STRINGSTRING
HES1 HES1 FGF9 FGF9 SPRY1 SPRY1 MMP12 MMP12 CRISPLD2 CRISPLD2 NOG NOG NKX2-1 NKX2-1 ENSPPAP00000001955 ENSPPAP00000001955 LTA4H LTA4H WNT11 WNT11 PDGFA PDGFA PHEX PHEX LIF LIF PTGES3 PTGES3 GATA6 GATA6 ZFPM2 ZFPM2 CEBPA CEBPA FNDC3B FNDC3B BMPR2 BMPR2 DISP1 DISP1 NKIRAS2 NKIRAS2 LOXL3 LOXL3 MME MME CRH CRH EXT1 EXT1 HS6ST1 HS6ST1 PPP1CA PPP1CA MAPK1 MAPK1 DNAAF1 DNAAF1 ADA ADA IGFBP5 IGFBP5 ADAMTS2 ADAMTS2 ABCA12 ABCA12 WNT5A WNT5A SAV1 SAV1 CCDC39 CCDC39 CCDC40 CCDC40 HESX1 HESX1 TAB1 TAB1 CYP1A2 CYP1A2 ASXL1 ASXL1 PGR PGR SP3 SP3 ENSPPAP00000010419 ENSPPAP00000010419 THRB THRB FBXW9 FBXW9 ESRP2 ESRP2 SRF SRF JMJD6 JMJD6 BMP4 BMP4 RAB3A RAB3A MAN1A2 MAN1A2 ADAMTSL2 ADAMTSL2 RARG RARG MAP2K2 MAP2K2 RSPO2 RSPO2 TBX5 TBX5 BAG6 BAG6 TULP3 TULP3 HOPX HOPX RIDA RIDA ZIC3 ZIC3 LOC100982721 LOC100982721 NFIB NFIB HSPB11 HSPB11 ABCA3 ABCA3 SIX4 SIX4 WNT2 WNT2 NUMA1 NUMA1 SKI SKI TBX2 TBX2 DPPA4 DPPA4 LAMA5 LAMA5 DLX5 DLX5 CCBE1 CCBE1 ARG1 ARG1 TGFB1 TGFB1 COL3A1 COL3A1 TGFB3 TGFB3 LHX3 LHX3 SELENON SELENON CLCN2 CLCN2 NODAL NODAL EP300 EP300 HHIP HHIP WDPCP WDPCP SIM2 SIM2 CHD7 CHD7 HMGCS2 HMGCS2 CHI3L1 CHI3L1 TMEM38B TMEM38B SHH SHH FGFRL1 FGFRL1 SREBF1 SREBF1 ALDH1A2 ALDH1A2 WT1 WT1 ITGA3 ITGA3 ERRFI1 ERRFI1 TTC25 TTC25 FGFR2 FGFR2 NKIRAS1 NKIRAS1 FBXW7 FBXW7 ASS1 ASS1 AIMP2 AIMP2 PROX1 PROX1 TIMELESS TIMELESS SPRY2 SPRY2 SMAD2 SMAD2 CTNNB1 CTNNB1 FOXF1 FOXF1 LOX LOX DAG1 DAG1 ENSPPAP00000025509 ENSPPAP00000025509 STRA6 STRA6 MSC MSC RC3H2 RC3H2 ASCL1 ASCL1 EPAS1 EPAS1 WNT7B WNT7B ENSPPAP00000026779 ENSPPAP00000026779 LTBP3 LTBP3 ENSPPAP00000026880 ENSPPAP00000026880 FOXJ1 FOXJ1 CCN2 CCN2 GLI2 GLI2 RCN3 RCN3 EDA EDA FGF7 FGF7 MMP14 MMP14 SPEF2 SPEF2 LIPA LIPA PHOX2B PHOX2B SMCHD1 SMCHD1 AGR2 AGR2 HIKESHI HIKESHI PDGFRB PDGFRB CELSR1 CELSR1 ENSPPAP00000029448 ENSPPAP00000029448 THRA THRA SEC24B SEC24B MAN2A1 MAN2A1 STK40 STK40 HYDIN HYDIN MAPK3 MAPK3 ENSPPAP00000030737 ENSPPAP00000030737 PLOD3 PLOD3 KRAS KRAS NKX2-8 NKX2-8 RBBP9 RBBP9 YWHAZ YWHAZ AP3B1 AP3B1 TBX4 TBX4 EDN2 EDN2 ENSPPAP00000032433 ENSPPAP00000032433 NOS3 NOS3 PDPN PDPN FGF10 FGF10 SMPD3 SMPD3 SLC7A11 SLC7A11 PTK7 PTK7 NOTCH1 NOTCH1 RPGRIP1L RPGRIP1L BMPR1A BMPR1A FGF8 FGF8 SFTPD SFTPD FGF1 FGF1 MYOCD MYOCD ENSPPAP00000036285 ENSPPAP00000036285 CTSH CTSH HEG1 HEG1 ITGB6 ITGB6 PHF14 PHF14 LOC100992102 LOC100992102 RDH10 RDH10 DLG5 DLG5 FGF2 FGF2 ATP7A ATP7A RBPJ RBPJ PKDCC PKDCC FLT4 FLT4 ALDH1A3 ALDH1A3 LOC100981710 LOC100981710 RXFP1 RXFP1 SPDEF SPDEF GRHL2 GRHL2 KDR KDR EIF4G1 EIF4G1 CREB1 CREB1 LEF1 LEF1 YAP1 YAP1 GLI3 GLI3 ELK1 ELK1 ACVR2B ACVR2B GLI1 GLI1 HSD11B1 HSD11B1 TCF21 TCF21 SLC23A1 SLC23A1 AARD AARD CTSZ CTSZ EIF4E EIF4E TGFBR2 TGFBR2 ENSPPAP00000042325 ENSPPAP00000042325 FGF18 FGF18 RARA RARA HOXA5 HOXA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HES1Hes family bHLH transcription factor 1. (280 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2. (497 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NKX2-1Uncharacterized protein. (126 aa)
ENSPPAP00000001955Uncharacterized protein. (170 aa)
LTA4HLeukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (607 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
PTGES3Prostaglandin E synthase 3. (164 aa)
GATA6Uncharacterized protein. (402 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1164 aa)
CEBPABZIP domain-containing protein. (141 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
DISP1Dispatched RND transporter family member 1. (1525 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (229 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
MMEMembrane metalloendopeptidase. (750 aa)
