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| | DNASE2B | Deoxyribonuclease 2 beta. (361 aa) |
| | SHPRH | SNF2 histone linker PHD RING helicase. (1673 aa) |
| | MLH1 | MutL homolog 1. (756 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (532 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | ENSPPAP00000016638 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (612 aa) |
| | ENSPPAP00000016729 | Ribosomal_S3_C domain-containing protein. (100 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (869 aa) |
| | ERCC6L | ERCC excision repair 6 like, spindle assembly checkpoint helicase. (1250 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | MYO18A | Myosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2050 aa) |
| | TDG | Thymine DNA glycosylase. (410 aa) |
| | TM4SF19 | Uncharacterized protein. (299 aa) |
| | BLM | BLM RecQ like helicase. (1417 aa) |
| | THAP9 | THAP domain containing 9. (903 aa) |
| | MEIOB | Uncharacterized protein. (344 aa) |
| | DNASE1 | Deoxyribonuclease; Belongs to the DNase I family. (282 aa) |
| | RAD51C | RAD51 paralog C. (376 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | SMARCAD1 | Uncharacterized protein. (1026 aa) |
| | GTF2F2 | General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (396 aa) |
| | ERCC3 | ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa) |
| | ENSPPAP00000026192 | Uncharacterized protein. (86 aa) |
| | MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (574 aa) |
| | WRN | WRN RecQ like helicase. (1405 aa) |
| | ENSPPAP00000027667 | Uncharacterized protein. (98 aa) |
| | NEIL2 | Nei like DNA glycosylase 2. (384 aa) |
| | MSH4 | MutS homolog 4. (936 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1249 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1060 aa) |
| | DNASE1L2 | Deoxyribonuclease; Belongs to the DNase I family. (299 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (547 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (669 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1318 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | PRIMPOL | Uncharacterized protein. (431 aa) |
| | ENSPPAP00000000062 | MTS domain-containing protein. (220 aa) |
| | HELLS | Helicase, lymphoid specific. (884 aa) |
| | ZGRF1 | Zinc finger GRF-type containing 1. (2103 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa) |
| | SETX | Senataxin. (2669 aa) |
| | HELQ | Helicase, POLQ like. (1101 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1491 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | SUB1 | SUB1 regulator of transcription. (127 aa) |
| | C17orf64 | Chromosome 17 open reading frame 64. (236 aa) |
| | DFFB | DNA fragmentation factor subunit beta. (362 aa) |
| | ALKBH4 | AlkB homolog 4, lysine demethylase. (302 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (932 aa) |
| | PTGES3 | Prostaglandin E synthase 3. (164 aa) |
| | DNASE1L1 | Deoxyribonuclease; Belongs to the DNase I family. (302 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (771 aa) |
| | ENSPPAP00000003540 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1088 aa) |
| | PLD3 | Phospholipase D family member 3. (490 aa) |
| | ENSPPAP00000004806 | Uncharacterized protein. (142 aa) |
| | DHX36 | DEAH-box helicase 36. (1009 aa) |
| | RSF1 | Remodeling and spacing factor 1. (1187 aa) |
| | HELB | DNA helicase B. (1087 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa) |
| | TREX1 | Three prime repair exonuclease 1. (369 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (514 aa) |
| | ENSPPAP00000005982 | Uncharacterized protein. (84 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | HFM1 | Helicase for meiosis 1. (1324 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (895 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | POLK | DNA polymerase kappa. (897 aa) |
| | RAD51D | RAD51 paralog D. (348 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (596 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1143 aa) |
| | POLQ | DNA polymerase theta. (2731 aa) |
| | IGHMBP2 | Immunoglobulin mu DNA binding protein 2. (997 aa) |
| | MPHOSPH9 | M-phase phosphoprotein 9. (1183 aa) |
| | DDX1 | DEAD-box helicase 1. (740 aa) |
| | TTF2 | Transcription termination factor 2. (1162 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1637 aa) |
| | G3BP1 | G3BP stress granule assembly factor 1. (466 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (238 aa) |
| | ENSPPAP00000008914 | Uncharacterized protein. (164 aa) |
| | CEP41 | Centrosomal protein 41. (373 aa) |
| | FTO | FTO alpha-ketoglutarate dependent dioxygenase. (559 aa) |
| | ENSPPAP00000009744 | Uncharacterized protein. (495 aa) |
| | CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (840 aa) |
| | PGBD5 | PiggyBac transposable element derived 5. (455 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | ALKBH3 | AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (286 aa) |
| | ENSPPAP00000011209 | EP400_N domain-containing protein. (419 aa) |
| | ISG20 | Interferon stimulated exonuclease gene 20. (179 aa) |
| | FANCM | FA complementation group M. (2048 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (344 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (362 aa) |
| | CHD4 | Uncharacterized protein. (1914 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | RAD54L2 | RAD54 like 2. (1467 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa) |
| | ENSPPAP00000031315 | Uncharacterized protein. (560 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] (318 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1566 aa) |
| | CHD1L | Chromodomain helicase DNA binding protein 1 like. (921 aa) |
| | CECR2 | CECR2 histone acetyl-lysine reader. (1443 aa) |
| | CHD9 | Uncharacterized protein. (2383 aa) |
| | ENSPPAP00000033446 | KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (253 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | REXO2 | RNA exonuclease 2. (237 aa) |
| | SETMAR | SET domain and mariner transposase fusion gene. (684 aa) |
| | ENSPPAP00000034007 | Protein kinase domain-containing protein. (324 aa) |
| | LOC100993364 | Uncharacterized protein. (106 aa) |
| | ENSPPAP00000034340 | NTF2 domain-containing protein. (394 aa) |
| | NEIL1 | Nei like DNA glycosylase 1. (390 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2573 aa) |
| | MSH5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (839 aa) |
