STRINGSTRING
USP45 USP45 ATP2B1 ATP2B1 AGTPBP1 AGTPBP1 LOC100989599 LOC100989599 PAX6 PAX6 SMARCA4 SMARCA4 MEGF11 MEGF11 TFAP2A TFAP2A ATP2B2 ATP2B2 HIPK2 HIPK2 TOPORS TOPORS ACVR2B ACVR2B ENSPPAP00000040590 ENSPPAP00000040590 GPM6A GPM6A RPE65 RPE65 NR2E3 NR2E3 CALB1 CALB1 SLC17A7 SLC17A7 FAT3 FAT3 LPCAT1 LPCAT1 MFRP MFRP SLC17A8 SLC17A8 MAX MAX FJX1 FJX1 TTLL5 TTLL5 RHO RHO ATP2B4 ATP2B4 HCN1 HCN1 IGSF22 IGSF22 RS1 RS1 TBC1D32 TBC1D32 LHX1 LHX1 STAT3 STAT3 MED1 MED1 ENSPPAP00000035037 ENSPPAP00000035037 VSX1 VSX1 CNTF CNTF CLN8 CLN8 BAX BAX FZD4 FZD4 LRP5L LRP5L RPGRIP1L RPGRIP1L NOTCH1 NOTCH1 SMARCD3 SMARCD3 SCAPER SCAPER NR2E1 NR2E1 RD3 RD3 PSEN1 PSEN1 DTNBP1 DTNBP1 FOXN4 FOXN4 ENSPPAP00000030653 ENSPPAP00000030653 PDE6A PDE6A DCLK1 DCLK1 GNB1 GNB1 MFSD2A MFSD2A MAN2A1 MAN2A1 PDE6B PDE6B NTRK2 NTRK2 LOC100975953 LOC100975953 PDGFRB PDGFRB OBSL1 OBSL1 PFDN5 PFDN5 DLL1 DLL1 RP1 RP1 GRM6 GRM6 CRB1 CRB1 IMPG2 IMPG2 GDF11 GDF11 HIPK1 HIPK1 TENT2 TENT2 ACVRL1 ACVRL1 ROM1 ROM1 CLIC4 CLIC4 DCX DCX PROX1 PROX1 POU4F2 POU4F2 PRPH2 PRPH2 RPGRIP1 RPGRIP1 ACHE ACHE TGIF2 TGIF2 ENSPPAP00000022866 ENSPPAP00000022866 LAMB2 LAMB2 SLC4A5 SLC4A5 GNAT1 GNAT1 LHX2 LHX2 BARHL2 BARHL2 LAMC3 LAMC3 ENSPPAP00000021985 ENSPPAP00000021985 IHH IHH RET RET BBS4 BBS4 TSPAN12 TSPAN12 XRN2 XRN2 SDK1 SDK1 CHD7 CHD7 PAX4 PAX4 ARHGEF15 ARHGEF15 PROM1 PROM1 TUB TUB CDON CDON HPCAL1 HPCAL1 CLCN2 CLCN2 AHI1 AHI1 MDM1 MDM1 SERPINF1 SERPINF1 ACTL6A ACTL6A NRL NRL BSG BSG NECTIN1 NECTIN1 NECTIN3 NECTIN3 TFAP2B TFAP2B NPHP1 NPHP1 CABP4 CABP4 TULP1 TULP1 CRB2 CRB2 TGFB2 TGFB2 SKI SKI MERTK MERTK THY1 THY1 TCIRG1 TCIRG1 SDK2 SDK2 ATP8A2 ATP8A2 ENSPPAP00000011900 ENSPPAP00000011900 IMPDH2 IMPDH2 NDP NDP USH1C USH1C RHOJ RHOJ HIF1A HIF1A JMJD6 JMJD6 CASP2 CASP2 HPCA HPCA THRB THRB LRP5 LRP5 SLC1A1 SLC1A1 GNAT2 GNAT2 RORB RORB NAGLU NAGLU VSTM4 VSTM4 PDE6C PDE6C COL4A1 COL4A1 NPHP4 NPHP4 VAX2 VAX2 ZHX2 ZHX2 TTC8 TTC8 BMPR1B BMPR1B PTPRM PTPRM NEUROD4 NEUROD4 RDH13 RDH13 RPL24 RPL24 IGFN1 IGFN1 BMPR2 BMPR2 DSCAM DSCAM RP1L1 RP1L1 PAX2 PAX2 ZNF513 ZNF513 HES1 HES1 NRP1 NRP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (814 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
AGTPBP1ATP/GTP binding protein 1. (1248 aa)
LOC100989599Uncharacterized protein; Belongs to the cytochrome P450 family. (339 aa)
PAX6Uncharacterized protein. (467 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
MEGF11Multiple EGF like domains 11. (990 aa)
TFAP2ATF_AP-2 domain-containing protein. (328 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
HIPK2Protein kinase domain-containing protein. (954 aa)
TOPORSTOP1 binding arginine/serine rich protein. (1044 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
ENSPPAP00000040590Uncharacterized protein. (91 aa)
GPM6AGlycoprotein M6A. (278 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
NR2E3Nuclear receptor subfamily 2 group E member 3. (410 aa)
CALB1Calbindin 1. (261 aa)
SLC17A7Solute carrier family 17 member 7. (560 aa)
FAT3Uncharacterized protein. (892 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1. (489 aa)
MFRPMembrane frizzled-related protein. (579 aa)
SLC17A8Solute carrier family 17 member 8. (589 aa)
MAXMYC associated factor X. (160 aa)
FJX1Uncharacterized protein. (378 aa)
TTLL5Tubulin tyrosine ligase like 5. (1289 aa)
RHORhodopsin. (348 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (883 aa)
IGSF22Immunoglobulin superfamily member 22. (1326 aa)
RS1Retinoschisin 1. (224 aa)
TBC1D32TBC1 domain family member 32. (1298 aa)
LHX1LIM homeobox 1. (406 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1555 aa)
ENSPPAP00000035037TRASH domain-containing protein. (133 aa)
VSX1Visual system homeobox 1. (365 aa)
CNTFCiliary neurotrophic factor. (200 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
LRP5LLDL receptor related protein 5 like. (252 aa)
RPGRIP1LRPGRIP1 like. (1309 aa)
NOTCH1Notch receptor 1. (2573 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (430 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1392 aa)
NR2E1Uncharacterized protein. (385 aa)
RD3Retinal degeneration 3, GUCY2D regulator. (195 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
DTNBP1Dystrobrevin binding protein 1. (351 aa)
FOXN4Forkhead box N4. (512 aa)
ENSPPAP00000030653Uncharacterized protein. (62 aa)
PDE6APhosphodiesterase. (951 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
GNB1G protein subunit beta 1. (340 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (530 aa)
MAN2A1Alpha-mannosidase. (1144 aa)
