(23 nodes) Positive regulation of transcription regulatory region DNA binding network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	CTNNB1	Catenin beta 1. (781 aa)
	ENSPPAP00000033668	Uncharacterized protein. (85 aa)
	GTF2B	General transcription factor IIB. (348 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (173 aa)
	PAX6	Uncharacterized protein. (467 aa)
	IL32	Interleukin 32. (234 aa)
	EP300	E1A binding protein p300. (2411 aa)
	RB1	RB transcriptional corepressor 1. (911 aa)
	HAND2	Uncharacterized protein. (66 aa)
	KLF4	Kruppel like factor 4. (477 aa)
	IGF1	IlGF domain-containing protein. (196 aa)
	ENSPPAP00000004994	TNF receptor-associated factor. (475 aa)
	H1-0	H1 histone family member 0. (194 aa)
	GATA3	GATA binding protein 3. (444 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	NIBAN2	Niban apoptosis regulator 2. (746 aa)
	DDRGK1	DDRGK domain containing 1. (314 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	ENSPPAP00000023305	DJ-1_PfpI domain-containing protein. (168 aa)
	POU4F2	POU domain protein. (406 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	EP300	ENSPPAP00000024694	ENSPPAP00000019195	Catenin beta 1.	E1A binding protein p300.	0.998
CTNNB1	H1-0	ENSPPAP00000024694	ENSPPAP00000006773	Catenin beta 1.	H1 histone family member 0.	0.476
CTNNB1	IFNG	ENSPPAP00000024694	ENSPPAP00000038608	Catenin beta 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.547
CTNNB1	IGF1	ENSPPAP00000024694	ENSPPAP00000003648	Catenin beta 1.	IlGF domain-containing protein.	0.536
CTNNB1	KLF4	ENSPPAP00000024694	ENSPPAP00000003618	Catenin beta 1.	Kruppel like factor 4.	0.841
CTNNB1	PARP1	ENSPPAP00000024694	ENSPPAP00000036168	Catenin beta 1.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.523
CTNNB1	PAX6	ENSPPAP00000024694	ENSPPAP00000042369	Catenin beta 1.	Uncharacterized protein.	0.464
CTNNB1	TGFB1	ENSPPAP00000024694	ENSPPAP00000017066	Catenin beta 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.568
ENSPPAP00000023305	TRAF6	ENSPPAP00000023305	ENSPPAP00000040651	DJ-1_PfpI domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.487
EP300	CTNNB1	ENSPPAP00000019195	ENSPPAP00000024694	E1A binding protein p300.	Catenin beta 1.	0.998
EP300	GATA3	ENSPPAP00000019195	ENSPPAP00000007588	E1A binding protein p300.	GATA binding protein 3.	0.928
EP300	GTF2B	ENSPPAP00000019195	ENSPPAP00000034829	E1A binding protein p300.	General transcription factor IIB.	0.803
EP300	KLF4	ENSPPAP00000019195	ENSPPAP00000003618	E1A binding protein p300.	Kruppel like factor 4.	0.872
EP300	PARP1	ENSPPAP00000019195	ENSPPAP00000036168	E1A binding protein p300.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.800
EP300	PAX6	ENSPPAP00000019195	ENSPPAP00000042369	E1A binding protein p300.	Uncharacterized protein.	0.852
EP300	RB1	ENSPPAP00000019195	ENSPPAP00000000745	E1A binding protein p300.	RB transcriptional corepressor 1.	0.623
EP300	TGFB1	ENSPPAP00000019195	ENSPPAP00000017066	E1A binding protein p300.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.678
GATA3	EP300	ENSPPAP00000007588	ENSPPAP00000019195	GATA binding protein 3.	E1A binding protein p300.	0.928
GATA3	HAND2	ENSPPAP00000007588	ENSPPAP00000002765	GATA binding protein 3.	Uncharacterized protein.	0.581
GATA3	IFNG	ENSPPAP00000007588	ENSPPAP00000038608	GATA binding protein 3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.762