STRINGSTRING
LSM14A LSM14A TRAF2 TRAF2 TRIM44 TRIM44 CD300LF CD300LF LRRC70 LRRC70 TRIM56 TRIM56 MMP12 MMP12 IL7 IL7 USP27X USP27X TBK1 TBK1 TRIM32 TRIM32 TLR2 TLR2 MAVS MAVS WNT5A WNT5A RIPK1 RIPK1 PAFAH1B1 PAFAH1B1 HIF1A HIF1A EDN1 EDN1 IRF7 IRF7 CASP1 CASP1 DHX9 DHX9 NLRP6 NLRP6 IRGM IRGM TRIM41 TRIM41 GAS6 GAS6 LAPTM5 LAPTM5 TLR4 TLR4 STING1 STING1 ENSPPAP00000019077 ENSPPAP00000019077 UBE2K UBE2K PRKN PRKN FADD FADD NLRC5 NLRC5 IRF3 IRF3 CD74 CD74 TSLP TSLP TXK TXK AXL AXL ENSPPAP00000029844 ENSPPAP00000029844 ZBP1 ZBP1 ADAM17 ADAM17 IFIH1 IFIH1 IKBKE IKBKE IL1R1 IL1R1 AGPAT1 AGPAT1 AGPAT2 AGPAT2 PARP14 PARP14 LOC100972230 LOC100972230 MED1 MED1 TREM2 TREM2 CSF1 CSF1 PARP9 PARP9 RIPK2 RIPK2 C1QTNF4 C1QTNF4 CXCR4 CXCR4 RNF185 RNF185 DDX58 DDX58 GFI1 GFI1 ENSPPAP00000039065 ENSPPAP00000039065 HPX HPX CASP4 CASP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LSM14AUncharacterized protein. (477 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
TRIM44Tripartite motif containing 44. (344 aa)
CD300LFCD300 molecule like family member f. (305 aa)
LRRC70Uncharacterized protein. (71 aa)
TRIM56Tripartite motif containing 56. (755 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
IL7Interleukin 7. (179 aa)
USP27XUbiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa)
TBK1TANK binding kinase 1. (729 aa)
TRIM32Tripartite motif containing 32. (653 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
MAVSMitochondrial antiviral signaling protein. (540 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (805 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
EDN1Endothelin 1. (212 aa)
IRF7Interferon regulatory factor 7. (516 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (403 aa)
DHX9DExH-box helicase 9. (1270 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
IRGMImmunity related GTPase M. (195 aa)
TRIM41Tripartite motif containing 41. (632 aa)
GAS6Growth arrest specific 6. (679 aa)
LAPTM5Lysosomal protein transmembrane 5. (262 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
STING1Stimulator of interferon protein. (379 aa)
ENSPPAP00000019077Uncharacterized protein. (54 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (428 aa)
FADDDeath domain-containing protein. (144 aa)
NLRC5NLR family CARD domain containing 5. (1865 aa)
IRF3Interferon regulatory factor 3. (452 aa)
CD74CD74 molecule. (296 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
TXKTyrosine-protein kinase. (527 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
ENSPPAP00000029844Uncharacterized protein. (229 aa)
ZBP1Z-DNA binding protein 1. (429 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
IFIH1Interferon induced with helicase C domain 1. (1025 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
PARP14Poly [ADP-ribose] polymerase. (1801 aa)
LOC100972230Uncharacterized protein. (458 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1555 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (855 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
C1QTNF4C1q domain-containing protein. (100 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (423 aa)
RNF185Ring finger protein 185. (192 aa)
DDX58DExD/H-box helicase 58. (925 aa)
GFI1Growth factor independent 1 transcriptional repressor. (364 aa)
ENSPPAP00000039065Uncharacterized protein. (350 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
CASP4Caspase 4; Belongs to the peptidase C14A family. (321 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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