(82 nodes) Cellular response to virus network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IFI6	Interferon alpha inducible protein 6. (134 aa)
	ADAR	A to I editase domain-containing protein. (193 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	IFNGR1	Interferon gamma receptor 1. (489 aa)
	IFNA7	Interferon alpha 7. (189 aa)
	CCL19	C-C motif chemokine. (98 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	VWCE	Von Willebrand factor C and EGF domains. (955 aa)
	LGALS8	Galectin. (303 aa)
	IFNAR2	Uncharacterized protein. (519 aa)
	RRP1B	Ribosomal RNA processing 1B. (747 aa)
	IL6	Uncharacterized protein. (198 aa)
	IRF3	Interferon regulatory factor 3. (452 aa)
	MAPK11	Mitogen-activated protein kinase. (325 aa)
	GLI2	GLI family zinc finger 2. (1587 aa)
	PHB2	Prohibitin. (299 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
	CXCL10	C-X-C motif chemokine. (96 aa)
	ENSPPAP00000030479	Prohibitin. (194 aa)
	POU2F2	POU domain protein. (614 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	POU2AF1	POU class 2 homeobox associating factor 1. (256 aa)
	PHB	Prohibitin. (272 aa)
	IFNGR2	Interferon gamma receptor 2. (347 aa)
	IFNW1	Interferon omega 1. (200 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	GSDME	Gasdermin E. (496 aa)
	IFNL1	Interferon lambda 1. (200 aa)
	JAK2	Tyrosine-protein kinase. (1143 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (704 aa)
	JAK1	Tyrosine-protein kinase. (1153 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (558 aa)
	NLRP3	NLR family pyrin domain containing 3. (1036 aa)
	IFNA8	Interferon alpha 8. (189 aa)
	IFNE	Interferon epsilon. (208 aa)
	IL10RB	Interleukin 10 receptor subunit beta. (325 aa)
	IFNA10	Interferon alpha 10. (189 aa)
	IFNA5	Interferon alpha 5. (189 aa)
	LOC100972005	Uncharacterized protein. (198 aa)
	IFNA6	Interferon alpha 6. (189 aa)
	MMP12	Matrix metallopeptidase 12. (470 aa)
	IFNA14	Interferon alpha 14. (189 aa)
	CALR	Calreticulin. (417 aa)
	IFNA17	Interferon alpha 17. (189 aa)
	WDFY4	WDFY family member 4. (3184 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (850 aa)
	ARF1	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	OAS1	2',5'-oligoadenylate synthetase 1. (401 aa)
	LOC100989808	Prohibitin. (258 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1025 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	IFNLR1	Interferon lambda receptor 1. (519 aa)
	ZC3HAV1	Uncharacterized protein. (1024 aa)
	TYK2	Tyrosine-protein kinase. (1190 aa)
	LOC100972230	Uncharacterized protein. (458 aa)
	BAX	BCL2 associated X, apoptosis regulator. (218 aa)
	IFNL2	Interferon lambda 2. (196 aa)
	LGALS9	Galectin. (355 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (599 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
	FMR1	Fragile X mental retardation 1. (615 aa)
	LSM14A	Uncharacterized protein. (477 aa)
	OAS3	2'-5'-oligoadenylate synthetase 3. (1082 aa)
	GBF1	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1859 aa)
	PENK	Proenkephalin. (267 aa)
	CCL5	C-C motif chemokine. (91 aa)
	ENSPPAP00000042813	Prohibitin. (250 aa)
	IRF7	Interferon regulatory factor 7. (516 aa)
	RIOK3	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (603 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (608 aa)
	IRGM	Immunity related GTPase M. (195 aa)
	DHX58	DExH-box helicase 58. (678 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	ENSPPAP00000016834	Uncharacterized protein. (195 aa)
	RNF135	B30.2/SPRY domain-containing protein. (370 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	ENSPPAP00000017085	Prohibitin. (177 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	DDX58	ENSPPAP00000017853	ENSPPAP00000038038	A to I editase domain-containing protein.	DExD/H-box helicase 58.	0.562
ADAR	DHX58	ENSPPAP00000017853	ENSPPAP00000015998	A to I editase domain-containing protein.	DExH-box helicase 58.	0.436
ADAR	FMR1	ENSPPAP00000017853	ENSPPAP00000038945	A to I editase domain-containing protein.	Fragile X mental retardation 1.	0.475
ADAR	IFIH1	ENSPPAP00000017853	ENSPPAP00000031468	A to I editase domain-containing protein.	Interferon induced with helicase C domain 1.	0.627
ADAR	IRF7	ENSPPAP00000017853	ENSPPAP00000014100	A to I editase domain-containing protein.	Interferon regulatory factor 7.	0.530
ADAR	OAS1	ENSPPAP00000017853	ENSPPAP00000013370	A to I editase domain-containing protein.	2',5'-oligoadenylate synthetase 1.	0.485
ADAR	OAS3	ENSPPAP00000017853	ENSPPAP00000040293	A to I editase domain-containing protein.	2'-5'-oligoadenylate synthetase 3.	0.449
ARF1	GBF1	ENSPPAP00000012887	ENSPPAP00000040560	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	Golgi brefeldin A resistant guanine nucleotide exchange factor 1.	0.865
ATF2	IRF3	ENSPPAP00000008977	ENSPPAP00000025254	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Interferon regulatory factor 3.	0.943
ATF2	IRF7	ENSPPAP00000008977	ENSPPAP00000014100	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Interferon regulatory factor 7.	0.488
ATF2	MAPK11	ENSPPAP00000008977	ENSPPAP00000025888	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Mitogen-activated protein kinase.	0.987
ATF2	MAPK14	ENSPPAP00000008977	ENSPPAP00000038351	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Mitogen-activated protein kinase.	0.995
CALR	IL6	ENSPPAP00000001484	ENSPPAP00000025189	Calreticulin.	Uncharacterized protein.	0.408
CALR	JAK2	ENSPPAP00000001484	ENSPPAP00000004553	Calreticulin.	Tyrosine-protein kinase.	0.589
CCL19	CCL5	ENSPPAP00000020066	ENSPPAP00000042652	C-C motif chemokine.	C-C motif chemokine.	0.467
CCL19	CXCL10	ENSPPAP00000020066	ENSPPAP00000030363	C-C motif chemokine.	C-X-C motif chemokine.	0.701
CCL5	CCL19	ENSPPAP00000042652	ENSPPAP00000020066	C-C motif chemokine.	C-C motif chemokine.	0.467
CCL5	CXCL10	ENSPPAP00000042652	ENSPPAP00000030363	C-C motif chemokine.	C-X-C motif chemokine.	0.999
CCL5	DDX58	ENSPPAP00000042652	ENSPPAP00000038038	C-C motif chemokine.	DExD/H-box helicase 58.	0.566
CCL5	ENSPPAP00000016834	ENSPPAP00000042652	ENSPPAP00000016834	C-C motif chemokine.	Uncharacterized protein.	0.516