CRHCorticotropin releasing hormone. (196 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (279 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (334 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
DNAAF1Dynein assembly factor 1, axonemal. (616 aa)
ADAAdenosine deaminase. (412 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2. (1194 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
CCDC39Coiled-coil domain containing 39. (941 aa)
CCDC40Coiled-coil domain containing 40. (1142 aa)
HESX1Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). (185 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (517 aa)
ASXL1ASXL transcriptional regulator 1. (1536 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (636 aa)
SP3Sp3 transcription factor. (721 aa)
ENSPPAP00000010419Uncharacterized protein. (355 aa)
THRBUncharacterized protein. (476 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
ESRP2Epithelial splicing regulatory protein 2. (713 aa)
SRFSerum response factor. (414 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (420 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
ADAMTSL2ADAMTS like 2. (1064 aa)
RARGRetinoic acid receptor gamma. (464 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
RSPO2R-spondin 2. (243 aa)
TBX5T-box transcription factor 5. (518 aa)
BAG6BCL2 associated athanogene 6. (1162 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (501 aa)
HOPXHOP homeobox. (109 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
ZIC3Zic family member 3. (466 aa)
LOC100982721Uncharacterized protein. (245 aa)
NFIBCTF/NF-I domain-containing protein. (202 aa)
HSPB11Uncharacterized protein. (214 aa)
ABCA3ATP binding cassette subfamily A member 3. (1704 aa)
SIX4SIX homeobox 4. (775 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2115 aa)
SKISKI proto-oncogene. (666 aa)
TBX2T-box transcription factor 2. (622 aa)
DPPA4Developmental pluripotency associated 4. (303 aa)
LAMA5Laminin subunit alpha 5. (3648 aa)
DLX5Distal-less homeobox 5. (289 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
ARG1Arginase. (322 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
COL3A1Collagen type III alpha 1 chain. (1465 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LHX3LIM homeobox 3. (406 aa)
SELENONSelenoprotein N. (495 aa)
CLCN2Chloride channel protein. (902 aa)
NODALNodal growth differentiation factor. (347 aa)
EP300E1A binding protein p300. (2411 aa)
HHIPHedgehog interacting protein. (700 aa)
WDPCPWD repeat containing planar cell polarity effector. (746 aa)
SIM2Uncharacterized protein. (630 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (389 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
FGFRL1Fibroblast growth factor receptor like 1. (507 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
WT1Uncharacterized protein. (429 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
TTC25Tetratricopeptide repeat domain 25. (671 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
AIMP2Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (320 aa)
PROX1Prospero homeobox 1. (737 aa)
TIMELESSTimeless circadian regulator. (1208 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CTNNB1Catenin beta 1. (781 aa)
FOXF1Forkhead box F1. (321 aa)
LOXLysyl oxidase. (417 aa)
DAG1Dystroglycan 1. (895 aa)
ENSPPAP0000002550914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (234 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
MSCBHLH domain-containing protein. (295 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
ENSPPAP00000026779Uncharacterized protein. (720 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1270 aa)
