STRINGSTRING
ADPRHL2 ADPRHL2 CYREN CYREN RAD51 RAD51 WRAP53 WRAP53 KAT7 KAT7 ZBTB7A ZBTB7A PARP1 PARP1 PARP3 PARP3 ACTR3 ACTR3 VCP VCP SLF2 SLF2 ENSPPAP00000035310 ENSPPAP00000035310 CBX3 CBX3 XRCC4 XRCC4 UBQLN4 UBQLN4 TP53BP1 TP53BP1 SETMAR SETMAR RPA1 RPA1 ENSPPAP00000033492 ENSPPAP00000033492 ENSPPAP00000033156 ENSPPAP00000033156 SLFN11 SLFN11 ENSPPAP00000031824 ENSPPAP00000031824 ARPC5 ARPC5 SAMHD1 SAMHD1 ENSPPAP00000026193 ENSPPAP00000026193 OARD1 OARD1 SLF1 SLF1 INIP INIP XPC XPC PARP9 PARP9 UFL1 UFL1 HROB HROB NHEJ1 NHEJ1 SMARCAL1 SMARCAL1 EXD2 EXD2 ENSPPAP00000038467 ENSPPAP00000038467 POLH POLH HPF1 HPF1 ENSPPAP00000000179 ENSPPAP00000000179 NABP2 NABP2 CGAS CGAS TP53 TP53 ARPC3 ARPC3 ENSPPAP00000013353 ENSPPAP00000013353 WDR70 WDR70 RAD18 RAD18 SMARCAD1 SMARCAD1 SIRT7 SIRT7 MAD2L2 MAD2L2 DDB1 DDB1 TIMELESS TIMELESS PARP2 PARP2 MRE11 MRE11 PHF1 PHF1 INTS3 INTS3 CUL5 CUL5 TONSL TONSL SIRT6 SIRT6 ENSPPAP00000022317 ENSPPAP00000022317 CNTD1 CNTD1 APLF APLF FH FH PRPF19 PRPF19 CBX1 CBX1 ACTR2 ACTR2 FAM178B FAM178B ARPC4 ARPC4 ENSPPAP00000016638 ENSPPAP00000016638 DDB2 DDB2 ENSPPAP00000000657 ENSPPAP00000000657 SHLD1 SHLD1 ENSPPAP00000000925 ENSPPAP00000000925 REC114 REC114 HELQ HELQ ELOA ELOA ERCC6 ERCC6 SMC5 SMC5 ENSPPAP00000002650 ENSPPAP00000002650 PNKP PNKP SMC6 SMC6 NABP1 NABP1 NBN NBN ENSPPAP00000004842 ENSPPAP00000004842 RNF169 RNF169 HELB HELB HUS1B HUS1B RIF1 RIF1 WDR76 WDR76 RBBP8 RBBP8 ENSPPAP00000006492 ENSPPAP00000006492 LOC100979343 LOC100979343 MMS22L MMS22L NKX3-1 NKX3-1 TCEB3CL2 TCEB3CL2 ATF2 ATF2 CBX5 CBX5 RFWD3 RFWD3 SMARCA5 SMARCA5 LMNA LMNA ESCO2 ESCO2 RPA3 RPA3 SMCHD1 SMCHD1 IFFO1 IFFO1 POLL POLL TRAIP TRAIP ARPC2 ARPC2 ENSPPAP00000026353 ENSPPAP00000026353 ENSPPAP00000016751 ENSPPAP00000016751 RNF168 RNF168 AUNIP AUNIP ARPC1A ARPC1A WAS WAS XRCC5 XRCC5 RNF8 RNF8 HUS1 HUS1 PAXX PAXX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADPRHL2ADP-ribosylhydrolase like 2. (364 aa)
CYRENUncharacterized protein. (102 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
WRAP53WD repeat containing antisense to TP53. (533 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
ZBTB7AUncharacterized protein. (509 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1173 aa)
ENSPPAP00000035310Uncharacterized protein. (121 aa)
CBX3Uncharacterized protein. (183 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
UBQLN4Ubiquilin 4. (601 aa)
TP53BP1Tumor protein p53 binding protein 1. (1977 aa)
SETMARSET domain and mariner transposase fusion gene. (684 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
ENSPPAP00000033492Chromo domain-containing protein. (217 aa)
ENSPPAP00000033156Uncharacterized protein; Belongs to the actin family. (338 aa)
SLFN11Schlafen family member 11. (888 aa)
ENSPPAP00000031824Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (341 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
SAMHD1SAM domain and HD domain-containing protein 1. (626 aa)
ENSPPAP00000026193Uncharacterized protein; Belongs to the actin family. (249 aa)
OARD1O-acyl-ADP-ribose deacylase 1. (152 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1058 aa)
INIPINTS3 and NABP interacting protein. (104 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (946 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (855 aa)
UFL1UFM1 specific ligase 1. (778 aa)
HROBChromosome 17 open reading frame 53. (634 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (954 aa)
EXD2Exonuclease 3'-5' domain containing 2. (621 aa)
ENSPPAP00000038467FAM35_C domain-containing protein. (224 aa)
POLHDNA polymerase eta. (712 aa)
HPF1Histone PARylation factor 1. (346 aa)
ENSPPAP00000000179Uncharacterized protein. (77 aa)
