STRINGSTRING
HEY2 HEY2 EXOC4 EXOC4 ROBO1 ROBO1 FOXF1 FOXF1 ACVRL1 ACVRL1 TAF10 TAF10 ACVR1 ACVR1 DCHS1 DCHS1 NOS3 NOS3 NOTCH1 NOTCH1 BMPR1A BMPR1A FGF8 FGF8 SNAI1 SNAI1 RBPJ RBPJ ROBO2 ROBO2 LEF1 LEF1 TGFBR2 TGFBR2 BMP5 BMP5 APLNR APLNR NOG NOG WNT11 WNT11 SNAI2 SNAI2 HNF1A HNF1A ACTL10 ACTL10 WNT5A WNT5A SMAD4 SMAD4 TBX3 TBX3 CPLANE2 CPLANE2 ACTG2 ACTG2 HEY1 HEY1 HEYL HEYL ACTC1 ACTC1 BMP2 BMP2 MDM4 MDM4 TGFB2 TGFB2 TBX2 TBX2 ENG ENG BMP7 BMP7 OSR1 OSR1 MSX1 MSX1 TBX20 TBX20 GATA5 GATA5 WNT3A WNT3A SMAD3 SMAD3 ACTA1 ACTA1 ISL1 ISL1 SMAD2 SMAD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
EXOC4Exocyst complex component 4. (974 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
FOXF1Forkhead box F1. (321 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
DCHS1Dachsous cadherin-related 1. (3175 aa)
NOS3Nitric oxide synthase 3. (997 aa)
NOTCH1Notch receptor 1. (2573 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
HNF1AHNF1 homeobox A. (662 aa)
ACTL10Actin like 10; Belongs to the actin family. (245 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TBX3T-box transcription factor 3. (723 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
ACTG2Actin gamma 2, smooth muscle. (376 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (327 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TBX2T-box transcription factor 2. (622 aa)
ENGEndoglin. (658 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
MSX1Msh homeobox 1. (249 aa)
TBX20Uncharacterized protein. (379 aa)
GATA5GATA binding protein 5. (396 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
ISL1ISL LIM homeobox 1. (349 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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