| | ENSPPAP00000034890 | Uncharacterized protein. (126 aa) |
| | RAD51B | RAD51 paralog B. (359 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa) |
| | MPG | N-methylpurine DNA glycosylase. (284 aa) |
| | ENDOG | Endonuclease. (188 aa) |
| | ENSPPAP00000036860 | Uncharacterized protein. (189 aa) |
| | LOC100992102 | CS domain-containing protein. (137 aa) |
| | EP400 | E1A binding protein p400. (2918 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1304 aa) |
| | ALKBH1 | AlkB homolog 1, histone H2A dioxygenase. (389 aa) |
| | LOC100989432 | UDG domain-containing protein. (405 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | PLD4 | Phospholipase D family member 4. (515 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa) |
| | RFC1 | Replication factor C subunit 1. (1148 aa) |
| | INO80 | INO80 complex ATPase subunit. (1556 aa) |
| | ARID3A | Uncharacterized protein. (373 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (590 aa) |
| | ENSPPAP00000039065 | Uncharacterized protein. (350 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | FEN1-2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (308 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (954 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (146 aa) |
| | DNASE1L3 | Deoxyribonuclease; Belongs to the DNase I family. (305 aa) |
| | POLN | DNA polymerase nu. (900 aa) |
| | POLA1 | DNA polymerase. (1468 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1234 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (765 aa) |
| | CHD1 | Chromodomain helicase DNA binding protein 1. (1699 aa) |
| | ENSPPAP00000041743 | Uncharacterized protein. (572 aa) |
| | MLH3 | MutL homolog 3. (1450 aa) |
| | CHD6 | Chromodomain helicase DNA binding protein 6. (2687 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1521 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (1040 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | ATRX | ATRX chromatin remodeler. (2492 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1096 aa) |
| | BTAF1 | B-TFIID TATA-box binding protein associated factor 1. (1849 aa) |
| | ENSPPAP00000042766 | SAP domain-containing protein. (225 aa) |
| | FBH1 | F-box DNA helicase 1. (1096 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | ERCC2 | ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa) |
| | ENSPPAP00000043136 | FPG-type domain-containing protein. (297 aa) |
| | TATDN1 | TatD DNase domain containing 1. (333 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | ENSPPAP00000019077 | Uncharacterized protein. (54 aa) |
| | EXOG | Exo/endonuclease G. (368 aa) |
| | HAUS3 | HAUS augmin like complex subunit 3. (596 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | CHD3 | Chromodomain helicase DNA binding protein 3. (2012 aa) |
| | TEP1 | Telomerase associated protein 1. (2626 aa) |
| | POLI | DNA polymerase iota. (660 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (485 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | CHD7 | Chromodomain helicase DNA binding protein 7. (2997 aa) |
| | RTEL1-2 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1103 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | ENSPPAP00000020688 | Uncharacterized protein. (80 aa) |
| | C11orf80 | Chromosome 11 open reading frame 80. (572 aa) |
| | TENT4B | Terminal nucleotidyltransferase 4B. (593 aa) |
| | SMUG1 | Single-strand-selective monofunctional uracil-DNA glycosylase 1. (270 aa) |
| | APLF | Aprataxin and PNKP like factor. (511 aa) |
| | ENSPPAP00000020965 | KH type-2 domain-containing protein. (250 aa) |
| | MCM8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (843 aa) |
| | NAV2 | Neuron navigator 2. (2488 aa) |
| | ALKBH2 | AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase. (261 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1113 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) |
| | CHD5 | Chromodomain helicase DNA binding protein 5. (1928 aa) |
| | LIG3 | DNA ligase. (1008 aa) |
| | DNASE2 | Deoxyribonuclease 2, lysosomal. (360 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | N6AMT1 | N-6 adenine-specific DNA methyltransferase 1. (214 aa) |
| | CHRAC1 | Chromatin accessibility complex subunit 1. (121 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (572 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (998 aa) |
| | TOP1MT | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (584 aa) |
| | DNMT3B | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (853 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | SUPV3L1 | Suv3 like RNA helicase. (786 aa) |
| | ENSPPAP00000022942 | Ku domain-containing protein. (338 aa) |
| | ENDOV | Endonuclease V. (309 aa) |
| | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1070 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3130 aa) |
| | DQX1 | DEAQ-box RNA dependent ATPase 1. (732 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa) |
| | ENSPPAP00000011953 | Ku domain-containing protein. (586 aa) |
| | TWNK | Twinkle mtDNA helicase. (582 aa) |
| | ERCC6L2 | ERCC excision repair 6 like 2. (712 aa) |
| | DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa) |
| | NEIL3 | Nei like DNA glycosylase 3. (598 aa) |
| | RPS3 | Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | OGG1 | ENDO3c domain-containing protein. (345 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (608 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1078 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1040 aa) |
| | POLD1 | DNA polymerase. (1133 aa) |
| | DHX9 | DExH-box helicase 9. (1270 aa) |
| | MUTYH | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (612 aa) |
| | APTX | Aprataxin. (354 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (635 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1832 aa) |
| | METTL4 | Methyltransferase like 4; Belongs to the MT-A70-like family. (472 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (116 aa) |
| | SRCAP | Uncharacterized protein. (3165 aa) |
| | CHD2 | Uncharacterized protein. (1820 aa) |
| | ENSPPAP00000014996 | Uncharacterized protein. (108 aa) |
| | TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1619 aa) |
| | ASCC3 | Activating signal cointegrator 1 complex subunit 3. (2202 aa) |
| | HLTF | Helicase like transcription factor. (1013 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa) |
| | HMGA1 | Uncharacterized protein. (201 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1251 aa) |
