STRINGSTRING
XRN1 XRN1 ENSPPAP00000000081 ENSPPAP00000000081 TEN1 TEN1 ENSPPAP00000042654 ENSPPAP00000042654 SLX4 SLX4 TERF2 TERF2 ENSPPAP00000040316 ENSPPAP00000040316 DCP2 DCP2 PARP1 PARP1 CTC1 CTC1 SRC SRC MCRS1 MCRS1 TNKS2 TNKS2 ENSPPAP00000034922 ENSPPAP00000034922 HNRNPU HNRNPU EXOSC10 EXOSC10 POT1 POT1 TERF1 TERF1 ENSPPAP00000026641 ENSPPAP00000026641 NAT10 NAT10 ERCC4 ERCC4 GNL3L GNL3L TENT4B TENT4B ENSPPAP00000020451 ENSPPAP00000020451 STN1 STN1 PINX1 PINX1 PML PML TNKS TNKS PIF1 PIF1 TINF2 TINF2 ACD ACD HNRNPA1 HNRNPA1 SLX1A SLX1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XRN15'-3' exoribonuclease 1. (1706 aa)
ENSPPAP00000000081Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (369 aa)
TEN1Uncharacterized protein. (123 aa)
ENSPPAP00000042654HTH myb-type domain-containing protein. (247 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1833 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (472 aa)
ENSPPAP00000040316Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (403 aa)
DCP2Decapping mRNA 2. (417 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
SRCTyrosine-protein kinase. (458 aa)
MCRS1Microspherule protein 1. (475 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
ENSPPAP00000034922G domain-containing protein. (487 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
EXOSC10Exosome component 10. (890 aa)
POT1Protection of telomeres 1. (634 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (440 aa)
ENSPPAP00000026641Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1034 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
GNL3LG protein nucleolar 3 like. (582 aa)
TENT4BTerminal nucleotidyltransferase 4B. (593 aa)
ENSPPAP00000020451RRM domain-containing protein. (259 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (332 aa)
PMLUncharacterized protein. (836 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (596 aa)
TINF2TERF1 interacting nuclear factor 2. (453 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (458 aa)
HNRNPA1Heterogeneous nuclear ribonucleoprotein A1. (372 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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