (161 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (468 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (673 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
SLC39A8Solute carrier family 39 member 8. (444 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1195 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (571 aa)
TTC7ATetratricopeptide repeat domain 7A. (882 aa)
HYAL2Hyaluronidase. (473 aa)
SLC46A1Solute carrier family 46 member 1. (417 aa)
LOC100993774Cytochrome b561 domain-containing protein. (317 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (320 aa)
SLC11A1Solute carrier family 11 member 1. (550 aa)
CPCeruloplasmin; Belongs to the multicopper oxidase family. (1069 aa)
RHAGRh associated glycoprotein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (441 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa)
TFR2Transferrin receptor 2. (675 aa)
STEAP4STEAP4 metalloreductase. (459 aa)
SCARA5Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...] (469 aa)
LOC100974147Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (165 aa)
MELTFMelanotransferrin; Belongs to the transferrin family. (750 aa)
ENSPPAP00000017113V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (77 aa)
ABCB7ATP binding cassette subfamily B member 7. (753 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
HMOX2Heme oxygenase 2. (370 aa)
NCOA4Nuclear receptor coactivator 4. (650 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSPPAP00000009349Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (157 aa)
STEAP3STEAP3 metalloreductase. (498 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (146 aa)
ENSPPAP00000000983Uncharacterized protein; Belongs to the BolA/IbaG family. (75 aa)
ENSPPAP00000001059Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (113 aa)
FBXL5F-box and leucine rich repeat protein 5. (684 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
LOC100992304Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (162 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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