PDE6BPhosphodiesterase. (805 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
LOC100975953Uncharacterized protein. (678 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
OBSL1Obscurin like 1. (1862 aa)
PFDN5Prefoldin subunit 5. (154 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (624 aa)
RP1RP1 axonemal microtubule associated. (2152 aa)
GRM6Glutamate metabotropic receptor 6. (752 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
IMPG2Interphotoreceptor matrix proteoglycan 2. (1243 aa)
GDF11Growth differentiation factor 11. (398 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
TENT2Terminal nucleotidyltransferase 2. (484 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ROM1Retinal outer segment membrane protein 1. (351 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
DCXDoublecortin. (420 aa)
PROX1Prospero homeobox 1. (737 aa)
POU4F2POU domain protein. (406 aa)
PRPH2Peripherin 2. (346 aa)
RPGRIP1RPGR interacting protein 1. (1239 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (617 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
ENSPPAP00000022866Uncharacterized protein. (127 aa)
LAMB2Laminin subunit beta 2. (1780 aa)
SLC4A5Anion exchange protein. (1091 aa)
GNAT1G protein subunit alpha transducin 1. (350 aa)
LHX2LIM homeobox 2. (406 aa)
BARHL2BarH like homeobox 2. (387 aa)
LAMC3Laminin subunit gamma 3. (1559 aa)
ENSPPAP00000021985Uncharacterized protein. (250 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (402 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
BBS4Bardet-Biedl syndrome 4. (547 aa)
TSPAN12Tetraspanin. (305 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa)
SDK1Sidekick cell adhesion molecule 1. (2113 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
PAX4Paired box 4. (351 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (841 aa)
PROM1Prominin 1. (865 aa)
TUBTubby-like protein; Belongs to the TUB family. (561 aa)
CDONCell adhesion associated, oncogene regulated. (1264 aa)
HPCAL1Hippocalcin like 1. (193 aa)
CLCN2Chloride channel protein. (902 aa)
AHI1Abelson helper integration site 1. (1240 aa)
MDM1Mdm1 nuclear protein. (724 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
ACTL6AActin like 6A; Belongs to the actin family. (430 aa)
NRLNeural retina leucine zipper. (237 aa)
BSGBasigin (Ok blood group). (362 aa)
NECTIN1Nectin cell adhesion molecule 1. (516 aa)
NECTIN3Nectin cell adhesion molecule 3. (504 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
NPHP1Nephrocystin 1. (729 aa)
CABP4Calcium binding protein 4. (275 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (541 aa)
CRB2Crumbs cell polarity complex component 2. (1083 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SKISKI proto-oncogene. (666 aa)
MERTKMER proto-oncogene, tyrosine kinase. (966 aa)
THY1Thy-1 cell surface antigen. (161 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
SDK2Sidekick cell adhesion molecule 2. (2172 aa)
ATP8A2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1162 aa)
ENSPPAP00000011900HMG box domain-containing protein. (291 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
NDPNorrin cystine knot growth factor NDP. (133 aa)
USH1CUSH1 protein network component harmonin. (899 aa)
RHOJRas homolog family member J. (214 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (420 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
HPCAHippocalcin. (193 aa)
THRBUncharacterized protein. (476 aa)
LRP5LDL receptor related protein 5. (1839 aa)
SLC1A1Amino acid transporter. (524 aa)
GNAT2G protein subunit alpha transducin 2. (354 aa)
RORBRAR related orphan receptor B. (482 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (682 aa)
VSTM4V-set and transmembrane domain containing 4. (339 aa)
PDE6CPhosphodiesterase. (858 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
NPHP4Nephrocystin 4. (1426 aa)
VAX2Ventral anterior homeobox 2. (290 aa)
ZHX2Zinc fingers and homeoboxes 2. (837 aa)
TTC8Tetratricopeptide repeat domain 8. (531 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1465 aa)
NEUROD4BHLH domain-containing protein. (255 aa)
RDH13Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
RPL24TRASH domain-containing protein. (157 aa)
IGFN1Uncharacterized protein. (1240 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
DSCAMDS cell adhesion molecule. (1895 aa)
RP1L1Uncharacterized protein. (1911 aa)
PAX2Paired box 2. (417 aa)
ZNF513Zinc finger protein 513. (541 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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