(16 nodes) Cardiac cell fate commitment network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOX17	SRY-box transcription factor 17. (428 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	VWA5B2	Von Willebrand factor A domain containing 5B2. (1242 aa)
	TBX3	T-box transcription factor 3. (723 aa)
	TBX18	T-box transcription factor 18. (607 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (268 aa)
	NKX2-5	NK2 homeobox 5. (325 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	WT1	Uncharacterized protein. (429 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	VWA5A	Von Willebrand factor A domain containing 5A. (786 aa)
	ACVR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	VWA5B1	Von Willebrand factor A domain containing 5B1. (1215 aa)
	TENM4	Teneurin transmembrane protein 4. (2769 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ISL1	MESP1	ENSPPAP00000021951	ENSPPAP00000014405	ISL LIM homeobox 1.	Mesoderm posterior bHLH transcription factor 1.	0.482
ISL1	NKX2-5	ENSPPAP00000021951	ENSPPAP00000015856	ISL LIM homeobox 1.	NK2 homeobox 5.	0.649
ISL1	TBX18	ENSPPAP00000021951	ENSPPAP00000011172	ISL LIM homeobox 1.	T-box transcription factor 18.	0.547
ISL1	TBX3	ENSPPAP00000021951	ENSPPAP00000010916	ISL LIM homeobox 1.	T-box transcription factor 3.	0.488
ISL1	TBX5	ENSPPAP00000021951	ENSPPAP00000012540	ISL LIM homeobox 1.	T-box transcription factor 5.	0.578
MESP1	ISL1	ENSPPAP00000014405	ENSPPAP00000021951	Mesoderm posterior bHLH transcription factor 1.	ISL LIM homeobox 1.	0.482
MESP1	NKX2-5	ENSPPAP00000014405	ENSPPAP00000015856	Mesoderm posterior bHLH transcription factor 1.	NK2 homeobox 5.	0.578
MESP1	SOX17	ENSPPAP00000014405	ENSPPAP00000000382	Mesoderm posterior bHLH transcription factor 1.	SRY-box transcription factor 17.	0.612
MESP1	TBX5	ENSPPAP00000014405	ENSPPAP00000012540	Mesoderm posterior bHLH transcription factor 1.	T-box transcription factor 5.	0.502
NKX2-5	ISL1	ENSPPAP00000015856	ENSPPAP00000021951	NK2 homeobox 5.	ISL LIM homeobox 1.	0.649
NKX2-5	MESP1	ENSPPAP00000015856	ENSPPAP00000014405	NK2 homeobox 5.	Mesoderm posterior bHLH transcription factor 1.	0.578
NKX2-5	SOX17	ENSPPAP00000015856	ENSPPAP00000000382	NK2 homeobox 5.	SRY-box transcription factor 17.	0.478
NKX2-5	TBX18	ENSPPAP00000015856	ENSPPAP00000011172	NK2 homeobox 5.	T-box transcription factor 18.	0.587
NKX2-5	TBX3	ENSPPAP00000015856	ENSPPAP00000010916	NK2 homeobox 5.	T-box transcription factor 3.	0.709
NKX2-5	TBX5	ENSPPAP00000015856	ENSPPAP00000012540	NK2 homeobox 5.	T-box transcription factor 5.	0.996
SOX17	MESP1	ENSPPAP00000000382	ENSPPAP00000014405	SRY-box transcription factor 17.	Mesoderm posterior bHLH transcription factor 1.	0.612
SOX17	NKX2-5	ENSPPAP00000000382	ENSPPAP00000015856	SRY-box transcription factor 17.	NK2 homeobox 5.	0.478
SOX17	TBX3	ENSPPAP00000000382	ENSPPAP00000010916	SRY-box transcription factor 17.	T-box transcription factor 3.	0.415
SOX17	WNT3A	ENSPPAP00000000382	ENSPPAP00000020568	SRY-box transcription factor 17.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.587
TBX18	ISL1	ENSPPAP00000011172	ENSPPAP00000021951	T-box transcription factor 18.	ISL LIM homeobox 1.	0.547