(39 nodes) Positive regulation of CD4-positive, alpha-beta T cell activation network (Pan paniscus)

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Known Interactions

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Predicted Interactions

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Your Input:
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	NLRP3	NLR family pyrin domain containing 3. (1036 aa)
	IL23R	Interleukin 23 receptor. (629 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	FOXP3	Forkhead box P3. (441 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (758 aa)
	ANXA1	Annexin. (346 aa)
	CD81	Tetraspanin. (270 aa)
	CD3E	CD3e molecule. (207 aa)
	HLX	H2.0 like homeobox. (493 aa)
	MYB	MYB proto-oncogene, transcription factor. (768 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	CCL19	C-C motif chemokine. (98 aa)
	SHB	SH2 domain-containing protein. (285 aa)
	CD86	CD86 molecule. (329 aa)
	ENSPPAP00000021246	SOCS box domain-containing protein. (478 aa)
	NFKBIZ	NFKB inhibitor zeta. (706 aa)
	CD28	CD28 molecule. (220 aa)
	CARD11	Caspase recruitment domain family member 11. (1154 aa)
	IL12RB1	Interleukin 12 receptor subunit beta 1. (662 aa)
	ZBTB7B	Zinc finger and BTB domain containing 7B. (573 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	MALT1	MALT1 paracaspase. (786 aa)
	NCKAP1L	NCK associated protein 1 like. (1127 aa)
	NFKBID	ANK_REP_REGION domain-containing protein. (465 aa)
	CD80	CD80 molecule. (288 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (369 aa)
	LGALS9	Galectin. (355 aa)
	IL4R	Interleukin 4 receptor. (873 aa)
	CD83	CD83 molecule. (205 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
	GIMAP1	Uncharacterized protein. (500 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
	RARA	Uncharacterized protein. (609 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA1	CD81	ENSPPAP00000014806	ENSPPAP00000014953	Annexin.	Tetraspanin.	0.470
CARD11	CD28	ENSPPAP00000023842	ENSPPAP00000023667	Caspase recruitment domain family member 11.	CD28 molecule.	0.779
CARD11	MALT1	ENSPPAP00000023842	ENSPPAP00000028489	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.999
CARD11	PRKCQ	ENSPPAP00000023842	ENSPPAP00000010905	Caspase recruitment domain family member 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.995
CARD11	RIPK2	ENSPPAP00000023842	ENSPPAP00000042959	Caspase recruitment domain family member 11.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.571
CCL19	CD80	ENSPPAP00000020066	ENSPPAP00000033006	C-C motif chemokine.	CD80 molecule.	0.434
CCL19	IFNG	ENSPPAP00000020066	ENSPPAP00000038608	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.454
CD28	CARD11	ENSPPAP00000023667	ENSPPAP00000023842	CD28 molecule.	Caspase recruitment domain family member 11.	0.779
CD28	CD3E	ENSPPAP00000023667	ENSPPAP00000017506	CD28 molecule.	CD3e molecule.	0.616
CD28	CD80	ENSPPAP00000023667	ENSPPAP00000033006	CD28 molecule.	CD80 molecule.	0.999
CD28	CD83	ENSPPAP00000023667	ENSPPAP00000037879	CD28 molecule.	CD83 molecule.	0.565
CD28	CD86	ENSPPAP00000023667	ENSPPAP00000021183	CD28 molecule.	CD86 molecule.	0.999
CD28	FOXP3	ENSPPAP00000023667	ENSPPAP00000009817	CD28 molecule.	Forkhead box P3.	0.733
CD28	HLA-DRA	ENSPPAP00000023667	ENSPPAP00000038215	CD28 molecule.	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family.	0.415
CD28	IFNG	ENSPPAP00000023667	ENSPPAP00000038608	CD28 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.811
CD28	IL23R	ENSPPAP00000023667	ENSPPAP00000004750	CD28 molecule.	Interleukin 23 receptor.	0.499
CD28	IL2RG	ENSPPAP00000023667	ENSPPAP00000034671	CD28 molecule.	Fibronectin type-III domain-containing protein.	0.436
CD28	LGALS9	ENSPPAP00000023667	ENSPPAP00000035280	CD28 molecule.	Galectin.	0.486
CD28	MALT1	ENSPPAP00000023667	ENSPPAP00000028489	CD28 molecule.	MALT1 paracaspase.	0.540
CD28	PRKCQ	ENSPPAP00000023667	ENSPPAP00000010905	CD28 molecule.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.971