STRINGSTRING
ENSPPAP00000027030 ENSPPAP00000027030 ENSPPAP00000043144 ENSPPAP00000043144 SLC9A1 SLC9A1 PDK3 PDK3 ADAM8 ADAM8 HIPK2 HIPK2 CITED2 CITED2 PTGS2 PTGS2 CASP1-2 CASP1-2 CLCA1 CLCA1 PDK1 PDK1 STC2 STC2 AQP3 AQP3 RPTOR RPTOR PTGIS PTGIS RBPJ RBPJ ATP7A ATP7A OPRD1 OPRD1 NPEPPS NPEPPS ENDOG ENDOG TREM2 TREM2 MT3 MT3 SRC SRC SDHD SDHD KCNK3 KCNK3 SCN2A SCN2A UBQLN1 UBQLN1 MGARP MGARP IRAK1 IRAK1 HP1BP3 HP1BP3 BBC3 BBC3 PGK1 PGK1 NOTCH1 NOTCH1 CCNA2 CCNA2 LOC100995377 LOC100995377 RTN4 RTN4 ACAA2 ACAA2 KCNMB1 KCNMB1 PPARD PPARD RORA RORA AK4 AK4 LMNA LMNA DNMT3A DNMT3A NFE2L2 NFE2L2 PHB2 PHB2 PLK3 PLK3 BRIP1 BRIP1 BNIP3L BNIP3L EPAS1 EPAS1 MTOR MTOR CASR CASR HMOX1 HMOX1 SIRT2 SIRT2 LOC100976996 LOC100976996 PRKAA1 PRKAA1 HIF1AN HIF1AN ERO1A ERO1A VHL VHL P4HB P4HB FABP1 FABP1 STOX1 STOX1 KCND2 KCND2 RGCC RGCC SFRP1 SFRP1 AQP1 AQP1 SLC29A1 SLC29A1 EGLN2 EGLN2 MLST8 MLST8 NOP53 NOP53 PRKCE PRKCE LOC100971459 LOC100971459 BMP7 BMP7 TBL2 TBL2 ENSPPAP00000017962 ENSPPAP00000017962 BCL2 BCL2 SUV39H2 SUV39H2 DDR2 DDR2 KCNK2 KCNK2 MDM4 MDM4 PINK1 PINK1 EGLN1 EGLN1 EDN1 EDN1 SUV39H1 SUV39H1 EGR1 EGR1 FMN2 FMN2 TERT TERT STC1 STC1 ENSPPAP00000012297 ENSPPAP00000012297 PTEN PTEN ENSPPAP00000011835 ENSPPAP00000011835 TIGAR TIGAR FAM162A FAM162A PPARG PPARG BNIP3 BNIP3 FNDC1 FNDC1 BACH1 BACH1 TP53 TP53 HIF1A HIF1A CYBB CYBB STUB1 STUB1 ANGPT4 ANGPT4 ATF2 ATF2 GNGT1 GNGT1 ZFP36L1 ZFP36L1 NKX3-1 NKX3-1 SIRT4 SIRT4 CFLAR CFLAR SIRT1 SIRT1 MYC MYC E2F1 E2F1 NDRG1 NDRG1 HILPDA HILPDA FOS FOS NDNF NDNF SLC8A3 SLC8A3 FAM167A FAM167A EGLN3 EGLN3 UCN3 UCN3 GATA6 GATA6 MPL MPL CPEB2 CPEB2 HYOU1 HYOU1 CPEB1 CPEB1 SLC2A4 SLC2A4 VASN VASN LOC100994493 LOC100994493 SLC8A1 SLC8A1 BAD BAD
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPPAP00000027030DEP domain-containing protein. (1105 aa)
ENSPPAP00000043144ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (141 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
PDK3Protein-serine/threonine kinase. (417 aa)
ADAM8ADAM metallopeptidase domain 8. (816 aa)
HIPK2Protein kinase domain-containing protein. (954 aa)
CITED2Uncharacterized protein. (179 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CASP1-2CARD domain-containing protein. (95 aa)
CLCA1Chloride channel accessory 1. (935 aa)
PDK1Protein-serine/threonine kinase. (456 aa)
STC2Stanniocalcin 2. (302 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (501 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
NPEPPSERAP1_C domain-containing protein. (461 aa)
ENDOGEndonuclease. (188 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
MT3Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
SRCTyrosine-protein kinase. (458 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
KCNK3Potassium channel subfamily K member. (378 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
UBQLN1Ubiquilin 1. (589 aa)
MGARPMitochondria localized glutamic acid rich protein. (240 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
HP1BP3Heterochromatin protein 1 binding protein 3. (553 aa)
BBC3Uncharacterized protein. (131 aa)
PGK1Phosphoglycerate kinase. (400 aa)
NOTCH1Notch receptor 1. (2573 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
LOC100995377Uncharacterized protein. (557 aa)
RTN4Reticulon. (604 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
RORARAR related orphan receptor A. (559 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
PHB2Prohibitin. (299 aa)
PLK3Serine/threonine-protein kinase PLK. (673 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1249 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CASRCalcium sensing receptor. (1078 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
LOC100976996Phosphoglycerate kinase. (408 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (349 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
P4HBProtein disulfide-isomerase. (513 aa)
FABP1Fatty acid binding protein 1. (127 aa)
STOX1Storkhead box 1. (885 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
RGCCRegulator of cell cycle. (137 aa)
SFRP1NTR domain-containing protein. (178 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (498 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (407 aa)
MLST8MTOR associated protein, LST8 homolog. (327 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (427 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LOC100971459Phosphoglycerate kinase. (417 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TBL2Transducin beta like 2. (447 aa)
ENSPPAP00000017962ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (172 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
PINK1PTEN induced kinase 1. (554 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (341 aa)
EDN1Endothelin 1. (212 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
FMN2Uncharacterized protein. (42 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1040 aa)
STC1Stanniocalcin 1. (247 aa)
ENSPPAP00000012297Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (453 aa)
PTENUncharacterized protein. (542 aa)
ENSPPAP00000011835Uncharacterized protein. (435 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
FAM162AFamily with sequence similarity 162 member A. (149 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
BNIP3BCL2 interacting protein 3. (252 aa)
FNDC1Fibronectin type III domain containing 1. (1891 aa)
BACH1BTB domain and CNC homolog 1. (736 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
ANGPT4Angiopoietin 4. (503 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
NKX3-1NK3 homeobox 1. (223 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (316 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
SIRT1Sirtuin 1. (693 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
E2F1E2F transcription factor 1. (397 aa)
NDRG1N-myc downstream regulated 1. (394 aa)
HILPDAHypoxia inducible lipid droplet associated. (63 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NDNFNeuron derived neurotrophic factor. (568 aa)
SLC8A3Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (210 aa)
FAM167AFamily with sequence similarity 167 member A. (214 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
UCN3Urocortin 3. (161 aa)
GATA6Uncharacterized protein. (402 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (646 aa)
CPEB2Uncharacterized protein. (547 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
CPEB1Cytoplasmic polyadenylation element binding protein 1. (626 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
VASNVasorin. (673 aa)
LOC100994493Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (476 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
BADBCL2 associated agonist of cell death. (168 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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