NABP2Nucleic acid binding protein 2. (211 aa)
CGASCyclic GMP-AMP synthase. (509 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (158 aa)
ENSPPAP00000013353Uncharacterized protein. (117 aa)
WDR70WD_REPEATS_REGION domain-containing protein. (517 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (495 aa)
SMARCAD1Uncharacterized protein. (1026 aa)
SIRT7Sirtuin 7. (353 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
TIMELESSTimeless circadian regulator. (1208 aa)
PARP2Poly [ADP-ribose] polymerase. (565 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa)
PHF1PHD finger protein 1. (567 aa)
INTS3Integrator complex subunit 3. (1042 aa)
CUL5Cullin 5; Belongs to the cullin family. (775 aa)
TONSLTonsoku like, DNA repair protein. (1383 aa)
SIRT6Sirtuin 6. (355 aa)
ENSPPAP00000022317Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (168 aa)
CNTD1Cyclin N-terminal domain containing 1. (326 aa)
APLFAprataxin and PNKP like factor. (511 aa)
FHFumarate hydratase. (510 aa)
PRPF19Pre-mRNA processing factor 19. (509 aa)
CBX1Uncharacterized protein. (268 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
FAM178BFamily with sequence similarity 178 member B. (649 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (173 aa)
ENSPPAP00000016638Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (612 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
ENSPPAP00000000657Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (168 aa)
SHLD1Shieldin complex subunit 1. (205 aa)
ENSPPAP00000000925Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (187 aa)
REC114REC114 meiotic recombination protein. (265 aa)
HELQHelicase, POLQ like. (1101 aa)
ELOAElongin A. (798 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1491 aa)
SMC5SMC_N domain-containing protein. (1101 aa)
ENSPPAP00000002650Uncharacterized protein. (177 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
SMC6Structural maintenance of chromosomes 6. (1088 aa)
NABP1Nucleic acid binding protein 1. (204 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
ENSPPAP00000004842Chromo domain-containing protein. (101 aa)
RNF169Ring finger protein 169. (615 aa)
HELBDNA helicase B. (1087 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (278 aa)
RIF1Replication timing regulatory factor 1. (2473 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (625 aa)
RBBP8RB binding protein 8, endonuclease. (895 aa)
ENSPPAP00000006492Uncharacterized protein. (228 aa)
LOC100979343Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (176 aa)
MMS22LMMS22 like, DNA repair protein. (1252 aa)
NKX3-1NK3 homeobox 1. (223 aa)
TCEB3CL2Uncharacterized protein. (298 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CBX5Chromobox 5. (191 aa)
RFWD3Ring finger and WD repeat domain 3. (774 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (600 aa)
RPA3Replication protein A3. (121 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2005 aa)
IFFO1Intermediate filament family orphan 1; Belongs to the intermediate filament family. (571 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
TRAIPTRAF interacting protein. (469 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
ENSPPAP00000026353Uncharacterized protein. (175 aa)
ENSPPAP00000016751Uncharacterized protein. (163 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (570 aa)
AUNIPAurora kinase A and ninein interacting protein. (371 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
WASWASP actin nucleation promoting factor. (502 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (259 aa)
PAXXPAXX non-homologous end joining factor. (204 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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