STRINGSTRING
ZBTB7B ZBTB7B TWSG1 TWSG1 PRKCQ PRKCQ BCL6 BCL6 IL2 IL2 ANXA1 ANXA1 CD81 CD81 SMAD7 SMAD7 VSIR VSIR CD3E CD3E HLX HLX MYB MYB TNFSF4 TNFSF4 CBLB CBLB CD160 CD160 IL27 IL27 CCL19 CCL19 SHB SHB CD86 CD86 ENSPPAP00000021246 ENSPPAP00000021246 TBX21 TBX21 SH3RF1 SH3RF1 NFKBIZ NFKBIZ RUNX3 RUNX3 CD28 CD28 ENSPPAP00000023714 ENSPPAP00000023714 CARD11 CARD11 IL12RB1 IL12RB1 AGER AGER RC3H2 RC3H2 SASH3 SASH3 RIPK2 RIPK2 RARA RARA TGFBR2 TGFBR2 ITCH ITCH IL23A IL23A PRKCZ PRKCZ ARG2 ARG2 LOC100981622 LOC100981622 IFNG IFNG GIMAP1 GIMAP1 HLA-DRA HLA-DRA CD83 CD83 IL4R IL4R ZC3H12A ZC3H12A IRF4 IRF4 JAK3 JAK3 LGALS9 LGALS9 IL2RG IL2RG LOC100991923 LOC100991923 CD80 CD80 RC3H1 RC3H1 NFKBID NFKBID NCKAP1L NCKAP1L BATF BATF MALT1 MALT1 IL12B IL12B IL2RA IL2RA SOCS5 SOCS5 TNFSF18 TNFSF18 RUNX1 RUNX1 NLRP3 NLRP3 TARM1 TARM1 ENSPPAP00000004517 ENSPPAP00000004517 LOXL3 LOXL3 IL23R IL23R JUNB JUNB NDFIP1 NDFIP1 GATA3 GATA3 IL4 IL4 IL18 IL18 FOXP3 FOXP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (758 aa)
BCL6BCL6 transcription repressor. (706 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
ANXA1Annexin. (346 aa)
CD81Tetraspanin. (270 aa)
SMAD7MH2 domain-containing protein. (211 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
CD3ECD3e molecule. (207 aa)
HLXH2.0 like homeobox. (493 aa)
MYBMYB proto-oncogene, transcription factor. (768 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
CBLBCbl proto-oncogene B. (982 aa)
CD160Uncharacterized protein. (234 aa)
IL27Uncharacterized protein. (154 aa)
CCL19C-C motif chemokine. (98 aa)
SHBSH2 domain-containing protein. (285 aa)
CD86CD86 molecule. (329 aa)
ENSPPAP00000021246SOCS box domain-containing protein. (478 aa)
TBX21T-box transcription factor 21. (494 aa)
SH3RF1SH3 domain containing ring finger 1. (888 aa)
NFKBIZNFKB inhibitor zeta. (706 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
CD28CD28 molecule. (220 aa)
ENSPPAP00000023714Uncharacterized protein. (82 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (662 aa)
AGERAdvanced glycosylation end-product specific receptor. (420 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
RARAUncharacterized protein. (609 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
ITCHE3 ubiquitin-protein ligase. (870 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
ARG2Arginase. (354 aa)
LOC100981622Galectin. (136 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
GIMAP1Uncharacterized protein. (500 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
CD83CD83 molecule. (205 aa)
IL4RInterleukin 4 receptor. (873 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
IRF4Interferon regulatory factor 4. (392 aa)
JAK3Tyrosine-protein kinase. (1090 aa)
LGALS9Galectin. (355 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
LOC100991923Galectin. (111 aa)
CD80CD80 molecule. (288 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
NFKBIDANK_REP_REGION domain-containing protein. (465 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
MALT1MALT1 paracaspase. (786 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IL2RASushi domain-containing protein. (249 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
TNFSF18TNF superfamily member 18. (199 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
NLRP3NLR family pyrin domain containing 3. (1036 aa)
TARM1T cell-interacting, activating receptor on myeloid cells 1. (273 aa)
ENSPPAP00000004517Uncharacterized protein. (654 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
IL23RInterleukin 23 receptor. (629 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
NDFIP1Nedd4 family interacting protein 1. (200 aa)
GATA3GATA binding protein 3. (444 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
FOXP3Forkhead box P3. (441 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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