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| | BRCA2 | BRCA2 DNA repair associated. (3417 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1491 aa) |
| | EPHA2 | EPH receptor A2. (976 aa) |
| | DIABLO | Uncharacterized protein. (239 aa) |
| | RNF186 | Ring finger protein 186. (227 aa) |
| | ENSPPAP00000002562 | BZIP domain-containing protein. (314 aa) |
| | STK24 | Serine/threonine kinase 24. (443 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | ENSPPAP00000003962 | Uncharacterized protein. (69 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | PHLDA3 | Pleckstrin homology like domain family A member 3. (127 aa) |
| | JAK2 | Tyrosine-protein kinase. (1143 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | LOC100980724 | BZIP domain-containing protein. (359 aa) |
| | ENSPPAP00000004730 | HIT domain-containing protein. (160 aa) |
| | BCL2A1 | BCL2 related protein A1. (196 aa) |
| | COA8 | Cytochrome c oxidase assembly factor 8. (205 aa) |
| | MOAP1 | Modulator of apoptosis 1. (351 aa) |
| | PPP1R15A | Protein phosphatase 1 regulatory subunit 15A. (682 aa) |
| | NOX1 | NADPH oxidase 1. (564 aa) |
| | SHISA5 | Shisa family member 5. (247 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (963 aa) |
| | ENSPPAP00000006687 | Protein kinase domain-containing protein. (379 aa) |
| | STK25 | Serine/threonine kinase 25. (426 aa) |
| | E2F1 | E2F transcription factor 1. (397 aa) |
| | SIRT1 | Sirtuin 1. (693 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (232 aa) |
| | ELL3 | Elongation factor for RNA polymerase II 3. (397 aa) |
| | ENSPPAP00000007855 | Uncharacterized protein. (192 aa) |
| | RPS27L | 40S ribosomal protein S27. (100 aa) |
| | TMEM109 | Transmembrane protein 109. (243 aa) |
| | PDK2 | Protein-serine/threonine kinase. (407 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | QRICH1 | Glutamine rich 1. (776 aa) |
| | CD24 | CD24 molecule. (129 aa) |
| | ZNF622 | Zinc finger protein 622. (477 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | CRIP1 | LIM zinc-binding domain-containing protein. (77 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (795 aa) |
| | BAG6 | BCL2 associated athanogene 6. (1162 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (385 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | PML | Uncharacterized protein. (836 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | LOC100983911 | BZIP domain-containing protein. (318 aa) |
| | FNIP2 | Folliculin interacting protein 2. (1114 aa) |
| | IFI16 | Interferon gamma inducible protein 16. (733 aa) |
| | SKIL | SKI like proto-oncogene. (684 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | CHEK2 | FHA domain-containing protein. (229 aa) |
| | CLU | Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1832 aa) |
| | BRSK2 | BR serine/threonine kinase 2. (707 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1849 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (977 aa) |
| | MLH1 | MutL homolog 1. (756 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | IFI6 | Interferon alpha inducible protein 6. (134 aa) |
| | BCL2 | BCL2 apoptosis regulator. (193 aa) |
| | AIFM1 | Apoptosis inducing factor mitochondria associated 1. (613 aa) |
| | PDX1 | Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (263 aa) |
| | EP300 | E1A binding protein p300. (2411 aa) |
| | PDCD10 | Programmed cell death 10. (212 aa) |
| | NUPR1 | Nuclear protein 1, transcriptional regulator. (82 aa) |
| | IVNS1ABP | Influenza virus NS1A binding protein. (642 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (461 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | TMBIM6 | Transmembrane BAX inhibitor motif containing 6; Belongs to the BI1 family. (291 aa) |
| | ARL6IP5 | PRA1 family protein. (188 aa) |
| | MYBBP1A | MYB binding protein 1a. (1338 aa) |
| | BDKRB2 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (669 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa) |
| | CUL5 | Cullin 5; Belongs to the cullin family. (775 aa) |
| | GSKIP | GSK3B interacting protein. (147 aa) |
| | SIVA1 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa) |
| | POU4F2 | POU domain protein. (406 aa) |