ENSPPAP00000026880Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (222 aa)
FOXJ1Forkhead box J1. (405 aa)
CCN2Cellular communication network factor 2. (334 aa)
GLI2GLI family zinc finger 2. (1587 aa)
RCN3Reticulocalbin 3. (270 aa)
EDATNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (223 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
SPEF2Calponin-homology (CH) domain-containing protein. (2132 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
PHOX2BPaired like homeobox 2B. (282 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2005 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (189 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2933 aa)
ENSPPAP00000029448Uncharacterized protein. (397 aa)
THRAUncharacterized protein. (617 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1236 aa)
MAN2A1Alpha-mannosidase. (1144 aa)
STK40Serine/threonine kinase 40. (435 aa)
HYDINHYDIN axonemal central pair apparatus protein. (4742 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (311 aa)
ENSPPAP00000030737Uncharacterized protein. (408 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (738 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NKX2-8NK2 homeobox 8. (240 aa)
RBBP9RB binding protein 9, serine hydrolase. (186 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
TBX4T-box transcription factor 4. (545 aa)
EDN2Endothelin 2. (178 aa)
ENSPPAP00000032433Uncharacterized protein. (64 aa)
NOS3Nitric oxide synthase 3. (997 aa)
PDPNPodoplanin. (237 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (638 aa)
SLC7A11Solute carrier family 7 member 11. (515 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
NOTCH1Notch receptor 1. (2573 aa)
RPGRIP1LRPGRIP1 like. (1309 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
SFTPDSurfactant protein D. (375 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MYOCDMyocardin. (986 aa)
ENSPPAP00000036285Uncharacterized protein. (393 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
HEG1Heart development protein with EGF like domains 1. (1275 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
PHF14PHD finger protein 14. (944 aa)
LOC100992102CS domain-containing protein. (137 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1809 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (260 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
PKDCCProtein kinase domain-containing protein. (475 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1321 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
LOC100981710Uncharacterized protein. (389 aa)
RXFP1Relaxin family peptide receptor 1. (779 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
GRHL2Grainyhead like transcription factor 2. (618 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1606 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
YAP1Yes associated protein 1. (512 aa)
GLI3GLI family zinc finger 3. (1580 aa)
ELK1ETS transcription factor ELK1. (428 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
GLI1GLI family zinc finger 1. (1106 aa)
HSD11B1Hydroxysteroid 11-beta dehydrogenase 1. (292 aa)
TCF21Transcription factor 21. (179 aa)
SLC23A1Solute carrier family 23 member 1. (598 aa)
AARDUncharacterized protein. (176 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
EIF4EUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
ENSPPAP00000042325Uncharacterized protein. (404 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
RARAUncharacterized protein. (609 aa)
HOXA5Homeobox A5. (270 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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