STRINGSTRING
EGF EGF COL1A1 COL1A1 FGF9 FGF9 BAMBI BAMBI USP47 USP47 RSPO3 RSPO3 AMER1 AMER1 ARNTL ARNTL GPC3 GPC3 USP8 USP8 VPS35 VPS35 DAAM2 DAAM2 CSNK1D CSNK1D RNF146 RNF146 ZEB2 ZEB2 LOC100968831 LOC100968831 FAM53B FAM53B ENSPPAP00000008364 ENSPPAP00000008364 GPRC5B GPRC5B CSNK1G3 CSNK1G3 TMEM198 TMEM198 FZD9 FZD9 GPC5 GPC5 LGR4 LGR4 ENSPPAP00000011329 ENSPPAP00000011329 XIAP XIAP DAPK3 DAPK3 LGR6 LGR6 RSPO2 RSPO2 ENSPPAP00000012290 ENSPPAP00000012290 TNKS TNKS ILK ILK PPM1N PPM1N SCEL SCEL PRDM15 PRDM15 DLX5 DLX5 TGFB1 TGFB1 TRPM4 TRPM4 NLE1 NLE1 NFKB1 NFKB1 PIN1 PIN1 USP34 USP34 RNF220 RNF220 WLS WLS ENSPPAP00000020305 ENSPPAP00000020305 WNT3A WNT3A SMAD3 SMAD3 SFRP4 SFRP4 LGR5 LGR5 SFRP1 SFRP1 ENSPPAP00000022416 ENSPPAP00000022416 DACT1 DACT1 LOC100975570 LOC100975570 FGFR2 FGFR2 GSKIP GSKIP ENSPPAP00000024044 ENSPPAP00000024044 CTDNEP1 CTDNEP1 WNT10B WNT10B WNK1 WNK1 PPM1A PPM1A HHEX HHEX ENSPPAP00000025987 ENSPPAP00000025987 CSNK1G1 CSNK1G1 CAV1 CAV1 EDA EDA TTC21B TTC21B JRK JRK ENSPPAP00000029955 ENSPPAP00000029955 DKK2 DKK2 LRRK1 LRRK1 TMEM9 TMEM9 CDH3 CDH3 PPP2R3A PPP2R3A FGF10 FGF10 PTK7 PTK7 ATP6AP2 ATP6AP2 RUVBL1 RUVBL1 TNKS2 TNKS2 SRC SRC VCP VCP ENSPPAP00000036211 ENSPPAP00000036211 UBR5 UBR5 LRRK2 LRRK2 JUP JUP CCAR2 CCAR2 WNK2 WNK2 PLEKHA4 PLEKHA4 GID8 GID8 SOX4 SOX4 CAPRIN2 CAPRIN2 ADGRA2 ADGRA2 DDX3X DDX3X RBPJ RBPJ RSPO1 RSPO1 RECK RECK ASPM ASPM TBL1XR1 TBL1XR1 SMURF2 SMURF2 YAP1 YAP1 ENSPPAP00000040749 ENSPPAP00000040749 LYPD6 LYPD6 RPS12 RPS12 SEMA5A SEMA5A ENSPPAP00000041589 ENSPPAP00000041589 PPM1B PPM1B ENSPPAP00000042479 ENSPPAP00000042479 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
RSPO3R-spondin 3. (291 aa)
AMER1APC membrane recruitment protein 1. (1136 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (628 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1118 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1077 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
RNF146Ring finger protein 146. (359 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1253 aa)
LOC100968831Uncharacterized protein. (212 aa)
FAM53BFamily with sequence similarity 53 member B. (422 aa)
ENSPPAP00000008364Peptidyl-prolyl cis-trans isomerase. (155 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (421 aa)
CSNK1G3Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (455 aa)
TMEM198Transmembrane protein 198. (360 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (517 aa)
GPC5Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (572 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (935 aa)
ENSPPAP00000011329FCP1 homology domain-containing protein. (218 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (961 aa)
RSPO2R-spondin 2. (243 aa)
ENSPPAP00000012290Uncharacterized protein. (285 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
ILKIntegrin linked kinase. (533 aa)
PPM1NPP2C_C domain-containing protein. (130 aa)
SCELSciellin. (688 aa)
PRDM15PR/SET domain 15. (1469 aa)
DLX5Distal-less homeobox 5. (289 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1138 aa)
NLE1Notchless homolog 1. (485 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (145 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3536 aa)
RNF220Ring finger protein 220. (566 aa)
WLSWnt ligand secretion mediator. (541 aa)
ENSPPAP00000020305Uncharacterized protein. (256 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SFRP4Secreted frizzled related protein 4. (368 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
SFRP1NTR domain-containing protein. (178 aa)
ENSPPAP00000022416Uncharacterized protein. (68 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (750 aa)
LOC100975570Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
GSKIPGSK3B interacting protein. (147 aa)
ENSPPAP00000024044PPM-type phosphatase domain-containing protein. (75 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNK1WNK lysine deficient protein kinase 1. (2832 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
HHEXHematopoietically expressed homeobox. (255 aa)
ENSPPAP0000002598740S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (129 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (475 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
EDATNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (223 aa)
TTC21BTetratricopeptide repeat domain 21B. (1316 aa)
JRKJrk helix-turn-helix protein. (556 aa)
ENSPPAP0000002995540S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (148 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
LRRK1Leucine rich repeat kinase 1. (2015 aa)
TMEM9Transmembrane protein 9. (183 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (350 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
SRCTyrosine-protein kinase. (458 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
ENSPPAP00000036211Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (920 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2757 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
JUPJunction plakoglobin. (745 aa)
CCAR2Cell cycle and apoptosis regulator 2. (930 aa)
WNK2WNK lysine deficient protein kinase 2. (2240 aa)
PLEKHA4Pleckstrin homology domain containing A4. (779 aa)
GID8GID complex subunit 8 homolog. (228 aa)
SOX4HMG box domain-containing protein. (251 aa)
CAPRIN2Caprin family member 2. (1094 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1306 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
RSPO1R-spondin 1. (267 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (970 aa)
ASPMAbnormal spindle microtubule assembly. (3477 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (545 aa)
SMURF2E3 ubiquitin-protein ligase. (790 aa)
YAP1Yes associated protein 1. (512 aa)
ENSPPAP0000004074940S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (132 aa)
LYPD6LY6/PLAUR domain containing 6. (171 aa)
RPS1240S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (132 aa)
SEMA5ASemaphorin 5A. (1074 aa)
ENSPPAP00000041589DUF4203 domain-containing protein. (106 aa)
PPM1BProtein phosphatase, Mg2+/Mn2+ dependent 1B. (479 aa)
ENSPPAP0000004247940S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (138 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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