| | ZNF385B | Zinc finger protein 385B. (471 aa) |
| | ERO1A | Endoplasmic reticulum oxidoreductase 1 alpha. (468 aa) |
| | CUL2 | Cullin 2; Belongs to the cullin family. (764 aa) |
| | HMOX1 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1210 aa) |
| | BCL2L10 | Uncharacterized protein. (204 aa) |
| | ATP2A1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (873 aa) |
| | CASP7 | Caspase 7; Belongs to the peptidase C14A family. (388 aa) |
| | CASP6 | Caspase 6; Belongs to the peptidase C14A family. (293 aa) |
| | FHIT | HIT domain-containing protein. (67 aa) |
| | TP73 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (605 aa) |
| | ERN2 | Endoplasmic reticulum to nucleus signaling 2. (926 aa) |
| | LOC100975953 | Uncharacterized protein. (678 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | JMY | Junction mediating and regulatory protein, p53 cofactor. (988 aa) |
| | WWOX | WW domain containing oxidoreductase. (414 aa) |
| | BCL3 | BCL3 transcription coactivator. (383 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1017 aa) |
| | MCL1 | MCL1 apoptosis regulator, BCL2 family member. (350 aa) |
| | LOC103786139 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (479 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | DAB2IP | DAB2 interacting protein. (1155 aa) |
| | PERP | P53 apoptosis effector related to PMP22. (193 aa) |
| | ENSPPAP00000032574 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (528 aa) |
| | ATF4 | Activating transcription factor 4. (340 aa) |
| | CASP12 | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa) |
| | HINT1 | Histidine triad nucleotide binding protein 1. (126 aa) |
| | AEN | Apoptosis enhancing nuclease. (325 aa) |
| | CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (264 aa) |
| | BBC3 | Uncharacterized protein. (131 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (218 aa) |
| | SCN2A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | DNAJC10 | DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (793 aa) |
| | NOL3 | CARD domain-containing protein. (219 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1356 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (456 aa) |
| | HTRA2 | HtrA serine peptidase 2. (458 aa) |
| | ENSPPAP00000036207 | Uncharacterized protein. (185 aa) |
| | SNW1 | SNW domain containing 1. (571 aa) |
| | TMEM117 | Transmembrane protein 117. (514 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1304 aa) |
| | SGPP1 | acidPPc domain-containing protein. (366 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (736 aa) |
| | USP28 | Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1177 aa) |
| | TP53BP2 | Tumor protein p53 binding protein 2. (1137 aa) |
| | LGALS12 | Galectin. (336 aa) |
| | ENSPPAP00000039346 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (627 aa) |
| | CASP4 | Caspase 4; Belongs to the peptidase C14A family. (321 aa) |
| | CDIP1 | Cell death inducing p53 target 1. (208 aa) |
| | PDK1 | Protein-serine/threonine kinase. (456 aa) |
| | BNIP3 | BCL2 interacting protein 3. (252 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | TOPORS | TOP1 binding arginine/serine rich protein. (1044 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (212 aa) |
| | HIPK2 | Protein kinase domain-containing protein. (954 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (421 aa) |
| | PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1090 aa) |
| | CIDEB | Cell death inducing DFFA like effector b. (219 aa) |
| | LOC100989599 | Uncharacterized protein; Belongs to the cytochrome P450 family. (339 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (609 aa) |
| | ENSPPAP00000042767 | SKIP_SNW domain-containing protein. (390 aa) |
| | FLCN | Folliculin. (579 aa) |
| | PPM1F | Protein phosphatase, Mg2+/Mn2+ dependent 1F. (454 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa) |
| | MELK | Non-specific serine/threonine protein kinase. (651 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | EDA2R | Ectodysplasin A2 receptor. (297 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (439 aa) |
| | SELENOK | Selenoprotein K. (89 aa) |
| | LOC100981047 | Shisa family member 5. (137 aa) |
