(20 nodes) Dendritic spine morphogenesis network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100995377	Uncharacterized protein. (557 aa)
	PRMT3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa)
	DIP2A	Disco interacting protein 2 homolog A. (1563 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains 1. (2007 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
	LOC106634746	Uncharacterized protein. (211 aa)
	WASL	WASP like actin nucleation promoting factor. (474 aa)
	ZNF365	Uncharacterized protein. (407 aa)
	EPHB3	EPH receptor B3. (1031 aa)
	CTNND2	Uncharacterized protein. (817 aa)
	HDAC6	Histone deacetylase 6. (1215 aa)
	EPHB2	EPH receptor B2. (1039 aa)
	LOC100993131	Cell division control protein 42 homolog. (191 aa)
	CDC42	Uncharacterized protein. (191 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	PTEN	Uncharacterized protein. (542 aa)
	PAK3	P21 (RAC1) activated kinase 3. (580 aa)
	EPHB1	EPH receptor B1. (984 aa)
	DOCK10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2187 aa)
	ARC	Activity regulated cytoskeleton associated protein. (396 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARC	DLG4	ENSPPAP00000000134	ENSPPAP00000029670	Activity regulated cytoskeleton associated protein.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.691
CDC42	DLG4	ENSPPAP00000015981	ENSPPAP00000029670	Uncharacterized protein.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.567
CDC42	DOCK10	ENSPPAP00000015981	ENSPPAP00000003399	Uncharacterized protein.	Dedicator of cytokinesis 10; Belongs to the DOCK family.	0.929
CDC42	EPHB2	ENSPPAP00000015981	ENSPPAP00000019552	Uncharacterized protein.	EPH receptor B2.	0.617
CDC42	LOC100995377	ENSPPAP00000015981	ENSPPAP00000033339	Uncharacterized protein.	Uncharacterized protein.	0.949
CDC42	PAK3	ENSPPAP00000015981	ENSPPAP00000007623	Uncharacterized protein.	P21 (RAC1) activated kinase 3.	0.893
CDC42	PTEN	ENSPPAP00000015981	ENSPPAP00000012238	Uncharacterized protein.	Uncharacterized protein.	0.515
CDC42	WASL	ENSPPAP00000015981	ENSPPAP00000027723	Uncharacterized protein.	WASP like actin nucleation promoting factor.	0.995
CTNND2	LOC106634746	ENSPPAP00000021373	ENSPPAP00000027813	Uncharacterized protein.	Uncharacterized protein.	0.899
DLG4	ARC	ENSPPAP00000029670	ENSPPAP00000000134	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Activity regulated cytoskeleton associated protein.	0.691
DLG4	CDC42	ENSPPAP00000029670	ENSPPAP00000015981	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Uncharacterized protein.	0.567
DLG4	LOC100993131	ENSPPAP00000029670	ENSPPAP00000017950	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Cell division control protein 42 homolog.	0.567
DLG4	LOC100995377	ENSPPAP00000029670	ENSPPAP00000033339	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Uncharacterized protein.	0.534
DLG4	PTEN	ENSPPAP00000029670	ENSPPAP00000012238	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Uncharacterized protein.	0.534
DLG4	SHANK1	ENSPPAP00000029670	ENSPPAP00000031370	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	SH3 and multiple ankyrin repeat domains 1.	0.915
DOCK10	CDC42	ENSPPAP00000003399	ENSPPAP00000015981	Dedicator of cytokinesis 10; Belongs to the DOCK family.	Uncharacterized protein.	0.929
DOCK10	LOC100993131	ENSPPAP00000003399	ENSPPAP00000017950	Dedicator of cytokinesis 10; Belongs to the DOCK family.	Cell division control protein 42 homolog.	0.929
EPHB2	CDC42	ENSPPAP00000019552	ENSPPAP00000015981	EPH receptor B2.	Uncharacterized protein.	0.617
EPHB2	EPHB3	ENSPPAP00000019552	ENSPPAP00000022266	EPH receptor B2.	EPH receptor B3.	0.439
EPHB2	LOC100993131	ENSPPAP00000019552	ENSPPAP00000017950	EPH receptor B2.	Cell division control protein 42 homolog.	0.617