(10 nodes) Cardiac pacemaker cell differentiation network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAML1	Mastermind like transcriptional coactivator 1. (911 aa)
	SHOX2	Short stature homeobox 2. (355 aa)
	TBX3	T-box transcription factor 3. (723 aa)
	TBX18	T-box transcription factor 18. (607 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (268 aa)
	NKX2-5	NK2 homeobox 5. (325 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ISL1	MESP1	ENSPPAP00000021951	ENSPPAP00000014405	ISL LIM homeobox 1.	Mesoderm posterior bHLH transcription factor 1.	0.482
ISL1	NKX2-5	ENSPPAP00000021951	ENSPPAP00000015856	ISL LIM homeobox 1.	NK2 homeobox 5.	0.649
ISL1	SHOX2	ENSPPAP00000021951	ENSPPAP00000005409	ISL LIM homeobox 1.	Short stature homeobox 2.	0.461
ISL1	TBX18	ENSPPAP00000021951	ENSPPAP00000011172	ISL LIM homeobox 1.	T-box transcription factor 18.	0.547
ISL1	TBX3	ENSPPAP00000021951	ENSPPAP00000010916	ISL LIM homeobox 1.	T-box transcription factor 3.	0.488
ISL1	TBX5	ENSPPAP00000021951	ENSPPAP00000012540	ISL LIM homeobox 1.	T-box transcription factor 5.	0.578
MESP1	ISL1	ENSPPAP00000014405	ENSPPAP00000021951	Mesoderm posterior bHLH transcription factor 1.	ISL LIM homeobox 1.	0.482
MESP1	NKX2-5	ENSPPAP00000014405	ENSPPAP00000015856	Mesoderm posterior bHLH transcription factor 1.	NK2 homeobox 5.	0.578
MESP1	TBX5	ENSPPAP00000014405	ENSPPAP00000012540	Mesoderm posterior bHLH transcription factor 1.	T-box transcription factor 5.	0.502
NKX2-5	ISL1	ENSPPAP00000015856	ENSPPAP00000021951	NK2 homeobox 5.	ISL LIM homeobox 1.	0.649
NKX2-5	MESP1	ENSPPAP00000015856	ENSPPAP00000014405	NK2 homeobox 5.	Mesoderm posterior bHLH transcription factor 1.	0.578
NKX2-5	TBX18	ENSPPAP00000015856	ENSPPAP00000011172	NK2 homeobox 5.	T-box transcription factor 18.	0.587
NKX2-5	TBX3	ENSPPAP00000015856	ENSPPAP00000010916	NK2 homeobox 5.	T-box transcription factor 3.	0.709
NKX2-5	TBX5	ENSPPAP00000015856	ENSPPAP00000012540	NK2 homeobox 5.	T-box transcription factor 5.	0.996
SHOX2	ISL1	ENSPPAP00000005409	ENSPPAP00000021951	Short stature homeobox 2.	ISL LIM homeobox 1.	0.461
SHOX2	TBX18	ENSPPAP00000005409	ENSPPAP00000011172	Short stature homeobox 2.	T-box transcription factor 18.	0.623
SHOX2	TBX3	ENSPPAP00000005409	ENSPPAP00000010916	Short stature homeobox 2.	T-box transcription factor 3.	0.554
SHOX2	TBX5	ENSPPAP00000005409	ENSPPAP00000012540	Short stature homeobox 2.	T-box transcription factor 5.	0.482
TBX18	ISL1	ENSPPAP00000011172	ENSPPAP00000021951	T-box transcription factor 18.	ISL LIM homeobox 1.	0.547
TBX18	NKX2-5	ENSPPAP00000011172	ENSPPAP00000015856	T-box transcription factor 18.	NK2 homeobox 5.	0.587