(46 nodes) Long-term synaptic potentiation network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MPP2	Membrane palmitoylated protein 2; Belongs to the MAGUK family. (597 aa)
	PRRT1	Proline rich transmembrane protein 1. (306 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (297 aa)
	RGS14	Regulator of G protein signaling 14. (567 aa)
	SLC8A2	Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (908 aa)
	SNAP47	Synaptosome associated protein 47. (419 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	SYT12	Synaptotagmin 12. (420 aa)
	GIP	Uncharacterized protein. (94 aa)
	PTEN	Uncharacterized protein. (542 aa)
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
	SLC1A1	Amino acid transporter. (524 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	NFATC4	Nuclear factor of activated T cells 4. (963 aa)
	SNCA	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
	MAPK1	Mitogen-activated protein kinase. (339 aa)
	SLC8A3	Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (210 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	SLC24A2	Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (661 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (290 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	LRRTM1	Leucine rich repeat transmembrane neuronal 1. (522 aa)
	ARC	Activity regulated cytoskeleton associated protein. (396 aa)
	RASGRF2	Ras protein specific guanine nucleotide releasing factor 2. (1237 aa)
	SLC24A1	Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1094 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (505 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (409 aa)
	NPTN	Neuroplastin. (390 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2685 aa)
	PLK2	Serine/threonine-protein kinase PLK. (685 aa)
	SHANK2	Uncharacterized protein. (1849 aa)
	LOC100995377	Uncharacterized protein. (557 aa)
	CRHR2	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (438 aa)
	NR2E1	Uncharacterized protein. (385 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	ENSPPAP00000026998	Uncharacterized protein. (493 aa)
	TSHZ3	Teashirt zinc finger homeobox 3. (1081 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (766 aa)
	LOC100989438	Uncharacterized protein. (873 aa)
	RELN	Reelin. (3460 aa)
	TNR	Tenascin R. (1360 aa)
	GRIN2D	Uncharacterized protein. (806 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (493 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARC	GRIN2B	ENSPPAP00000000134	ENSPPAP00000007453	Activity regulated cytoskeleton associated protein.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.622
ARC	NTRK2	ENSPPAP00000000134	ENSPPAP00000029510	Activity regulated cytoskeleton associated protein.	Tyrosine-protein kinase receptor.	0.532
BRAF	LOC100995377	ENSPPAP00000025756	ENSPPAP00000033339	B-Raf proto-oncogene, serine/threonine kinase.	Uncharacterized protein.	0.664
BRAF	MAPK1	ENSPPAP00000025756	ENSPPAP00000006243	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase.	0.843
BRAF	PRKCG	ENSPPAP00000025756	ENSPPAP00000013387	B-Raf proto-oncogene, serine/threonine kinase.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.406
BRAF	PTEN	ENSPPAP00000025756	ENSPPAP00000012238	B-Raf proto-oncogene, serine/threonine kinase.	Uncharacterized protein.	0.664
DRD1	GIP	ENSPPAP00000003622	ENSPPAP00000013129	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.905
DRD1	GRIN2A	ENSPPAP00000003622	ENSPPAP00000022405	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.572
DRD1	GRIN2B	ENSPPAP00000003622	ENSPPAP00000007453	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.471
DRD1	RGS14	ENSPPAP00000003622	ENSPPAP00000019102	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	Regulator of G protein signaling 14.	0.425
ENSPPAP00000026998	MAPK1	ENSPPAP00000026998	ENSPPAP00000006243	Uncharacterized protein.	Mitogen-activated protein kinase.	0.579
GFAP	GRIN2B	ENSPPAP00000039275	ENSPPAP00000007453	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.408
GFAP	NR2E1	ENSPPAP00000039275	ENSPPAP00000032150	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Uncharacterized protein.	0.483
GFAP	NTRK2	ENSPPAP00000039275	ENSPPAP00000029510	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Tyrosine-protein kinase receptor.	0.516
GFAP	SNAP25	ENSPPAP00000039275	ENSPPAP00000009609	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.644
GFAP	SNCA	ENSPPAP00000039275	ENSPPAP00000006465	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	0.527
GIP	DRD1	ENSPPAP00000013129	ENSPPAP00000003622	Uncharacterized protein.	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	0.905
GRIN2A	DRD1	ENSPPAP00000022405	ENSPPAP00000003622	Glutamate ionotropic receptor NMDA type subunit 2A.	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	0.572
GRIN2A	GRIN2B	ENSPPAP00000022405	ENSPPAP00000007453	Glutamate ionotropic receptor NMDA type subunit 2A.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.999
GRIN2A	GRIN2D	ENSPPAP00000022405	ENSPPAP00000022859	Glutamate ionotropic receptor NMDA type subunit 2A.	Uncharacterized protein.	0.966