(8 nodes) Positive regulation of chemokine (C-X-C motif) ligand 2 production network (Pan paniscus)

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Your Input:
	CD74	CD74 molecule. (296 aa)
	MCOLN2	Mucolipin 2. (566 aa)
	MIF	Macrophage migration inhibitory factor. (115 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	MBP	Uncharacterized protein. (318 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	TIRAP	TIR domain-containing protein. (226 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD74	MIF	ENSPPAP00000028894	ENSPPAP00000017815	CD74 molecule.	Macrophage migration inhibitory factor.	0.969
CD74	TLR4	ENSPPAP00000028894	ENSPPAP00000016171	CD74 molecule.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.475
MBP	TNF	ENSPPAP00000013614	ENSPPAP00000004174	Uncharacterized protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.484
MIF	CD74	ENSPPAP00000017815	ENSPPAP00000028894	Macrophage migration inhibitory factor.	CD74 molecule.	0.969
MIF	TNF	ENSPPAP00000017815	ENSPPAP00000004174	Macrophage migration inhibitory factor.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.487
TIRAP	TLR4	ENSPPAP00000001223	ENSPPAP00000016171	TIR domain-containing protein.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.995
TIRAP	TNF	ENSPPAP00000001223	ENSPPAP00000004174	TIR domain-containing protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.573
TLR4	CD74	ENSPPAP00000016171	ENSPPAP00000028894	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	CD74 molecule.	0.475
TLR4	TIRAP	ENSPPAP00000016171	ENSPPAP00000001223	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	TIR domain-containing protein.	0.995
TLR4	TNF	ENSPPAP00000016171	ENSPPAP00000004174	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.717
TNF	MBP	ENSPPAP00000004174	ENSPPAP00000013614	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.484
TNF	MIF	ENSPPAP00000004174	ENSPPAP00000017815	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Macrophage migration inhibitory factor.	0.487
TNF	TIRAP	ENSPPAP00000004174	ENSPPAP00000001223	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	TIR domain-containing protein.	0.573
TNF	TLR4	ENSPPAP00000004174	ENSPPAP00000016171	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.717