(74 nodes) Cellular senescence network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CITED2	Uncharacterized protein. (179 aa)
	ENSPPAP00000042406	Uncharacterized protein. (234 aa)
	TERF2	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (472 aa)
	ENSPPAP00000001242	BHLH domain-containing protein. (117 aa)
	ENSPPAP00000042214	Protein kinase domain-containing protein. (328 aa)
	ENSPPAP00000040884	Uncharacterized protein. (263 aa)
	MAPK10	Mitogen-activated protein kinase. (467 aa)
	NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (247 aa)
	LOC100968388	Uncharacterized protein. (273 aa)
	ENSPPAP00000039265	Uncharacterized protein. (495 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	NPM1	Nucleophosmin 1. (294 aa)
	ENSPPAP00000036860	Uncharacterized protein. (189 aa)
	ENSPPAP00000035595	Uncharacterized protein. (261 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1356 aa)
	LOC100993364	Uncharacterized protein. (106 aa)
	LOC100971311	Uncharacterized protein. (261 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (408 aa)
	PLA2R1	Phospholipase A2 receptor 1. (1466 aa)
	CDKN2A	Uncharacterized protein. (173 aa)
	ENSPPAP00000031014	Protein kinase domain-containing protein. (371 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (664 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1035 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
	CDKN2B	Cyclin dependent kinase inhibitor 2B. (138 aa)
	ENSPPAP00000027667	Uncharacterized protein. (98 aa)
	WRN	WRN RecQ like helicase. (1405 aa)
	SPI1	Spi-1 proto-oncogene. (271 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
	ENSPPAP00000027138	Uncharacterized protein. (279 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	MAPK11	Mitogen-activated protein kinase. (325 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	ULK3	Unc-51 like kinase 3. (483 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	MIF	Macrophage migration inhibitory factor. (115 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (382 aa)
	HMGA1	Uncharacterized protein. (201 aa)
	TBX2	T-box transcription factor 2. (622 aa)
	ENSPPAP00000014996	Uncharacterized protein. (108 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	PML	Uncharacterized protein. (836 aa)
	ECRG4	ECRG4 augurin precursor. (126 aa)
	ENSPPAP00000011287	Uncharacterized protein. (271 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	LOC100978286	Uncharacterized protein. (249 aa)
	TBX3	T-box transcription factor 3. (723 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	SRF	Serum response factor. (414 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
	ENSPPAP00000009428	Uncharacterized protein. (295 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	ENSPPAP00000008914	Uncharacterized protein. (164 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1389 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (490 aa)
	SIRT1	Sirtuin 1. (693 aa)
	ENSPPAP00000005982	Uncharacterized protein. (84 aa)
	NUP62	Nsp1_C domain-containing protein. (419 aa)
	SMC6	Structural maintenance of chromosomes 6. (1088 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (628 aa)
	PRMT6	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
	SMC5	SMC_N domain-containing protein. (1101 aa)
	CALR	Calreticulin. (417 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
	KAT6A	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1985 aa)
	BRCA2	BRCA2 DNA repair associated. (3417 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ATM	ENSPPAP00000026444	ENSPPAP00000009058	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.964
ABL1	CALR	ENSPPAP00000026444	ENSPPAP00000001484	Tyrosine-protein kinase.	Calreticulin.	0.490
ABL1	CDK2	ENSPPAP00000026444	ENSPPAP00000023062	Tyrosine-protein kinase.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.561
ABL1	CDKN1A	ENSPPAP00000026444	ENSPPAP00000029279	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1A.	0.763
ABL1	CDKN1B	ENSPPAP00000026444	ENSPPAP00000013143	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1B.	0.598
ABL1	HRAS	ENSPPAP00000026444	ENSPPAP00000010823	Tyrosine-protein kinase.	HRas proto-oncogene, GTPase.	0.624
ABL1	KAT6A	ENSPPAP00000026444	ENSPPAP00000000855	Tyrosine-protein kinase.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.420
ABL1	MAPK11	ENSPPAP00000026444	ENSPPAP00000025888	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.447
ABL1	MAPK14	ENSPPAP00000026444	ENSPPAP00000038351	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.477
ABL1	PML	ENSPPAP00000026444	ENSPPAP00000013020	Tyrosine-protein kinase.	Uncharacterized protein.	0.400
ABL1	PRKCD	ENSPPAP00000026444	ENSPPAP00000020639	Tyrosine-protein kinase.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.455
ABL1	TP53	ENSPPAP00000026444	ENSPPAP00000011040	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.735
ARNTL	SIRT1	ENSPPAP00000003288	ENSPPAP00000007254	Aryl hydrocarbon receptor nuclear translocator like.	Sirtuin 1.	0.927
ATM	ABL1	ENSPPAP00000009058	ENSPPAP00000026444	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.964
ATM	BRCA2	ENSPPAP00000009058	ENSPPAP00000000836	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA2 DNA repair associated.	0.977
ATM	CDK2	ENSPPAP00000009058	ENSPPAP00000023062	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.934
ATM	CDKN1A	ENSPPAP00000009058	ENSPPAP00000029279	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase inhibitor 1A.	0.680
ATM	CDKN1B	ENSPPAP00000009058	ENSPPAP00000013143	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase inhibitor 1B.	0.537
ATM	CDKN2B	ENSPPAP00000009058	ENSPPAP00000028007	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase inhibitor 2B.	0.457
ATM	HRAS	ENSPPAP00000009058	ENSPPAP00000010823	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	HRas proto-oncogene, GTPase.	0.483