(13 nodes) Metanephric mesenchyme development network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	PAX2	Paired box 2. (417 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	SIX1	SIX homeobox 1. (284 aa)
	STAT1	Signal transducer and activator of transcription. (759 aa)
	TCF21	Transcription factor 21. (179 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (788 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	SIX4	SIX homeobox 4. (775 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
	WT1	Uncharacterized protein. (429 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP7	PAX2	ENSPPAP00000018925	ENSPPAP00000001193	Bone morphogenetic protein 7.	Paired box 2.	0.453
BMP7	SHH	ENSPPAP00000018925	ENSPPAP00000020557	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.640
BMP7	SMAD4	ENSPPAP00000018925	ENSPPAP00000009478	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.697
PAX2	BMP7	ENSPPAP00000001193	ENSPPAP00000018925	Paired box 2.	Bone morphogenetic protein 7.	0.453
PAX2	SHH	ENSPPAP00000001193	ENSPPAP00000020557	Paired box 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.459
PAX2	SIX1	ENSPPAP00000001193	ENSPPAP00000033504	Paired box 2.	SIX homeobox 1.	0.645
PAX2	WNT4	ENSPPAP00000001193	ENSPPAP00000002121	Paired box 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.475
PAX2	WT1	ENSPPAP00000001193	ENSPPAP00000021187	Paired box 2.	Uncharacterized protein.	0.674
PDGFRB	STAT1	ENSPPAP00000029028	ENSPPAP00000033854	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	Signal transducer and activator of transcription.	0.562
SHH	BMP7	ENSPPAP00000020557	ENSPPAP00000018925	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 7.	0.640
SHH	PAX2	ENSPPAP00000020557	ENSPPAP00000001193	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Paired box 2.	0.459
SHH	WNT4	ENSPPAP00000020557	ENSPPAP00000002121	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.402
SIX1	PAX2	ENSPPAP00000033504	ENSPPAP00000001193	SIX homeobox 1.	Paired box 2.	0.645
SIX1	SIX4	ENSPPAP00000033504	ENSPPAP00000014392	SIX homeobox 1.	SIX homeobox 4.	0.456
SIX4	SIX1	ENSPPAP00000014392	ENSPPAP00000033504	SIX homeobox 4.	SIX homeobox 1.	0.456
SMAD4	BMP7	ENSPPAP00000009478	ENSPPAP00000018925	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 7.	0.697
STAT1	PDGFRB	ENSPPAP00000033854	ENSPPAP00000029028	Signal transducer and activator of transcription.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.562
TCF21	WT1	ENSPPAP00000041287	ENSPPAP00000021187	Transcription factor 21.	Uncharacterized protein.	0.511
WNT4	PAX2	ENSPPAP00000002121	ENSPPAP00000001193	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Paired box 2.	0.475
WNT4	SHH	ENSPPAP00000002121	ENSPPAP00000020557	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.402