(22 nodes) Uterus development network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASH1L	ASH1 like histone lysine methyltransferase. (2923 aa)
	LHCGR	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
	FSHR	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa)
	STRA6	Stimulated by retinoic acid 6. (706 aa)
	HOXA11	Homeobox A11. (327 aa)
	NIPBL	Nipped-B protein. (2804 aa)
	SRC	Tyrosine-protein kinase. (458 aa)
	LHX1	LIM homeobox 1. (406 aa)
	MYOCD	Myocardin. (986 aa)
	KDM5B	Lysine demethylase 5B. (1580 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1924 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	GATA3	GATA binding protein 3. (444 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ENSPPAP00000009786	Homeobox domain-containing protein. (168 aa)
	HOXA10	Homeobox A10. (398 aa)
	CYP19A1	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
	GREB1	Growth regulating estrogen receptor binding 1. (1926 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASH1L	KDM5B	ENSPPAP00000017744	ENSPPAP00000037489	ASH1 like histone lysine methyltransferase.	Lysine demethylase 5B.	0.505
ASH1L	NIPBL	ENSPPAP00000017744	ENSPPAP00000030541	ASH1 like histone lysine methyltransferase.	Nipped-B protein.	0.702
CYP19A1	ESR1	ENSPPAP00000012728	ENSPPAP00000006837	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.785
CYP19A1	FSHR	ENSPPAP00000012728	ENSPPAP00000018265	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	0.681
CYP19A1	LHCGR	ENSPPAP00000012728	ENSPPAP00000017775	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.676
ENSPPAP00000009786	HOXA10	ENSPPAP00000009786	ENSPPAP00000009984	Homeobox domain-containing protein.	Homeobox A10.	0.552
ESR1	CYP19A1	ENSPPAP00000006837	ENSPPAP00000012728	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.785
ESR1	FSHR	ENSPPAP00000006837	ENSPPAP00000018265	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	0.459
ESR1	GATA3	ENSPPAP00000006837	ENSPPAP00000007588	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	GATA binding protein 3.	0.901
ESR1	GREB1	ENSPPAP00000006837	ENSPPAP00000013865	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Growth regulating estrogen receptor binding 1.	0.914
ESR1	GREB1L	ENSPPAP00000006837	ENSPPAP00000004216	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	GREB1 like retinoic acid receptor coactivator.	0.501
ESR1	KDM5B	ENSPPAP00000006837	ENSPPAP00000037489	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Lysine demethylase 5B.	0.561
ESR1	LHCGR	ENSPPAP00000006837	ENSPPAP00000017775	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.550
ESR1	SMAD4	ENSPPAP00000006837	ENSPPAP00000009478	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mothers against decapentaplegic homolog.	0.668
ESR1	SRC	ENSPPAP00000006837	ENSPPAP00000035810	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Tyrosine-protein kinase.	0.999
FSHR	CYP19A1	ENSPPAP00000018265	ENSPPAP00000012728	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.681
FSHR	ESR1	ENSPPAP00000018265	ENSPPAP00000006837	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.459
FSHR	LHCGR	ENSPPAP00000018265	ENSPPAP00000017775	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.490
GATA3	ESR1	ENSPPAP00000007588	ENSPPAP00000006837	GATA binding protein 3.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.901
GREB1	ESR1	ENSPPAP00000013865	ENSPPAP00000006837	Growth regulating estrogen receptor binding 1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.914