STRINGSTRING
TRIM28 TRIM28 GTF2F1 GTF2F1 LOC100989024 LOC100989024 E2F4 E2F4 NDN NDN ENSPPAP00000002562 ENSPPAP00000002562 KLF4 KLF4 SUZ12 SUZ12 LOC100980724 LOC100980724 IKZF3 IKZF3 PRDM1 PRDM1 SIRT1 SIRT1 DNMT1 DNMT1 ATF2 ATF2 SOX10 SOX10 TP53 TP53 HSF1 HSF1 MACROH2A1 MACROH2A1 ZNF304 ZNF304 LOC100983911 LOC100983911 PCGF1 PCGF1 EGR1 EGR1 DHX9 DHX9 WDR13 WDR13 FOXO1 FOXO1 PRDM15 PRDM15 EHMT2 EHMT2 FOXO4 FOXO4 EZH2 EZH2 NRL NRL HDAC1 HDAC1 ENSPPAP00000019077 ENSPPAP00000019077 HDAC2 HDAC2 CHD7 CHD7 SMAD3 SMAD3 MECP2 MECP2 ISL1 ISL1 POU4F2 POU4F2 NUP98 NUP98 IRF3 IRF3 ERCC4 ERCC4 ERCC3 ERCC3 MYOD1 MYOD1 TAF10 TAF10 GLI2 GLI2 RBL2 RBL2 ZC3H4 ZC3H4 PCGF2 PCGF2 NIPBL NIPBL TRO TRO RBL1 RBL1 ZNF750 ZNF750 ZNF683 ZNF683 HNRNPU HNRNPU ATF4 ATF4 MAGED2 MAGED2 STAT1 STAT1 ZNF609 ZNF609 GTF2B GTF2B MED1 MED1 SETDB1 SETDB1 DDX5 DDX5 KDM1A KDM1A GADD45A GADD45A ENSPPAP00000039065 ENSPPAP00000039065 ERCC1 ERCC1 POLR2A POLR2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRIM28Tripartite motif containing 28. (736 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (516 aa)
LOC100989024E2F_TDP domain-containing protein. (407 aa)
E2F4E2F_TDP domain-containing protein. (416 aa)
NDNMAGE domain-containing protein. (261 aa)
ENSPPAP00000002562BZIP domain-containing protein. (314 aa)
KLF4Kruppel like factor 4. (477 aa)
SUZ12VEFS-Box domain-containing protein. (398 aa)
LOC100980724BZIP domain-containing protein. (359 aa)
IKZF3IKAROS family zinc finger 3. (509 aa)
PRDM1PR/SET domain 1. (825 aa)
SIRT1Sirtuin 1. (693 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1637 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SOX10SRY-box transcription factor 10. (466 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
HSF1Heat shock transcription factor 1. (490 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
ZNF304Zinc finger protein 304. (705 aa)
LOC100983911BZIP domain-containing protein. (318 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
DHX9DExH-box helicase 9. (1270 aa)
WDR13WD repeat domain 13. (485 aa)
FOXO1Fork-head domain-containing protein. (527 aa)
PRDM15PR/SET domain 15. (1469 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1278 aa)
FOXO4Forkhead box O4. (505 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
NRLNeural retina leucine zipper. (237 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ENSPPAP00000019077Uncharacterized protein. (54 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (510 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (493 aa)
ISL1ISL LIM homeobox 1. (349 aa)
POU4F2POU domain protein. (406 aa)
NUP98Nucleoporin 98. (1807 aa)
IRF3Interferon regulatory factor 3. (452 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
GLI2GLI family zinc finger 2. (1587 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
ZC3H4Zinc finger CCCH-type containing 4. (1305 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
NIPBLNipped-B protein. (2804 aa)
TROTrophinin. (1431 aa)
RBL1RB transcriptional corepressor like 1. (1049 aa)
ZNF750Zinc finger protein 750. (723 aa)
ZNF683Zinc finger protein 683. (524 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
ATF4Activating transcription factor 4. (340 aa)
MAGED2MAGE family member D2. (606 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
ZNF609Zinc finger protein 609. (1411 aa)
GTF2BGeneral transcription factor IIB. (348 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1555 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1292 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
ENSPPAP00000039065Uncharacterized protein. (350 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (2015 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.