STRINGSTRING
PSAP PSAP NOTCH1 NOTCH1 WDR77 WDR77 AR AR TP63 TP63 CTNNB1 CTNNB1 FGFR2 FGFR2 FEM1B FEM1B HOXB13 HOXB13 PSAPL1 PSAPL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (534 aa)
NOTCH1Notch receptor 1. (2573 aa)
WDR77WD repeat domain 77. (352 aa)
ARAndrogen receptor. (882 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CTNNB1Catenin beta 1. (781 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
FEM1BFem-1 homolog B. (627 aa)
HOXB13Homeobox B13. (284 aa)
PSAPL1Uncharacterized protein. (253 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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