STRINGSTRING
SPI1 SPI1 PPP2R1B PPP2R1B HAND2 HAND2 FZD5 FZD5 BAX BAX VDR VDR NOTCH1 NOTCH1 NKX2-5 NKX2-5 BMP7 BMP7 CCN1 CCN1 LRRC1 LRRC1 ENSPPAP00000007855 ENSPPAP00000007855 LRP5 LRP5 SCRIB SCRIB BAK1 BAK1 JAG2 JAG2 LEF1 LEF1 CRYAB CRYAB BCL2L11 BCL2L11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPI1Spi-1 proto-oncogene. (271 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (660 aa)
HAND2Uncharacterized protein. (66 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
VDRVitamin D receptor. (477 aa)
NOTCH1Notch receptor 1. (2573 aa)
NKX2-5NK2 homeobox 5. (325 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CCN1Cellular communication network factor 1. (381 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
ENSPPAP00000007855Uncharacterized protein. (192 aa)
LRP5LDL receptor related protein 5. (1839 aa)
SCRIBScribble planar cell polarity protein. (1656 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1099 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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